Plasma levels of the MMP-9:TIMP-1 complex as prognostic biomarker in breast cancer: a retrospective study
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Plasma levels of the MMP-9:TIMP-1 complex as prognostic biomarker in breast cancer : a retrospective study. / Thorsen, Stine Buch; Christensen, Sarah Louise T; Würtz, Sidse Ørnbjerg; Lundberg, Martin; Nielsen, Birgitte Egedie Sander; Jensen, Lena Vinther; Knowles, Mick; Gee, Nick; Fredriksson, Simon; Møller, Susanne; Brünner, Nils; Rasmussen, Anne-Sofie Schrohl; Stenvang, Jan.
In: B M C Cancer, Vol. 13, 598, 2013.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Plasma levels of the MMP-9:TIMP-1 complex as prognostic biomarker in breast cancer
T2 - a retrospective study
AU - Thorsen, Stine Buch
AU - Christensen, Sarah Louise T
AU - Würtz, Sidse Ørnbjerg
AU - Lundberg, Martin
AU - Nielsen, Birgitte Egedie Sander
AU - Jensen, Lena Vinther
AU - Knowles, Mick
AU - Gee, Nick
AU - Fredriksson, Simon
AU - Møller, Susanne
AU - Brünner, Nils
AU - Rasmussen, Anne-Sofie Schrohl
AU - Stenvang, Jan
PY - 2013
Y1 - 2013
N2 - Worldwide more than one million women are annually diagnosed with breast cancer. A considerable fraction of these women receive systemic adjuvant therapy; however, some are cured by primary surgery and radiotherapy alone. Prognostic biomarkers guide stratification of patients into different risk groups and hence improve management of breast cancer patients. Plasma levels of Matrix Metalloproteinase-9 (MMP-9) and its natural inhibitor Tissue inhibitor of metalloproteinase-1 (TIMP-1) have previously been associated with poor patient outcome and resistance to certain forms of chemotherapy. To pursue additional prognostic information from MMP-9 and TIMP-1, the level of the MMP-9 and TIMP-1 complex (MMP-9:TIMP-1) was investigated in plasma from breast cancer patients.
AB - Worldwide more than one million women are annually diagnosed with breast cancer. A considerable fraction of these women receive systemic adjuvant therapy; however, some are cured by primary surgery and radiotherapy alone. Prognostic biomarkers guide stratification of patients into different risk groups and hence improve management of breast cancer patients. Plasma levels of Matrix Metalloproteinase-9 (MMP-9) and its natural inhibitor Tissue inhibitor of metalloproteinase-1 (TIMP-1) have previously been associated with poor patient outcome and resistance to certain forms of chemotherapy. To pursue additional prognostic information from MMP-9 and TIMP-1, the level of the MMP-9 and TIMP-1 complex (MMP-9:TIMP-1) was investigated in plasma from breast cancer patients.
U2 - 10.1186/1471-2407-13-598
DO - 10.1186/1471-2407-13-598
M3 - Journal article
C2 - 24330623
VL - 13
JO - B M C Cancer
JF - B M C Cancer
SN - 1471-2407
M1 - 598
ER -
ID: 98037944