One-step synthesis of N-succinimidyl-4-[18F]Fluorobenzoate ([18F]SFB)

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

One-step synthesis of N-succinimidyl-4-[18F]Fluorobenzoate ([18F]SFB). / Petersen, Ida Nymann; Madsen, Jacob; Poulie, Christian Bernard Matthijs; Kjær, Andreas; Herth, Matthias Manfred.

In: Molecules, Vol. 24, No. 19, 3436, 22.09.2019.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Petersen, IN, Madsen, J, Poulie, CBM, Kjær, A & Herth, MM 2019, 'One-step synthesis of N-succinimidyl-4-[18F]Fluorobenzoate ([18F]SFB)', Molecules, vol. 24, no. 19, 3436. https://doi.org/10.3390/molecules24193436

APA

Petersen, I. N., Madsen, J., Poulie, C. B. M., Kjær, A., & Herth, M. M. (2019). One-step synthesis of N-succinimidyl-4-[18F]Fluorobenzoate ([18F]SFB). Molecules, 24(19), [3436]. https://doi.org/10.3390/molecules24193436

Vancouver

Petersen IN, Madsen J, Poulie CBM, Kjær A, Herth MM. One-step synthesis of N-succinimidyl-4-[18F]Fluorobenzoate ([18F]SFB). Molecules. 2019 Sep 22;24(19). 3436. https://doi.org/10.3390/molecules24193436

Author

Petersen, Ida Nymann ; Madsen, Jacob ; Poulie, Christian Bernard Matthijs ; Kjær, Andreas ; Herth, Matthias Manfred. / One-step synthesis of N-succinimidyl-4-[18F]Fluorobenzoate ([18F]SFB). In: Molecules. 2019 ; Vol. 24, No. 19.

Bibtex

@article{b0ae36abd33d4054bda3d893fb0f3104,
title = "One-step synthesis of N-succinimidyl-4-[18F]Fluorobenzoate ([18F]SFB)",
abstract = "Herein, we present a one-step labeling procedure of N-succinimidyl-4-[18F]-fluorobenzoate ([18F]SFB) starting from spirocyclic iodonium ylide precursors. Precursor syntheses succeeded via a simple one-pot, two-step synthesis sequence, in yields of approximately 25%. Subsequent 18F-nucleophilic aromatic labeling was performed, and radiochemical incorporations (RCCs) from 5-35% were observed. Purification could be carried out using HPLC and subsequent solid phase extraction. Radiochemical purity (RCP) of >95% was determined. The total synthesis time, including purification and formulation, was no longer than 60 min. In comparison to the established 3-step synthesis route of [18F]SFB, this one-step approach avoids formation of volatile radioactive side-products and simplifies automatization.",
keywords = "Fluorine-18, Iodonium ylides, N-succinimidyl-4-[F]fluorobenzoate, PET, [F]SFB",
author = "Petersen, {Ida Nymann} and Jacob Madsen and Poulie, {Christian Bernard Matthijs} and Andreas Kj{\ae}r and Herth, {Matthias Manfred}",
year = "2019",
month = sep,
day = "22",
doi = "10.3390/molecules24193436",
language = "English",
volume = "24",
journal = "Molecules (Print Archive Edition)",
issn = "1431-5157",
publisher = "M D P I AG",
number = "19",

}

RIS

TY - JOUR

T1 - One-step synthesis of N-succinimidyl-4-[18F]Fluorobenzoate ([18F]SFB)

AU - Petersen, Ida Nymann

AU - Madsen, Jacob

AU - Poulie, Christian Bernard Matthijs

AU - Kjær, Andreas

AU - Herth, Matthias Manfred

PY - 2019/9/22

Y1 - 2019/9/22

N2 - Herein, we present a one-step labeling procedure of N-succinimidyl-4-[18F]-fluorobenzoate ([18F]SFB) starting from spirocyclic iodonium ylide precursors. Precursor syntheses succeeded via a simple one-pot, two-step synthesis sequence, in yields of approximately 25%. Subsequent 18F-nucleophilic aromatic labeling was performed, and radiochemical incorporations (RCCs) from 5-35% were observed. Purification could be carried out using HPLC and subsequent solid phase extraction. Radiochemical purity (RCP) of >95% was determined. The total synthesis time, including purification and formulation, was no longer than 60 min. In comparison to the established 3-step synthesis route of [18F]SFB, this one-step approach avoids formation of volatile radioactive side-products and simplifies automatization.

AB - Herein, we present a one-step labeling procedure of N-succinimidyl-4-[18F]-fluorobenzoate ([18F]SFB) starting from spirocyclic iodonium ylide precursors. Precursor syntheses succeeded via a simple one-pot, two-step synthesis sequence, in yields of approximately 25%. Subsequent 18F-nucleophilic aromatic labeling was performed, and radiochemical incorporations (RCCs) from 5-35% were observed. Purification could be carried out using HPLC and subsequent solid phase extraction. Radiochemical purity (RCP) of >95% was determined. The total synthesis time, including purification and formulation, was no longer than 60 min. In comparison to the established 3-step synthesis route of [18F]SFB, this one-step approach avoids formation of volatile radioactive side-products and simplifies automatization.

KW - Fluorine-18

KW - Iodonium ylides

KW - N-succinimidyl-4-[F]fluorobenzoate

KW - PET

KW - [F]SFB

U2 - 10.3390/molecules24193436

DO - 10.3390/molecules24193436

M3 - Journal article

C2 - 31546683

AN - SCOPUS:85072572804

VL - 24

JO - Molecules (Print Archive Edition)

JF - Molecules (Print Archive Edition)

SN - 1431-5157

IS - 19

M1 - 3436

ER -

ID: 231210943