Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages. / Tsiamantas, Christos; Kwon, Sunbum; Rogers, Joseph M.; Douat, Céline; Huc, Ivan; Suga, Hiroaki.

In: Angewandte Chemie - International Edition, Vol. 59, No. 12, 16.03.2020, p. 4860-4864.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Tsiamantas, C, Kwon, S, Rogers, JM, Douat, C, Huc, I & Suga, H 2020, 'Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages', Angewandte Chemie - International Edition, vol. 59, no. 12, pp. 4860-4864. https://doi.org/10.1002/anie.201914654

APA

Tsiamantas, C., Kwon, S., Rogers, J. M., Douat, C., Huc, I., & Suga, H. (2020). Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages. Angewandte Chemie - International Edition, 59(12), 4860-4864. https://doi.org/10.1002/anie.201914654

Vancouver

Tsiamantas C, Kwon S, Rogers JM, Douat C, Huc I, Suga H. Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages. Angewandte Chemie - International Edition. 2020 Mar 16;59(12):4860-4864. https://doi.org/10.1002/anie.201914654

Author

Tsiamantas, Christos ; Kwon, Sunbum ; Rogers, Joseph M. ; Douat, Céline ; Huc, Ivan ; Suga, Hiroaki. / Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages. In: Angewandte Chemie - International Edition. 2020 ; Vol. 59, No. 12. pp. 4860-4864.

Bibtex

@article{532f7a4bb41d439792461a1b7ccab4d7,
title = "Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages",
abstract = "Derivatives of 4-aminomethyl-l-phenylalanine with aromatic oligoamide foldamers as sidechain appendages were successfully charged on tRNA by means of flexizymes. Their subsequent incorporation both at the C-terminus of, and within, peptide sequences by the ribosome, was demonstrated. These results expand the registry of chemical structures tolerated by the ribosome to sidechains significantly larger and more structurally defined than previously demonstrated.",
keywords = "flexizyme, foldamers, in vitro translation, peptides, peptidomimetics",
author = "Christos Tsiamantas and Sunbum Kwon and Rogers, {Joseph M.} and C{\'e}line Douat and Ivan Huc and Hiroaki Suga",
year = "2020",
month = mar,
day = "16",
doi = "10.1002/anie.201914654",
language = "English",
volume = "59",
pages = "4860--4864",
journal = "Angewandte Chemie International Edition",
issn = "1433-7851",
publisher = "Wiley-VCH Verlag GmbH & Co. KGaA",
number = "12",

}

RIS

TY - JOUR

T1 - Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages

AU - Tsiamantas, Christos

AU - Kwon, Sunbum

AU - Rogers, Joseph M.

AU - Douat, Céline

AU - Huc, Ivan

AU - Suga, Hiroaki

PY - 2020/3/16

Y1 - 2020/3/16

N2 - Derivatives of 4-aminomethyl-l-phenylalanine with aromatic oligoamide foldamers as sidechain appendages were successfully charged on tRNA by means of flexizymes. Their subsequent incorporation both at the C-terminus of, and within, peptide sequences by the ribosome, was demonstrated. These results expand the registry of chemical structures tolerated by the ribosome to sidechains significantly larger and more structurally defined than previously demonstrated.

AB - Derivatives of 4-aminomethyl-l-phenylalanine with aromatic oligoamide foldamers as sidechain appendages were successfully charged on tRNA by means of flexizymes. Their subsequent incorporation both at the C-terminus of, and within, peptide sequences by the ribosome, was demonstrated. These results expand the registry of chemical structures tolerated by the ribosome to sidechains significantly larger and more structurally defined than previously demonstrated.

KW - flexizyme

KW - foldamers

KW - in vitro translation

KW - peptides

KW - peptidomimetics

UR - http://www.scopus.com/inward/record.url?scp=85081103371&partnerID=8YFLogxK

U2 - 10.1002/anie.201914654

DO - 10.1002/anie.201914654

M3 - Journal article

C2 - 31894626

AN - SCOPUS:85081103371

VL - 59

SP - 4860

EP - 4864

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

SN - 1433-7851

IS - 12

ER -

ID: 243921596