Radiosynthesis and in vivo evaluation of novel radioligands for PET imaging of cerebral 5-HT7 receptors

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Standard

Radiosynthesis and in vivo evaluation of novel radioligands for PET imaging of cerebral 5-HT7 receptors. / Hansen, Hanne D; Herth, Matthias M; Ettrup, Anders; Andersen, Valdemar L; Lehel, Szabolcs; Dyssegaard, Agnete; Kristensen, Jesper Langgaard; Knudsen, Gitte M.

In: Journal of Nuclear Medicine, Vol. 55, No. 4, 24.02.2014, p. 640-646.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hansen, HD, Herth, MM, Ettrup, A, Andersen, VL, Lehel, S, Dyssegaard, A, Kristensen, JL & Knudsen, GM 2014, 'Radiosynthesis and in vivo evaluation of novel radioligands for PET imaging of cerebral 5-HT7 receptors', Journal of Nuclear Medicine, vol. 55, no. 4, pp. 640-646. https://doi.org/10.2967/jnumed.113.128983

APA

Hansen, H. D., Herth, M. M., Ettrup, A., Andersen, V. L., Lehel, S., Dyssegaard, A., Kristensen, J. L., & Knudsen, G. M. (2014). Radiosynthesis and in vivo evaluation of novel radioligands for PET imaging of cerebral 5-HT7 receptors. Journal of Nuclear Medicine, 55(4), 640-646. https://doi.org/10.2967/jnumed.113.128983

Vancouver

Hansen HD, Herth MM, Ettrup A, Andersen VL, Lehel S, Dyssegaard A et al. Radiosynthesis and in vivo evaluation of novel radioligands for PET imaging of cerebral 5-HT7 receptors. Journal of Nuclear Medicine. 2014 Feb 24;55(4):640-646. https://doi.org/10.2967/jnumed.113.128983

Author

Hansen, Hanne D ; Herth, Matthias M ; Ettrup, Anders ; Andersen, Valdemar L ; Lehel, Szabolcs ; Dyssegaard, Agnete ; Kristensen, Jesper Langgaard ; Knudsen, Gitte M. / Radiosynthesis and in vivo evaluation of novel radioligands for PET imaging of cerebral 5-HT7 receptors. In: Journal of Nuclear Medicine. 2014 ; Vol. 55, No. 4. pp. 640-646.

Bibtex

@article{017bb77f8dec487e8824d055e402a76b,
title = "Radiosynthesis and in vivo evaluation of novel radioligands for PET imaging of cerebral 5-HT7 receptors",
abstract = "The serotonin (5-hydroxytryptamine [5-ΗΤ]) 7 receptor (5-HT7R) is the most recently discovered 5-HT receptor, and its physiologic and possible pathophysiologic roles are not fully elucidated. So far, no suitable 5-HT7R PET radioligand is available, thus limiting the investigation of this receptor in the living brain. Here, we present the radiosynthesis and in vivo evaluation of Cimbi-712 (3-{4-[4-(4-methylphenyl)piperazine-1-yl]butyl}p-1,3-dihydro-2H-indol-2-one) and Cimbi-717 (3-{4-[4-(3-methoxyphenyl)piperazine-1-yl]butyl}-1,3-dihydro-2H-indol-2-one) as selective 5-HT7R PET radioligands in the pig brain. The 5-HT7R distribution in the postmortem pig brain is also assessed.",
author = "Hansen, {Hanne D} and Herth, {Matthias M} and Anders Ettrup and Andersen, {Valdemar L} and Szabolcs Lehel and Agnete Dyssegaard and Kristensen, {Jesper Langgaard} and Knudsen, {Gitte M}",
year = "2014",
month = feb,
day = "24",
doi = "10.2967/jnumed.113.128983",
language = "English",
volume = "55",
pages = "640--646",
journal = "The Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine",
number = "4",

}

RIS

TY - JOUR

T1 - Radiosynthesis and in vivo evaluation of novel radioligands for PET imaging of cerebral 5-HT7 receptors

AU - Hansen, Hanne D

AU - Herth, Matthias M

AU - Ettrup, Anders

AU - Andersen, Valdemar L

AU - Lehel, Szabolcs

AU - Dyssegaard, Agnete

AU - Kristensen, Jesper Langgaard

AU - Knudsen, Gitte M

PY - 2014/2/24

Y1 - 2014/2/24

N2 - The serotonin (5-hydroxytryptamine [5-ΗΤ]) 7 receptor (5-HT7R) is the most recently discovered 5-HT receptor, and its physiologic and possible pathophysiologic roles are not fully elucidated. So far, no suitable 5-HT7R PET radioligand is available, thus limiting the investigation of this receptor in the living brain. Here, we present the radiosynthesis and in vivo evaluation of Cimbi-712 (3-{4-[4-(4-methylphenyl)piperazine-1-yl]butyl}p-1,3-dihydro-2H-indol-2-one) and Cimbi-717 (3-{4-[4-(3-methoxyphenyl)piperazine-1-yl]butyl}-1,3-dihydro-2H-indol-2-one) as selective 5-HT7R PET radioligands in the pig brain. The 5-HT7R distribution in the postmortem pig brain is also assessed.

AB - The serotonin (5-hydroxytryptamine [5-ΗΤ]) 7 receptor (5-HT7R) is the most recently discovered 5-HT receptor, and its physiologic and possible pathophysiologic roles are not fully elucidated. So far, no suitable 5-HT7R PET radioligand is available, thus limiting the investigation of this receptor in the living brain. Here, we present the radiosynthesis and in vivo evaluation of Cimbi-712 (3-{4-[4-(4-methylphenyl)piperazine-1-yl]butyl}p-1,3-dihydro-2H-indol-2-one) and Cimbi-717 (3-{4-[4-(3-methoxyphenyl)piperazine-1-yl]butyl}-1,3-dihydro-2H-indol-2-one) as selective 5-HT7R PET radioligands in the pig brain. The 5-HT7R distribution in the postmortem pig brain is also assessed.

U2 - 10.2967/jnumed.113.128983

DO - 10.2967/jnumed.113.128983

M3 - Journal article

C2 - 24566002

VL - 55

SP - 640

EP - 646

JO - The Journal of Nuclear Medicine

JF - The Journal of Nuclear Medicine

SN - 0161-5505

IS - 4

ER -

ID: 103038632