Serrulatane diterpenoids from the leaves of Eremophila glabra and their potential as antihyperglycemic drug leads

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Standard

Serrulatane diterpenoids from the leaves of Eremophila glabra and their potential as antihyperglycemic drug leads. / Petersen, Malene Johanne; Liang, Chao; Kjaerulff, Louise; Ndi, Chi; Semple, Susan; Buirchell, Bevan; Coriani, Sonia; Møller, Birger Lindberg; Stærk, Dan.

In: Phytochemistry, Vol. 196, 113072, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Petersen, MJ, Liang, C, Kjaerulff, L, Ndi, C, Semple, S, Buirchell, B, Coriani, S, Møller, BL & Stærk, D 2022, 'Serrulatane diterpenoids from the leaves of Eremophila glabra and their potential as antihyperglycemic drug leads', Phytochemistry, vol. 196, 113072. https://doi.org/10.1016/j.phytochem.2021.113072

APA

Petersen, M. J., Liang, C., Kjaerulff, L., Ndi, C., Semple, S., Buirchell, B., Coriani, S., Møller, B. L., & Stærk, D. (2022). Serrulatane diterpenoids from the leaves of Eremophila glabra and their potential as antihyperglycemic drug leads. Phytochemistry, 196, [113072]. https://doi.org/10.1016/j.phytochem.2021.113072

Vancouver

Petersen MJ, Liang C, Kjaerulff L, Ndi C, Semple S, Buirchell B et al. Serrulatane diterpenoids from the leaves of Eremophila glabra and their potential as antihyperglycemic drug leads. Phytochemistry. 2022;196. 113072. https://doi.org/10.1016/j.phytochem.2021.113072

Author

Petersen, Malene Johanne ; Liang, Chao ; Kjaerulff, Louise ; Ndi, Chi ; Semple, Susan ; Buirchell, Bevan ; Coriani, Sonia ; Møller, Birger Lindberg ; Stærk, Dan. / Serrulatane diterpenoids from the leaves of Eremophila glabra and their potential as antihyperglycemic drug leads. In: Phytochemistry. 2022 ; Vol. 196.

Bibtex

@article{e4c45b8b344945df8a9fdad6d983b1b4,
title = "Serrulatane diterpenoids from the leaves of Eremophila glabra and their potential as antihyperglycemic drug leads",
abstract = "Eremophila (Scrophulariaceae) is a genus of Australian desert plants, which have been used by Australian Aboriginal people for various medicinal purposes. Crude extracts of the leaf resin of Eremophila glabra (R.Br.) Ostenf. showed α-glucosidase and protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with IC50 values of 19.3 ± 1.2 μg/mL and 11.8 ± 2.1 μg/mL, respectively. Dual α-glucosidase/PTP1B high-resolution inhibition profiling combined with HPLC-PDA-HRMS and NMR were used to isolate and identify the compounds providing these activities. This resulted in isolation of seven undescribed serrulatane diterpenoids, eremoglabrane A-G, together with nine previously identified serrulatane diterpenoids and flavonoids. Three of the serrulatane diterpenoids showed PTP1B inhibitory activities with IC50 values from 63.8 ± 5.8 μM to 104.5 ± 25.9 μM.",
author = "Petersen, {Malene Johanne} and Chao Liang and Louise Kjaerulff and Chi Ndi and Susan Semple and Bevan Buirchell and Sonia Coriani and M{\o}ller, {Birger Lindberg} and Dan St{\ae}rk",
year = "2022",
doi = "10.1016/j.phytochem.2021.113072",
language = "English",
volume = "196",
journal = "Phytochemistry",
issn = "0031-9422",
publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Serrulatane diterpenoids from the leaves of Eremophila glabra and their potential as antihyperglycemic drug leads

AU - Petersen, Malene Johanne

AU - Liang, Chao

AU - Kjaerulff, Louise

AU - Ndi, Chi

AU - Semple, Susan

AU - Buirchell, Bevan

AU - Coriani, Sonia

AU - Møller, Birger Lindberg

AU - Stærk, Dan

PY - 2022

Y1 - 2022

N2 - Eremophila (Scrophulariaceae) is a genus of Australian desert plants, which have been used by Australian Aboriginal people for various medicinal purposes. Crude extracts of the leaf resin of Eremophila glabra (R.Br.) Ostenf. showed α-glucosidase and protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with IC50 values of 19.3 ± 1.2 μg/mL and 11.8 ± 2.1 μg/mL, respectively. Dual α-glucosidase/PTP1B high-resolution inhibition profiling combined with HPLC-PDA-HRMS and NMR were used to isolate and identify the compounds providing these activities. This resulted in isolation of seven undescribed serrulatane diterpenoids, eremoglabrane A-G, together with nine previously identified serrulatane diterpenoids and flavonoids. Three of the serrulatane diterpenoids showed PTP1B inhibitory activities with IC50 values from 63.8 ± 5.8 μM to 104.5 ± 25.9 μM.

AB - Eremophila (Scrophulariaceae) is a genus of Australian desert plants, which have been used by Australian Aboriginal people for various medicinal purposes. Crude extracts of the leaf resin of Eremophila glabra (R.Br.) Ostenf. showed α-glucosidase and protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with IC50 values of 19.3 ± 1.2 μg/mL and 11.8 ± 2.1 μg/mL, respectively. Dual α-glucosidase/PTP1B high-resolution inhibition profiling combined with HPLC-PDA-HRMS and NMR were used to isolate and identify the compounds providing these activities. This resulted in isolation of seven undescribed serrulatane diterpenoids, eremoglabrane A-G, together with nine previously identified serrulatane diterpenoids and flavonoids. Three of the serrulatane diterpenoids showed PTP1B inhibitory activities with IC50 values from 63.8 ± 5.8 μM to 104.5 ± 25.9 μM.

U2 - 10.1016/j.phytochem.2021.113072

DO - 10.1016/j.phytochem.2021.113072

M3 - Journal article

C2 - 34973506

VL - 196

JO - Phytochemistry

JF - Phytochemistry

SN - 0031-9422

M1 - 113072

ER -

ID: 287999202