Recent advances in the medicinal chemistry of polyamine toxins
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Recent advances in the medicinal chemistry of polyamine toxins. / Strømgaard, K; Andersen, K; Krogsgaard-Larsen, P; Jaroszewski, J W.
In: Mini - Reviews in Medicinal Chemistry, Vol. 1, No. 4, 11.2001, p. 317-338.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Recent advances in the medicinal chemistry of polyamine toxins
AU - Strømgaard, K
AU - Andersen, K
AU - Krogsgaard-Larsen, P
AU - Jaroszewski, J W
PY - 2001/11
Y1 - 2001/11
N2 - This review describes the recent developments in the field of polyamine toxins, with focus on structure activity relationship investigations, including studies of importance of the polyamine moiety for biological activity, photolabeling studies using polyamine toxins as templates, as well as use of solid phase methods for the synthesis of polyamine toxins. The review is mainly concerned with effects of polyamine toxins on nicotinic acetylcholine receptors and ionotropic glutamate receptors.
AB - This review describes the recent developments in the field of polyamine toxins, with focus on structure activity relationship investigations, including studies of importance of the polyamine moiety for biological activity, photolabeling studies using polyamine toxins as templates, as well as use of solid phase methods for the synthesis of polyamine toxins. The review is mainly concerned with effects of polyamine toxins on nicotinic acetylcholine receptors and ionotropic glutamate receptors.
KW - Animals
KW - Humans
KW - Polyamines
KW - Quantitative Structure-Activity Relationship
KW - Spider Venoms
KW - Toxins, Biological
KW - Wasp Venoms
M3 - Journal article
C2 - 12369960
VL - 1
SP - 317
EP - 338
JO - Mini-Reviews in Medicinal Chemistry
JF - Mini-Reviews in Medicinal Chemistry
SN - 1389-5575
IS - 4
ER -
ID: 45823711