Prenatal Stress and Acute Stress Later in Life Impacts the Responses in Tests for Depressive-Like Behavior in a Sex-Specific Manner

Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

Standard

Prenatal Stress and Acute Stress Later in Life Impacts the Responses in Tests for Depressive-Like Behavior in a Sex-Specific Manner. / Sickmann, Helle Mark; Skoven, Christian; Arentzen, Tina S.; Plath, Niels; Bastlund, Jesper F.; Dyrby, Tim B.; Kohlmeier, Kristi Anne; Zhang, Hui; Kristensen, Morten Pilgaard.

2015. Abstract from Annual Meeting of the International Behavioral Neuroscience Society, Victoria, British Columbia, Canada.

Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

Harvard

Sickmann, HM, Skoven, C, Arentzen, TS, Plath, N, Bastlund, JF, Dyrby, TB, Kohlmeier, KA, Zhang, H & Kristensen, MP 2015, 'Prenatal Stress and Acute Stress Later in Life Impacts the Responses in Tests for Depressive-Like Behavior in a Sex-Specific Manner', Annual Meeting of the International Behavioral Neuroscience Society, Victoria, British Columbia, Canada, 02/06/2015 - 07/06/2015.

APA

Sickmann, H. M., Skoven, C., Arentzen, T. S., Plath, N., Bastlund, J. F., Dyrby, T. B., Kohlmeier, K. A., Zhang, H., & Kristensen, M. P. (2015). Prenatal Stress and Acute Stress Later in Life Impacts the Responses in Tests for Depressive-Like Behavior in a Sex-Specific Manner. Abstract from Annual Meeting of the International Behavioral Neuroscience Society, Victoria, British Columbia, Canada.

Vancouver

Sickmann HM, Skoven C, Arentzen TS, Plath N, Bastlund JF, Dyrby TB et al. Prenatal Stress and Acute Stress Later in Life Impacts the Responses in Tests for Depressive-Like Behavior in a Sex-Specific Manner. 2015. Abstract from Annual Meeting of the International Behavioral Neuroscience Society, Victoria, British Columbia, Canada.

Author

Sickmann, Helle Mark ; Skoven, Christian ; Arentzen, Tina S. ; Plath, Niels ; Bastlund, Jesper F. ; Dyrby, Tim B. ; Kohlmeier, Kristi Anne ; Zhang, Hui ; Kristensen, Morten Pilgaard. / Prenatal Stress and Acute Stress Later in Life Impacts the Responses in Tests for Depressive-Like Behavior in a Sex-Specific Manner. Abstract from Annual Meeting of the International Behavioral Neuroscience Society, Victoria, British Columbia, Canada.2 p.

Bibtex

@conference{cc3faf3060dd4e669e8ea31576ce84cb,
title = "Prenatal Stress and Acute Stress Later in Life Impacts the Responses in Tests for Depressive-Like Behavior in a Sex-Specific Manner",
abstract = "Prenatal maternal stressincreases the predisposition for affective disorders. Furthermore, women appear twice as likely asmen to develop stress- and depression-related disorders. Comparable behavioral changescharacteristic of clinical depression are found in rat offspring following prenatal stress (PS). Theseinclude increased helplessness, altered anxiety indicators and sleep modifications. Our purpose wasto further investigate behavioral depression indices following PS as well as CNS structural changesincluding sex specificity of these variables. Pregnant Sprague-Dawley rats were exposed to repeatedvariable stress during days 13-21 of gestation. The PS paradigm consisted of two short-termstressors during the day (e.g. restraint and forced swimming) and a long-term stressor overnight (e.g.66fasting or lights on). We examined the rats at a young adult age for changes in locomotor activity,depressive- and anxiety-like behavior as well as sleep architecture. Some animals were analyzed forCNS microstructural changes based on diffusion MRI. Subsets of PS and control rats were exposedto an acute stressor prior to the behavioral tests. Rearing/climbing activity in a familiar environment(housing cage) increased at the end of the light and beginning of the dark phases in PS offspringcompared to controls. PS per se did not appear to change anxiety-like behavior in either sex.However, exposure to an acute stressor increased exploratory behavior in control animals and,interestingly, PS blunted this effect. Relative and absolute numbers of rapid eye movement sleepbouts were higher in PS offspring. Moreover, exposure to an acute stressor induced a REM reboundeffect in control animals but this compensatory mechanism was blunted in PS animals. Finally,depression-like behavioral changes assessed in the forced swim test was selectively induced in PSfemales. The central mechanisms mediating these differences may contribute to sex-specificsensitivity to stressors and depression propensity in humans. ",
author = "Sickmann, {Helle Mark} and Christian Skoven and Arentzen, {Tina S.} and Niels Plath and Bastlund, {Jesper F.} and Dyrby, {Tim B.} and Kohlmeier, {Kristi Anne} and Hui Zhang and Kristensen, {Morten Pilgaard}",
year = "2015",
language = "English",
note = "Annual Meeting of the International Behavioral Neuroscience Society, IBNS 24th Annual Meeting ; Conference date: 02-06-2015 Through 07-06-2015",

