Secretory phospholipase A2-mediated neuronal cell death involves glutamate ionotropic receptors

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Secretory phospholipase A2-mediated neuronal cell death involves glutamate ionotropic receptors. / Kolko, Miriam; de Turco, Elena B; Diemer, Nils Henrik; Bazan, Nicolas G.

In: NeuroReport, Vol. 13, No. 15, 28.10.2002, p. 1963-1966.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kolko, M, de Turco, EB, Diemer, NH & Bazan, NG 2002, 'Secretory phospholipase A2-mediated neuronal cell death involves glutamate ionotropic receptors', NeuroReport, vol. 13, no. 15, pp. 1963-1966. https://doi.org/10.1097/00001756-200210280-00026

APA

Kolko, M., de Turco, E. B., Diemer, N. H., & Bazan, N. G. (2002). Secretory phospholipase A2-mediated neuronal cell death involves glutamate ionotropic receptors. NeuroReport, 13(15), 1963-1966. https://doi.org/10.1097/00001756-200210280-00026

Vancouver

Kolko M, de Turco EB, Diemer NH, Bazan NG. Secretory phospholipase A2-mediated neuronal cell death involves glutamate ionotropic receptors. NeuroReport. 2002 Oct 28;13(15):1963-1966. https://doi.org/10.1097/00001756-200210280-00026

Author

Kolko, Miriam ; de Turco, Elena B ; Diemer, Nils Henrik ; Bazan, Nicolas G. / Secretory phospholipase A2-mediated neuronal cell death involves glutamate ionotropic receptors. In: NeuroReport. 2002 ; Vol. 13, No. 15. pp. 1963-1966.

Bibtex

@article{30339dea33984247a45ace08a618a6f8,
title = "Secretory phospholipase A2-mediated neuronal cell death involves glutamate ionotropic receptors",
abstract = "To define the significance of glutamate ionotropic receptors in sPLA -mediated neuronal cell death we used the NMDA receptor antagonist MK-801 and the AMPA receptor antagonist PNQX. In primary neuronal cell cultures both MK-801 and PNQX inhibited sPLA - and glutamate-induced neuronal death. [ H]Arachidonic acid release induced by both sPLA and glutamate was partially blocked by MK-801, indicating that the glutamate-NMDA-cPLA pathway contributes to sPLA -induced arachidonic acid release. Systemic administration of MK-801 to rats that had sPLA injected into the right striatum significantly decreased neuronal cell death. We conclude that glutamatergic synaptic activity modulates sPLA -induced neuronal cell death.",
keywords = "Animals, Arachidonic Acid, Astrocytes, Body Temperature, Brain, Cell Death, Cells, Cultured, Cerebral Infarction, Dizocilpine Maleate, Dose-Response Relationship, Drug, Excitatory Amino Acid Antagonists, Excitatory Amino Acids, Fetus, Group II Phospholipases A2, Humans, Neostriatum, Neurons, Phospholipases A, Phospholipases A2, Quinoxalines, Rats, Rats, Wistar, Receptors, AMPA, Receptors, N-Methyl-D-Aspartate",
author = "Miriam Kolko and {de Turco}, {Elena B} and Diemer, {Nils Henrik} and Bazan, {Nicolas G}",
year = "2002",
month = oct,
day = "28",
doi = "10.1097/00001756-200210280-00026",
language = "English",
volume = "13",
pages = "1963--1966",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams & Wilkins",
number = "15",

}

RIS

TY - JOUR

T1 - Secretory phospholipase A2-mediated neuronal cell death involves glutamate ionotropic receptors

AU - Kolko, Miriam

AU - de Turco, Elena B

AU - Diemer, Nils Henrik

AU - Bazan, Nicolas G

PY - 2002/10/28

Y1 - 2002/10/28

N2 - To define the significance of glutamate ionotropic receptors in sPLA -mediated neuronal cell death we used the NMDA receptor antagonist MK-801 and the AMPA receptor antagonist PNQX. In primary neuronal cell cultures both MK-801 and PNQX inhibited sPLA - and glutamate-induced neuronal death. [ H]Arachidonic acid release induced by both sPLA and glutamate was partially blocked by MK-801, indicating that the glutamate-NMDA-cPLA pathway contributes to sPLA -induced arachidonic acid release. Systemic administration of MK-801 to rats that had sPLA injected into the right striatum significantly decreased neuronal cell death. We conclude that glutamatergic synaptic activity modulates sPLA -induced neuronal cell death.

AB - To define the significance of glutamate ionotropic receptors in sPLA -mediated neuronal cell death we used the NMDA receptor antagonist MK-801 and the AMPA receptor antagonist PNQX. In primary neuronal cell cultures both MK-801 and PNQX inhibited sPLA - and glutamate-induced neuronal death. [ H]Arachidonic acid release induced by both sPLA and glutamate was partially blocked by MK-801, indicating that the glutamate-NMDA-cPLA pathway contributes to sPLA -induced arachidonic acid release. Systemic administration of MK-801 to rats that had sPLA injected into the right striatum significantly decreased neuronal cell death. We conclude that glutamatergic synaptic activity modulates sPLA -induced neuronal cell death.

KW - Animals

KW - Arachidonic Acid

KW - Astrocytes

KW - Body Temperature

KW - Brain

KW - Cell Death

KW - Cells, Cultured

KW - Cerebral Infarction

KW - Dizocilpine Maleate

KW - Dose-Response Relationship, Drug

KW - Excitatory Amino Acid Antagonists

KW - Excitatory Amino Acids

KW - Fetus

KW - Group II Phospholipases A2

KW - Humans

KW - Neostriatum

KW - Neurons

KW - Phospholipases A

KW - Phospholipases A2

KW - Quinoxalines

KW - Rats

KW - Rats, Wistar

KW - Receptors, AMPA

KW - Receptors, N-Methyl-D-Aspartate

U2 - 10.1097/00001756-200210280-00026

DO - 10.1097/00001756-200210280-00026

M3 - Journal article

C2 - 12395100

VL - 13

SP - 1963

EP - 1966

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 15

ER -

ID: 128615058