Randomised controlled trial of effect of fish-oil supplementation on pregnancy duration
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Randomised controlled trial of effect of fish-oil supplementation on pregnancy duration. / Olsen, S.F.; Sorensen, J.D.; Secher, N.J.; Hedegaard, M.; Henriksen, T.B.; Hansen, Harald S.; Grant, A.
In: Lancet, Vol. 339, No. 8800, 01.01.1992, p. 1003-1007.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Randomised controlled trial of effect of fish-oil supplementation on pregnancy duration
AU - Olsen, S.F.
AU - Sorensen, J.D.
AU - Secher, N.J.
AU - Hedegaard, M.
AU - Henriksen, T.B.
AU - Hansen, Harald S.
AU - Grant, A.
PY - 1992/1/1
Y1 - 1992/1/1
N2 - The high birthweights and long duration of pregnancy in the Faroe Islands led us to suggest that a high intake of marine-fat-derived n-3 fatty acids might prolong pregnancy by shifting the balance of production of prostaglandins involved in parturition. We have compared the effects on pregnancy duration, birthweight, and birth length of a fish-oil supplement, a control olive-oil supplement, and no supplementation. 533 healthy Danish women in week 30 of pregnancy were randomly assigned in a ratio of 2/1/1 to fish oil (four 1 g Pikasol capsules [containing 2.7 g n-3 fatty acids] per day), olive oil (four 1 g capsules per day), or no supplement. The three groups differed in mean length of gestation (p = 0.006), which was highest in the fish-oil group and lowest in the olive-oil group; the result was similar when the analysis was restricted to women with an estimate of gestation length based on early ultrasound findings (443 women). Pregnancies in the fish-oil group were on average 4.0 (95% confidence interval 1.5-6.4) days longer than those in the olive-oil group; the difference in birthweight was 107 (1-214) g. The effect of supplementation on length of gestation was influenced by intake of fish and of fish oil: the difference between fish-oil and other groups was increased by a low fish intake at baseline. Fish-oil supplementation in the third trimester seems to prolong pregnancy without detrimental effects on the growth of the fetus or on the course of labour.
AB - The high birthweights and long duration of pregnancy in the Faroe Islands led us to suggest that a high intake of marine-fat-derived n-3 fatty acids might prolong pregnancy by shifting the balance of production of prostaglandins involved in parturition. We have compared the effects on pregnancy duration, birthweight, and birth length of a fish-oil supplement, a control olive-oil supplement, and no supplementation. 533 healthy Danish women in week 30 of pregnancy were randomly assigned in a ratio of 2/1/1 to fish oil (four 1 g Pikasol capsules [containing 2.7 g n-3 fatty acids] per day), olive oil (four 1 g capsules per day), or no supplement. The three groups differed in mean length of gestation (p = 0.006), which was highest in the fish-oil group and lowest in the olive-oil group; the result was similar when the analysis was restricted to women with an estimate of gestation length based on early ultrasound findings (443 women). Pregnancies in the fish-oil group were on average 4.0 (95% confidence interval 1.5-6.4) days longer than those in the olive-oil group; the difference in birthweight was 107 (1-214) g. The effect of supplementation on length of gestation was influenced by intake of fish and of fish oil: the difference between fish-oil and other groups was increased by a low fish intake at baseline. Fish-oil supplementation in the third trimester seems to prolong pregnancy without detrimental effects on the growth of the fetus or on the course of labour.
UR - http://www.scopus.com/inward/record.url?scp=0026521616&partnerID=8YFLogxK
U2 - 10.1016/0140-6736(92)90533-9
DO - 10.1016/0140-6736(92)90533-9
M3 - Journal article
AN - SCOPUS:0026521616
VL - 339
SP - 1003
EP - 1007
JO - The Lancet
JF - The Lancet
SN - 0140-6736
IS - 8800
ER -
ID: 45561946