Potential of Myrtus communis Linn. as a bifunctional food: Dual high-resolution PTP1B and α-glucosidase inhibition profiling combined with HPLC-HRMS and NMR for identification of antidiabetic triterpenoids and phloroglucinol derivatives

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Potential of Myrtus communis Linn. as a bifunctional food: Dual high-resolution PTP1B and α-glucosidase inhibition profiling combined with HPLC-HRMS and NMR for identification of antidiabetic triterpenoids and phloroglucinol derivatives. / Liang, Chao; Stærk, Dan; Kongstad, Kenneth Thermann.

In: Journal of Functional Foods, Vol. 64, 103623, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Liang, C, Stærk, D & Kongstad, KT 2020, 'Potential of Myrtus communis Linn. as a bifunctional food: Dual high-resolution PTP1B and α-glucosidase inhibition profiling combined with HPLC-HRMS and NMR for identification of antidiabetic triterpenoids and phloroglucinol derivatives', Journal of Functional Foods, vol. 64, 103623. https://doi.org/10.1016/j.jff.2019.103623

APA

Liang, C., Stærk, D., & Kongstad, K. T. (2020). Potential of Myrtus communis Linn. as a bifunctional food: Dual high-resolution PTP1B and α-glucosidase inhibition profiling combined with HPLC-HRMS and NMR for identification of antidiabetic triterpenoids and phloroglucinol derivatives. Journal of Functional Foods, 64, [103623]. https://doi.org/10.1016/j.jff.2019.103623

Vancouver

Liang C, Stærk D, Kongstad KT. Potential of Myrtus communis Linn. as a bifunctional food: Dual high-resolution PTP1B and α-glucosidase inhibition profiling combined with HPLC-HRMS and NMR for identification of antidiabetic triterpenoids and phloroglucinol derivatives. Journal of Functional Foods. 2020;64. 103623. https://doi.org/10.1016/j.jff.2019.103623

Author

Liang, Chao ; Stærk, Dan ; Kongstad, Kenneth Thermann. / Potential of Myrtus communis Linn. as a bifunctional food: Dual high-resolution PTP1B and α-glucosidase inhibition profiling combined with HPLC-HRMS and NMR for identification of antidiabetic triterpenoids and phloroglucinol derivatives. In: Journal of Functional Foods. 2020 ; Vol. 64.

Bibtex

@article{611879a1fda84a77b36d2ce60ee2e24d,
title = "Potential of Myrtus communis Linn. as a bifunctional food: Dual high-resolution PTP1B and α-glucosidase inhibition profiling combined with HPLC-HRMS and NMR for identification of antidiabetic triterpenoids and phloroglucinol derivatives",
abstract = "Myrtus communis Linn., an aromatic shrub widely distributed in Mediterranean littoral, is traditionally used as a culinary herb and for manufacturing of the local Sardinian liquor, Mirto. In this study, the potential for developing M. communis into a functional food to treat type-2-diabetes (T2D) was investigated. Antidiabetic constituents in crude defatted chloroform extract of M. communis was pinpointed by dual high-resolution PTP1B and α-glucosidase inhibition profiling. Subsequent analytical-scale HPLC separation led to isolation and identification of 14 triterpenoids and three phloroglucinol derivatives associated with PTP1B and/or α-glucosidase inhibitory activity with IC50 values in the range of 8.9-69.4 μM and 34.3-88.5 μM, respectively. We also report three previously undescribed phloroglucinol derivatives. This is the first report of PTP1B inhibitors in M. communis, and the identification of both PTP1B and α-glucosidase inhibitors, demonstrates the potential of M. communis as a bifunctional food for management of TD2.",
author = "Chao Liang and Dan St{\ae}rk and Kongstad, {Kenneth Thermann}",
year = "2020",
doi = "10.1016/j.jff.2019.103623",
language = "English",
volume = "64",
journal = "Journal of Functional Foods",
issn = "1756-4646",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Potential of Myrtus communis Linn. as a bifunctional food: Dual high-resolution PTP1B and α-glucosidase inhibition profiling combined with HPLC-HRMS and NMR for identification of antidiabetic triterpenoids and phloroglucinol derivatives

AU - Liang, Chao

AU - Stærk, Dan

AU - Kongstad, Kenneth Thermann

PY - 2020

Y1 - 2020

N2 - Myrtus communis Linn., an aromatic shrub widely distributed in Mediterranean littoral, is traditionally used as a culinary herb and for manufacturing of the local Sardinian liquor, Mirto. In this study, the potential for developing M. communis into a functional food to treat type-2-diabetes (T2D) was investigated. Antidiabetic constituents in crude defatted chloroform extract of M. communis was pinpointed by dual high-resolution PTP1B and α-glucosidase inhibition profiling. Subsequent analytical-scale HPLC separation led to isolation and identification of 14 triterpenoids and three phloroglucinol derivatives associated with PTP1B and/or α-glucosidase inhibitory activity with IC50 values in the range of 8.9-69.4 μM and 34.3-88.5 μM, respectively. We also report three previously undescribed phloroglucinol derivatives. This is the first report of PTP1B inhibitors in M. communis, and the identification of both PTP1B and α-glucosidase inhibitors, demonstrates the potential of M. communis as a bifunctional food for management of TD2.

AB - Myrtus communis Linn., an aromatic shrub widely distributed in Mediterranean littoral, is traditionally used as a culinary herb and for manufacturing of the local Sardinian liquor, Mirto. In this study, the potential for developing M. communis into a functional food to treat type-2-diabetes (T2D) was investigated. Antidiabetic constituents in crude defatted chloroform extract of M. communis was pinpointed by dual high-resolution PTP1B and α-glucosidase inhibition profiling. Subsequent analytical-scale HPLC separation led to isolation and identification of 14 triterpenoids and three phloroglucinol derivatives associated with PTP1B and/or α-glucosidase inhibitory activity with IC50 values in the range of 8.9-69.4 μM and 34.3-88.5 μM, respectively. We also report three previously undescribed phloroglucinol derivatives. This is the first report of PTP1B inhibitors in M. communis, and the identification of both PTP1B and α-glucosidase inhibitors, demonstrates the potential of M. communis as a bifunctional food for management of TD2.

U2 - 10.1016/j.jff.2019.103623

DO - 10.1016/j.jff.2019.103623

M3 - Journal article

VL - 64

JO - Journal of Functional Foods

JF - Journal of Functional Foods

SN - 1756-4646

M1 - 103623

ER -

ID: 228301419