Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. / Fredriksson, Robert; Höglund, Pär J; Gloriam, David E.; Lagerström, Malin C; Schiöth, Helgi B.

In: F E B S Letters, Vol. 554, No. 3, 20.11.2003, p. 381-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Fredriksson, R, Höglund, PJ, Gloriam, DE, Lagerström, MC & Schiöth, HB 2003, 'Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives', F E B S Letters, vol. 554, no. 3, pp. 381-8.

APA

Fredriksson, R., Höglund, P. J., Gloriam, D. E., Lagerström, M. C., & Schiöth, H. B. (2003). Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. F E B S Letters, 554(3), 381-8.

Vancouver

Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. F E B S Letters. 2003 Nov 20;554(3):381-8.

Author

Fredriksson, Robert ; Höglund, Pär J ; Gloriam, David E. ; Lagerström, Malin C ; Schiöth, Helgi B. / Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. In: F E B S Letters. 2003 ; Vol. 554, No. 3. pp. 381-8.

Bibtex

@article{a6abc9a6bba441f6b52d814a4ea25550,
title = "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives",
abstract = "We report seven new members of the superfamily of human G protein-coupled receptors (GPCRs) found by searches in the human genome databases, termed GPR100, GPR119, GPR120, GPR135, GPR136, GPR141, and GPR142. We also report 16 orthologues of these receptors in mouse, rat, fugu (pufferfish) and zebrafish. Phylogenetic analysis shows that these are additional members of the family of rhodopsin-type GPCRs. GPR100 shows similarity with the orphan receptor SALPR. Remarkably, the other receptors do not have any close relative among other known human rhodopsin-like GPCRs. Most of these orphan receptors are highly conserved through several vertebrate species and are present in single copies. Analysis of expressed sequence tag (EST) sequences indicated individual expression patterns, such as for GPR135, which was found in a wide variety of tissues including eye, brain, cervix, stomach and testis. Several ESTs for GPR141 were found in marrow and cancer cells, while the other receptors seem to have more restricted expression patterns.",
keywords = "Amino Acid Sequence, Animals, Databases, Protein, Evolution, Molecular, Expressed Sequence Tags, Gene Expression, Genome, Human, Humans, Mice, Molecular Sequence Data, Organ Specificity, Phylogeny, Rats, Receptors, G-Protein-Coupled, Rhodopsin, Sequence Alignment, Sequence Homology, Amino Acid, Takifugu, Zebrafish",
author = "Robert Fredriksson and H{\"o}glund, {P{\"a}r J} and Gloriam, {David E.} and Lagerstr{\"o}m, {Malin C} and Schi{\"o}th, {Helgi B}",
year = "2003",
month = nov,
day = "20",
language = "English",
volume = "554",
pages = "381--8",
journal = "F E B S Letters",
issn = "0014-5793",
publisher = "JohnWiley & Sons Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives

AU - Fredriksson, Robert

AU - Höglund, Pär J

AU - Gloriam, David E.

AU - Lagerström, Malin C

AU - Schiöth, Helgi B

PY - 2003/11/20

Y1 - 2003/11/20

N2 - We report seven new members of the superfamily of human G protein-coupled receptors (GPCRs) found by searches in the human genome databases, termed GPR100, GPR119, GPR120, GPR135, GPR136, GPR141, and GPR142. We also report 16 orthologues of these receptors in mouse, rat, fugu (pufferfish) and zebrafish. Phylogenetic analysis shows that these are additional members of the family of rhodopsin-type GPCRs. GPR100 shows similarity with the orphan receptor SALPR. Remarkably, the other receptors do not have any close relative among other known human rhodopsin-like GPCRs. Most of these orphan receptors are highly conserved through several vertebrate species and are present in single copies. Analysis of expressed sequence tag (EST) sequences indicated individual expression patterns, such as for GPR135, which was found in a wide variety of tissues including eye, brain, cervix, stomach and testis. Several ESTs for GPR141 were found in marrow and cancer cells, while the other receptors seem to have more restricted expression patterns.

AB - We report seven new members of the superfamily of human G protein-coupled receptors (GPCRs) found by searches in the human genome databases, termed GPR100, GPR119, GPR120, GPR135, GPR136, GPR141, and GPR142. We also report 16 orthologues of these receptors in mouse, rat, fugu (pufferfish) and zebrafish. Phylogenetic analysis shows that these are additional members of the family of rhodopsin-type GPCRs. GPR100 shows similarity with the orphan receptor SALPR. Remarkably, the other receptors do not have any close relative among other known human rhodopsin-like GPCRs. Most of these orphan receptors are highly conserved through several vertebrate species and are present in single copies. Analysis of expressed sequence tag (EST) sequences indicated individual expression patterns, such as for GPR135, which was found in a wide variety of tissues including eye, brain, cervix, stomach and testis. Several ESTs for GPR141 were found in marrow and cancer cells, while the other receptors seem to have more restricted expression patterns.

KW - Amino Acid Sequence

KW - Animals

KW - Databases, Protein

KW - Evolution, Molecular

KW - Expressed Sequence Tags

KW - Gene Expression

KW - Genome, Human

KW - Humans

KW - Mice

KW - Molecular Sequence Data

KW - Organ Specificity

KW - Phylogeny

KW - Rats

KW - Receptors, G-Protein-Coupled

KW - Rhodopsin

KW - Sequence Alignment

KW - Sequence Homology, Amino Acid

KW - Takifugu

KW - Zebrafish

M3 - Journal article

C2 - 14623098

VL - 554

SP - 381

EP - 388

JO - F E B S Letters

JF - F E B S Letters

SN - 0014-5793

IS - 3

ER -

ID: 45811736