Selected strategies to fight pathogenic bacteria
Research output: Contribution to journal › Review › Research › peer-review
Standard
Selected strategies to fight pathogenic bacteria. / Plotniece, Aiva; Sobolev, Arkadij; Supuran, Claudiu T; Carta, Fabrizio; Björkling, Fredrik; Franzyk, Henrik; Yli-Kauhaluoma, Jari; Augustyns, Koen; Cos, Paul; De Vooght, Linda; Govaerts, Matthias; Aizawa, Juliana; Tammela, Päivi; Žalubovskis, Raivis.
In: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 38, No. 1, 2155816, 2023.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Selected strategies to fight pathogenic bacteria
AU - Plotniece, Aiva
AU - Sobolev, Arkadij
AU - Supuran, Claudiu T
AU - Carta, Fabrizio
AU - Björkling, Fredrik
AU - Franzyk, Henrik
AU - Yli-Kauhaluoma, Jari
AU - Augustyns, Koen
AU - Cos, Paul
AU - De Vooght, Linda
AU - Govaerts, Matthias
AU - Aizawa, Juliana
AU - Tammela, Päivi
AU - Žalubovskis, Raivis
PY - 2023
Y1 - 2023
N2 - Natural products and analogues are a source of antibacterial drug discovery. Considering drug resistance levels emerging for antibiotics, identification of bacterial metalloenzymes and the synthesis of selective inhibitors are interesting for antibacterial agent development. Peptide nucleic acids are attractive antisense and antigene agents representing a novel strategy to target pathogens due to their unique mechanism of action. Antisense inhibition and development of antisense peptide nucleic acids is a new approach to antibacterial agents. Due to the increased resistance of biofilms to antibiotics, alternative therapeutic options are necessary. To develop antimicrobial strategies, optimised in vitro and in vivo models are needed. In vivo models to study biofilm-related respiratory infections, device-related infections: ventilator-associated pneumonia, tissue-related infections: chronic infection models based on alginate or agar beads, methods to battle biofilm-related infections are discussed. Drug delivery in case of antibacterials often is a serious issue therefore this review includes overview of drug delivery nanosystems.
AB - Natural products and analogues are a source of antibacterial drug discovery. Considering drug resistance levels emerging for antibiotics, identification of bacterial metalloenzymes and the synthesis of selective inhibitors are interesting for antibacterial agent development. Peptide nucleic acids are attractive antisense and antigene agents representing a novel strategy to target pathogens due to their unique mechanism of action. Antisense inhibition and development of antisense peptide nucleic acids is a new approach to antibacterial agents. Due to the increased resistance of biofilms to antibiotics, alternative therapeutic options are necessary. To develop antimicrobial strategies, optimised in vitro and in vivo models are needed. In vivo models to study biofilm-related respiratory infections, device-related infections: ventilator-associated pneumonia, tissue-related infections: chronic infection models based on alginate or agar beads, methods to battle biofilm-related infections are discussed. Drug delivery in case of antibacterials often is a serious issue therefore this review includes overview of drug delivery nanosystems.
KW - Peptide Nucleic Acids
KW - Bacteria
KW - Anti-Infective Agents
KW - Anti-Bacterial Agents/pharmacology
KW - Biofilms
U2 - 10.1080/14756366.2022.2155816
DO - 10.1080/14756366.2022.2155816
M3 - Review
C2 - 36629427
VL - 38
JO - Journal of Enzyme Inhibition and Medicinal Chemistry
JF - Journal of Enzyme Inhibition and Medicinal Chemistry
SN - 1475-6366
IS - 1
M1 - 2155816
ER -
ID: 332611667