Oxidative stress in optic neuropathies

Research output: Contribution to journal › Review › Research › peer-review

Standard

Oxidative stress in optic neuropathies. / Sanz-Morello, Berta; Ahmadi, Hamid; Vohra, Rupali; Saruhanian, Sarkis; Freude, Kristine Karla; Hamann, Steffen; Kolko, Miriam.

In: Antioxidants, Vol. 10, No. 10, 1538, 2021.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Sanz-Morello, B, Ahmadi, H, Vohra, R, Saruhanian, S, Freude, KK, Hamann, S & Kolko, M 2021, 'Oxidative stress in optic neuropathies', Antioxidants, vol. 10, no. 10, 1538. https://doi.org/10.3390/antiox10101538

APA

Sanz-Morello, B., Ahmadi, H., Vohra, R., Saruhanian, S., Freude, K. K., Hamann, S., & Kolko, M. (2021). Oxidative stress in optic neuropathies. Antioxidants, 10(10), [1538]. https://doi.org/10.3390/antiox10101538

Vancouver

Sanz-Morello B, Ahmadi H, Vohra R, Saruhanian S, Freude KK, Hamann S et al. Oxidative stress in optic neuropathies. Antioxidants. 2021;10(10). 1538. https://doi.org/10.3390/antiox10101538

Author

Sanz-Morello, Berta ; Ahmadi, Hamid ; Vohra, Rupali ; Saruhanian, Sarkis ; Freude, Kristine Karla ; Hamann, Steffen ; Kolko, Miriam. / Oxidative stress in optic neuropathies. In: Antioxidants. 2021 ; Vol. 10, No. 10.

Bibtex

@article{7d7a8a8a7cca4d35aa7db27a5b73b190,
title = "Oxidative stress in optic neuropathies",
abstract = "Increasing evidence indicates that changes in the redox system may contribute to the pathogenesis of multiple optic neuropathies. Optic neuropathies are characterized by the neurodegeneration of the inner-most retinal neurons, the retinal ganglion cells (RGCs), and their axons, which form the optic nerve. Often, optic neuropathies are asymptomatic until advanced stages, when visual impairment or blindness is unavoidable despite existing treatments. In this review, we describe systemic and, whenever possible, ocular redox dysregulations observed in patients with glaucoma, ischemic optic neuropathy, optic neuritis, hereditary optic neuropathies (i.e., Leber{\textquoteright}s hereditary optic neuropathy and autosomal dominant optic atrophy), nutritional and toxic optic neuropathies, and optic disc drusen. We discuss aspects related to anti/oxidative stress biomarkers that need further investigation and features related to study design that should be optimized to generate more valuable and comparable results. Understanding the role of oxidative stress in optic neuropathies can serve to develop therapeutic strategies directed at the redox system to arrest the neurodegenerative processes in the retina and RGCs and ultimately prevent vision loss.",
keywords = "Glaucoma, Mitochondria, Optic disc drusen, Optic neuropathy, Oxidative stress, Redox dysregulations, Retinal ganglion cell",
author = "Berta Sanz-Morello and Hamid Ahmadi and Rupali Vohra and Sarkis Saruhanian and Freude, {Kristine Karla} and Steffen Hamann and Miriam Kolko",
note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2021",
doi = "10.3390/antiox10101538",
language = "English",
volume = "10",
journal = "Antioxidants",
issn = "2076-3921",
publisher = "M D P I AG",
number = "10",

}

RIS

TY - JOUR

T1 - Oxidative stress in optic neuropathies

AU - Sanz-Morello, Berta

AU - Ahmadi, Hamid

AU - Vohra, Rupali

AU - Saruhanian, Sarkis

AU - Freude, Kristine Karla

AU - Hamann, Steffen

AU - Kolko, Miriam

N1 - Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021

Y1 - 2021

N2 - Increasing evidence indicates that changes in the redox system may contribute to the pathogenesis of multiple optic neuropathies. Optic neuropathies are characterized by the neurodegeneration of the inner-most retinal neurons, the retinal ganglion cells (RGCs), and their axons, which form the optic nerve. Often, optic neuropathies are asymptomatic until advanced stages, when visual impairment or blindness is unavoidable despite existing treatments. In this review, we describe systemic and, whenever possible, ocular redox dysregulations observed in patients with glaucoma, ischemic optic neuropathy, optic neuritis, hereditary optic neuropathies (i.e., Leber’s hereditary optic neuropathy and autosomal dominant optic atrophy), nutritional and toxic optic neuropathies, and optic disc drusen. We discuss aspects related to anti/oxidative stress biomarkers that need further investigation and features related to study design that should be optimized to generate more valuable and comparable results. Understanding the role of oxidative stress in optic neuropathies can serve to develop therapeutic strategies directed at the redox system to arrest the neurodegenerative processes in the retina and RGCs and ultimately prevent vision loss.

AB - Increasing evidence indicates that changes in the redox system may contribute to the pathogenesis of multiple optic neuropathies. Optic neuropathies are characterized by the neurodegeneration of the inner-most retinal neurons, the retinal ganglion cells (RGCs), and their axons, which form the optic nerve. Often, optic neuropathies are asymptomatic until advanced stages, when visual impairment or blindness is unavoidable despite existing treatments. In this review, we describe systemic and, whenever possible, ocular redox dysregulations observed in patients with glaucoma, ischemic optic neuropathy, optic neuritis, hereditary optic neuropathies (i.e., Leber’s hereditary optic neuropathy and autosomal dominant optic atrophy), nutritional and toxic optic neuropathies, and optic disc drusen. We discuss aspects related to anti/oxidative stress biomarkers that need further investigation and features related to study design that should be optimized to generate more valuable and comparable results. Understanding the role of oxidative stress in optic neuropathies can serve to develop therapeutic strategies directed at the redox system to arrest the neurodegenerative processes in the retina and RGCs and ultimately prevent vision loss.

KW - Glaucoma

KW - Mitochondria

KW - Optic disc drusen

KW - Optic neuropathy

KW - Oxidative stress

KW - Redox dysregulations

KW - Retinal ganglion cell

U2 - 10.3390/antiox10101538

DO - 10.3390/antiox10101538

M3 - Review

C2 - 34679672

AN - SCOPUS:85115884920

VL - 10

JO - Antioxidants

JF - Antioxidants

SN - 2076-3921

IS - 10

M1 - 1538

ER -

ID: 281156683