Pharmacological Tool Compounds for the Free Fatty Acid Receptor 4 (FFA4/GPR120)

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Standard

Pharmacological Tool Compounds for the Free Fatty Acid Receptor 4 (FFA4/GPR120). / Hansen, Steffen V F; Ulven, Trond.

Free Fatty Acid Receptors. Springer Science+Business Media, 2017. p. 33-56.

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Harvard

Hansen, SVF & Ulven, T 2017, Pharmacological Tool Compounds for the Free Fatty Acid Receptor 4 (FFA4/GPR120). in Free Fatty Acid Receptors. Springer Science+Business Media, pp. 33-56. https://doi.org/10.1007/164_2016_60

APA

Hansen, S. V. F., & Ulven, T. (2017). Pharmacological Tool Compounds for the Free Fatty Acid Receptor 4 (FFA4/GPR120). In Free Fatty Acid Receptors (pp. 33-56). Springer Science+Business Media. https://doi.org/10.1007/164_2016_60

Vancouver

Hansen SVF, Ulven T. Pharmacological Tool Compounds for the Free Fatty Acid Receptor 4 (FFA4/GPR120). In Free Fatty Acid Receptors. Springer Science+Business Media. 2017. p. 33-56 https://doi.org/10.1007/164_2016_60

Author

Hansen, Steffen V F ; Ulven, Trond. / Pharmacological Tool Compounds for the Free Fatty Acid Receptor 4 (FFA4/GPR120). Free Fatty Acid Receptors. Springer Science+Business Media, 2017. pp. 33-56

Bibtex

@inbook{0830844806cd4975a9ea2339b382434d,
title = "Pharmacological Tool Compounds for the Free Fatty Acid Receptor 4 (FFA4/GPR120)",
abstract = "The free fatty acid receptor 4 (FFA4), also known as GPR120, is a G protein-coupled receptor that is activated by long-chain fatty acids and that has been associated with regulation of appetite, release of insulin controlling hormones, insulin sensitization, anti-inflammatory and potentially anti-obesity activity, and is progressively appearing as an attractive potential target for the treatment of metabolic dysfunctions such as obesity, type 2 diabetes and inflammatory disorders. Ongoing investigations of the pharmacological functions of FFA4 and validation of its potential as a therapeutic target depend critically on the appropriateness and quality of the available pharmacological probes or tool compounds. After a brief summary of the pharmacological functions of FFA4 and some general considerations on desirable properties for these pharmacological tool compounds, the individual compounds that have been or are currently being used as tools for probing the function of FFA4 in various in vitro and in vivo settings will be discussed and evaluated.",
author = "Hansen, {Steffen V F} and Trond Ulven",
year = "2017",
doi = "10.1007/164_2016_60",
language = "English",
isbn = "978-3-319-50692-0",
pages = "33--56",
booktitle = "Free Fatty Acid Receptors",
publisher = "Springer Science+Business Media",
address = "Singapore",

}

RIS

TY - CHAP

T1 - Pharmacological Tool Compounds for the Free Fatty Acid Receptor 4 (FFA4/GPR120)

AU - Hansen, Steffen V F

AU - Ulven, Trond

PY - 2017

Y1 - 2017

N2 - The free fatty acid receptor 4 (FFA4), also known as GPR120, is a G protein-coupled receptor that is activated by long-chain fatty acids and that has been associated with regulation of appetite, release of insulin controlling hormones, insulin sensitization, anti-inflammatory and potentially anti-obesity activity, and is progressively appearing as an attractive potential target for the treatment of metabolic dysfunctions such as obesity, type 2 diabetes and inflammatory disorders. Ongoing investigations of the pharmacological functions of FFA4 and validation of its potential as a therapeutic target depend critically on the appropriateness and quality of the available pharmacological probes or tool compounds. After a brief summary of the pharmacological functions of FFA4 and some general considerations on desirable properties for these pharmacological tool compounds, the individual compounds that have been or are currently being used as tools for probing the function of FFA4 in various in vitro and in vivo settings will be discussed and evaluated.

AB - The free fatty acid receptor 4 (FFA4), also known as GPR120, is a G protein-coupled receptor that is activated by long-chain fatty acids and that has been associated with regulation of appetite, release of insulin controlling hormones, insulin sensitization, anti-inflammatory and potentially anti-obesity activity, and is progressively appearing as an attractive potential target for the treatment of metabolic dysfunctions such as obesity, type 2 diabetes and inflammatory disorders. Ongoing investigations of the pharmacological functions of FFA4 and validation of its potential as a therapeutic target depend critically on the appropriateness and quality of the available pharmacological probes or tool compounds. After a brief summary of the pharmacological functions of FFA4 and some general considerations on desirable properties for these pharmacological tool compounds, the individual compounds that have been or are currently being used as tools for probing the function of FFA4 in various in vitro and in vivo settings will be discussed and evaluated.

U2 - 10.1007/164_2016_60

DO - 10.1007/164_2016_60

M3 - Book chapter

C2 - 27807695

SN - 978-3-319-50692-0

SP - 33

EP - 56

BT - Free Fatty Acid Receptors

PB - Springer Science+Business Media

ER -

ID: 189161746