}

RIS

TY - ABST

T1 - Prenatal Stress and Acute Stress Later in Life Impacts the Responses in Tests for Depressive-Like Behavior in a Sex-Specific Manner

AU - Sickmann, Helle Mark

AU - Skoven, Christian

AU - Arentzen, Tina S.

AU - Plath, Niels

AU - Bastlund, Jesper F.

AU - Dyrby, Tim B.

AU - Kohlmeier, Kristi Anne

AU - Zhang, Hui

AU - Kristensen, Morten Pilgaard

N1 - Conference code: 24

PY - 2015

Y1 - 2015

N2 - Prenatal maternal stressincreases the predisposition for affective disorders. Furthermore, women appear twice as likely asmen to develop stress- and depression-related disorders. Comparable behavioral changescharacteristic of clinical depression are found in rat offspring following prenatal stress (PS). Theseinclude increased helplessness, altered anxiety indicators and sleep modifications. Our purpose wasto further investigate behavioral depression indices following PS as well as CNS structural changesincluding sex specificity of these variables. Pregnant Sprague-Dawley rats were exposed to repeatedvariable stress during days 13-21 of gestation. The PS paradigm consisted of two short-termstressors during the day (e.g. restraint and forced swimming) and a long-term stressor overnight (e.g.66fasting or lights on). We examined the rats at a young adult age for changes in locomotor activity,depressive- and anxiety-like behavior as well as sleep architecture. Some animals were analyzed forCNS microstructural changes based on diffusion MRI. Subsets of PS and control rats were exposedto an acute stressor prior to the behavioral tests. Rearing/climbing activity in a familiar environment(housing cage) increased at the end of the light and beginning of the dark phases in PS offspringcompared to controls. PS per se did not appear to change anxiety-like behavior in either sex.However, exposure to an acute stressor increased exploratory behavior in control animals and,interestingly, PS blunted this effect. Relative and absolute numbers of rapid eye movement sleepbouts were higher in PS offspring. Moreover, exposure to an acute stressor induced a REM reboundeffect in control animals but this compensatory mechanism was blunted in PS animals. Finally,depression-like behavioral changes assessed in the forced swim test was selectively induced in PSfemales. The central mechanisms mediating these differences may contribute to sex-specificsensitivity to stressors and depression propensity in humans.

AB - Prenatal maternal stressincreases the predisposition for affective disorders. Furthermore, women appear twice as likely asmen to develop stress- and depression-related disorders. Comparable behavioral changescharacteristic of clinical depression are found in rat offspring following prenatal stress (PS). Theseinclude increased helplessness, altered anxiety indicators and sleep modifications. Our purpose wasto further investigate behavioral depression indices following PS as well as CNS structural changesincluding sex specificity of these variables. Pregnant Sprague-Dawley rats were exposed to repeatedvariable stress during days 13-21 of gestation. The PS paradigm consisted of two short-termstressors during the day (e.g. restraint and forced swimming) and a long-term stressor overnight (e.g.66fasting or lights on). We examined the rats at a young adult age for changes in locomotor activity,depressive- and anxiety-like behavior as well as sleep architecture. Some animals were analyzed forCNS microstructural changes based on diffusion MRI. Subsets of PS and control rats were exposedto an acute stressor prior to the behavioral tests. Rearing/climbing activity in a familiar environment(housing cage) increased at the end of the light and beginning of the dark phases in PS offspringcompared to controls. PS per se did not appear to change anxiety-like behavior in either sex.However, exposure to an acute stressor increased exploratory behavior in control animals and,interestingly, PS blunted this effect. Relative and absolute numbers of rapid eye movement sleepbouts were higher in PS offspring. Moreover, exposure to an acute stressor induced a REM reboundeffect in control animals but this compensatory mechanism was blunted in PS animals. Finally,depression-like behavioral changes assessed in the forced swim test was selectively induced in PSfemales. The central mechanisms mediating these differences may contribute to sex-specificsensitivity to stressors and depression propensity in humans.

UR - http://www.ibnsconnect.org/assets/docs/ibnsprogram2015.pdf

M3 - Conference abstract for conference

T2 - Annual Meeting of the International Behavioral Neuroscience Society

Y2 - 2 June 2015 through 7 June 2015

ER -

ID: 131453184