Pepticinnamins N, O, and P, Nonribosomal Peptides from the Soil-Derived Streptomyces mirabilis P8-A2

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Pepticinnamins N, O, and P, Nonribosomal Peptides from the Soil-Derived Streptomyces mirabilis P8-A2. / Mohamed, Manar Magdy Mahmoud; Abboud, Maria Mahmoud; Maleckis, Matiss; Souza, Luciano D.O.; Moreira, José M.A.; Gotfredsen, Charlotte H.; Weber, Tilmann; Ding, Ling.

In: Journal of Natural Products, Vol. 87, No. 4, 2024, p. 1075–1083.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Mohamed, MMM, Abboud, MM, Maleckis, M, Souza, LDO, Moreira, JMA, Gotfredsen, CH, Weber, T & Ding, L 2024, 'Pepticinnamins N, O, and P, Nonribosomal Peptides from the Soil-Derived Streptomyces mirabilis P8-A2', Journal of Natural Products, vol. 87, no. 4, pp. 1075–1083. https://doi.org/10.1021/acs.jnatprod.4c00029

APA

Mohamed, M. M. M., Abboud, M. M., Maleckis, M., Souza, L. D. O., Moreira, J. M. A., Gotfredsen, C. H., Weber, T., & Ding, L. (2024). Pepticinnamins N, O, and P, Nonribosomal Peptides from the Soil-Derived Streptomyces mirabilis P8-A2. Journal of Natural Products, 87(4), 1075–1083. https://doi.org/10.1021/acs.jnatprod.4c00029

Vancouver

Mohamed MMM, Abboud MM, Maleckis M, Souza LDO, Moreira JMA, Gotfredsen CH et al. Pepticinnamins N, O, and P, Nonribosomal Peptides from the Soil-Derived Streptomyces mirabilis P8-A2. Journal of Natural Products. 2024;87(4):1075–1083. https://doi.org/10.1021/acs.jnatprod.4c00029

Author

Mohamed, Manar Magdy Mahmoud ; Abboud, Maria Mahmoud ; Maleckis, Matiss ; Souza, Luciano D.O. ; Moreira, José M.A. ; Gotfredsen, Charlotte H. ; Weber, Tilmann ; Ding, Ling. / Pepticinnamins N, O, and P, Nonribosomal Peptides from the Soil-Derived Streptomyces mirabilis P8-A2. In: Journal of Natural Products. 2024 ; Vol. 87, No. 4. pp. 1075–1083.

Bibtex

@article{ed7068d406884fe4a2f01447f86974f5,
title = "Pepticinnamins N, O, and P, Nonribosomal Peptides from the Soil-Derived Streptomyces mirabilis P8-A2",
abstract = "Cinnamoyl moiety containing nonribosomal peptides represented by pepticinnamin E are a growing family of natural products isolated from different Streptomyces species and possess diverse bioactivities. The soil bacterium Streptomyces mirabilis P8-A2 harbors a cryptic pepticinnamin biosynthetic gene cluster, producing azodyrecins as major products. Inactivation of the azodyrecin biosynthetic gene cluster by CRISPR-BEST base editing led to the activation and production of pepticinnamin E (1) and its analogues, pepticinnamins N, O, and P (2-4), the structures of which were determined by detailed NMR spectroscopy, HRMS data, and Marfey{\textquoteright}s reactions. These new compounds did not show a growth inhibitory effect against the LNCaP and C4-2B prostate cancer lines, respectively.",
author = "Mohamed, {Manar Magdy Mahmoud} and Abboud, {Maria Mahmoud} and Matiss Maleckis and Souza, {Luciano D.O.} and Moreira, {Jos{\'e} M.A.} and Gotfredsen, {Charlotte H.} and Tilmann Weber and Ling Ding",
note = "Publisher Copyright: {\textcopyright} 2024 American Chemical Society and American Society of Pharmacognosy.",
year = "2024",
doi = "10.1021/acs.jnatprod.4c00029",
language = "English",
volume = "87",
pages = "1075–1083",
journal = "Journal of Natural Products",
issn = "0163-3864",
publisher = "American Chemical Society",
number = "4",

}

RIS

TY - JOUR

T1 - Pepticinnamins N, O, and P, Nonribosomal Peptides from the Soil-Derived Streptomyces mirabilis P8-A2

AU - Mohamed, Manar Magdy Mahmoud

AU - Abboud, Maria Mahmoud

AU - Maleckis, Matiss

AU - Souza, Luciano D.O.

AU - Moreira, José M.A.

AU - Gotfredsen, Charlotte H.

AU - Weber, Tilmann

AU - Ding, Ling

N1 - Publisher Copyright: © 2024 American Chemical Society and American Society of Pharmacognosy.

PY - 2024

Y1 - 2024

N2 - Cinnamoyl moiety containing nonribosomal peptides represented by pepticinnamin E are a growing family of natural products isolated from different Streptomyces species and possess diverse bioactivities. The soil bacterium Streptomyces mirabilis P8-A2 harbors a cryptic pepticinnamin biosynthetic gene cluster, producing azodyrecins as major products. Inactivation of the azodyrecin biosynthetic gene cluster by CRISPR-BEST base editing led to the activation and production of pepticinnamin E (1) and its analogues, pepticinnamins N, O, and P (2-4), the structures of which were determined by detailed NMR spectroscopy, HRMS data, and Marfey’s reactions. These new compounds did not show a growth inhibitory effect against the LNCaP and C4-2B prostate cancer lines, respectively.

AB - Cinnamoyl moiety containing nonribosomal peptides represented by pepticinnamin E are a growing family of natural products isolated from different Streptomyces species and possess diverse bioactivities. The soil bacterium Streptomyces mirabilis P8-A2 harbors a cryptic pepticinnamin biosynthetic gene cluster, producing azodyrecins as major products. Inactivation of the azodyrecin biosynthetic gene cluster by CRISPR-BEST base editing led to the activation and production of pepticinnamin E (1) and its analogues, pepticinnamins N, O, and P (2-4), the structures of which were determined by detailed NMR spectroscopy, HRMS data, and Marfey’s reactions. These new compounds did not show a growth inhibitory effect against the LNCaP and C4-2B prostate cancer lines, respectively.

U2 - 10.1021/acs.jnatprod.4c00029

DO - 10.1021/acs.jnatprod.4c00029

M3 - Journal article

C2 - 38591246

AN - SCOPUS:85190113337

VL - 87

SP - 1075

EP - 1083

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 4

ER -

ID: 389088311