Sesquiterpenes from Thapsia nitida var. meridionalis and Thapsia nitida var. nitida
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Sesquiterpenes from Thapsia nitida var. meridionalis and Thapsia nitida var. nitida. / Rubal, Juan J; Guerra, Francisco M; Moreno-Dorado, F Javier; Jorge, Zacarías D; Massanet, Guillermo M; Søhoel, Helmer; Smitt, Ulla W; Frydenvang, Karla Andrea; Christensen, S Brøgger; Nielsen, Charlotte; Eriksson, Margit.
In: Journal of Natural Products, Vol. 69, No. 11, 2006, p. 1566-71.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Sesquiterpenes from Thapsia nitida var. meridionalis and Thapsia nitida var. nitida
AU - Rubal, Juan J
AU - Guerra, Francisco M
AU - Moreno-Dorado, F Javier
AU - Jorge, Zacarías D
AU - Massanet, Guillermo M
AU - Søhoel, Helmer
AU - Smitt, Ulla W
AU - Frydenvang, Karla Andrea
AU - Christensen, S Brøgger
AU - Nielsen, Charlotte
AU - Eriksson, Margit
PY - 2006
Y1 - 2006
N2 - Nine new eudesmanolides (1-9), two new guaianolides (12 and 13), and a new germacrane (10), along with a previously reported guaianolide (11), have been isolated from the roots of Thapsia nitida var. meridionalis. Thapsia nitida var. nitida also afforded compound 13 along with a new guaianolide (14). The structure of 13 was confirmed by X-ray crystallographic analysis. Compounds 1, 2, and 11-14 have been tested as potential inhibitors of the sarco- and endoplasmic Ca2+-dependent ATPases (SERCA) pump. None of them showed significant activities.
AB - Nine new eudesmanolides (1-9), two new guaianolides (12 and 13), and a new germacrane (10), along with a previously reported guaianolide (11), have been isolated from the roots of Thapsia nitida var. meridionalis. Thapsia nitida var. nitida also afforded compound 13 along with a new guaianolide (14). The structure of 13 was confirmed by X-ray crystallographic analysis. Compounds 1, 2, and 11-14 have been tested as potential inhibitors of the sarco- and endoplasmic Ca2+-dependent ATPases (SERCA) pump. None of them showed significant activities.
KW - Crystallography, X-Ray
KW - Molecular Conformation
KW - Molecular Structure
KW - Plant Roots
KW - Plants, Medicinal
KW - Sarcoplasmic Reticulum Calcium-Transporting ATPases
KW - Sesquiterpenes
KW - Spain
KW - Thapsia
U2 - 10.1021/np0603065
DO - 10.1021/np0603065
M3 - Journal article
C2 - 17125222
VL - 69
SP - 1566
EP - 1571
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 11
ER -
ID: 40370954