Sex peptide regulates female receptivity in Drosophila through serotoninergic neurons

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Sex peptide regulates female receptivity in Drosophila through serotoninergic neurons. / Yang, Yan tong; Hu, Shao Wei; Li, Xiaonan; Sun, Yuanjie; He, Ping; Kohlmeier, Kristi Anne; Zhu, Yan.

In: iScience, Vol. 26, No. 3, 106123, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Yang, YT, Hu, SW, Li, X, Sun, Y, He, P, Kohlmeier, KA & Zhu, Y 2023, 'Sex peptide regulates female receptivity in Drosophila through serotoninergic neurons', iScience, vol. 26, no. 3, 106123. https://doi.org/10.1016/j.isci.2023.106123

APA

Yang, Y. T., Hu, S. W., Li, X., Sun, Y., He, P., Kohlmeier, K. A., & Zhu, Y. (2023). Sex peptide regulates female receptivity in Drosophila through serotoninergic neurons. iScience, 26(3), [106123]. https://doi.org/10.1016/j.isci.2023.106123

Vancouver

Yang YT, Hu SW, Li X, Sun Y, He P, Kohlmeier KA et al. Sex peptide regulates female receptivity in Drosophila through serotoninergic neurons. iScience. 2023;26(3). 106123. https://doi.org/10.1016/j.isci.2023.106123

Author

Yang, Yan tong ; Hu, Shao Wei ; Li, Xiaonan ; Sun, Yuanjie ; He, Ping ; Kohlmeier, Kristi Anne ; Zhu, Yan. / Sex peptide regulates female receptivity in Drosophila through serotoninergic neurons. In: iScience. 2023 ; Vol. 26, No. 3.

Bibtex

@article{987e53db229c43d6aa8b3daa0e302fa3,
title = "Sex peptide regulates female receptivity in Drosophila through serotoninergic neurons",
abstract = "The courtship ritual is a dynamic interplay between males and females. Courtship successfully leading to copulation is determined by the intention of both parties which is conveyed by complex action sequences. In Drosophila, the neural mechanisms controlling the female{\textquoteright}s willingness to mate, or sexual receptivity, have only recently become the focus of investigations. Here we report that pre-mating sexual receptivity in females requires activity within a subset of serotoninergic neurons (SPN), which positively regulate courtship success. Interestingly, a male-derived sex peptide, SP, which was transferred to females during copulation acted to inhibit the activity of SPN neurons and suppressed receptivity. Downstream of 5-HT, subsets of 5-HT7 receptor neurons played critical roles in SP-induced suppression of sexual receptivity. Together, our study reveals a complex serotonin signaling system in the central brain of Drosophila which manages the female{\textquoteright}s desire to mate.",
author = "Yang, {Yan tong} and Hu, {Shao Wei} and Xiaonan Li and Yuanjie Sun and Ping He and Kohlmeier, {Kristi Anne} and Yan Zhu",
year = "2023",
doi = "10.1016/j.isci.2023.106123",
language = "English",
volume = "26",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Sex peptide regulates female receptivity in Drosophila through serotoninergic neurons

AU - Yang, Yan tong

AU - Hu, Shao Wei

AU - Li, Xiaonan

AU - Sun, Yuanjie

AU - He, Ping

AU - Kohlmeier, Kristi Anne

AU - Zhu, Yan

PY - 2023

Y1 - 2023

N2 - The courtship ritual is a dynamic interplay between males and females. Courtship successfully leading to copulation is determined by the intention of both parties which is conveyed by complex action sequences. In Drosophila, the neural mechanisms controlling the female’s willingness to mate, or sexual receptivity, have only recently become the focus of investigations. Here we report that pre-mating sexual receptivity in females requires activity within a subset of serotoninergic neurons (SPN), which positively regulate courtship success. Interestingly, a male-derived sex peptide, SP, which was transferred to females during copulation acted to inhibit the activity of SPN neurons and suppressed receptivity. Downstream of 5-HT, subsets of 5-HT7 receptor neurons played critical roles in SP-induced suppression of sexual receptivity. Together, our study reveals a complex serotonin signaling system in the central brain of Drosophila which manages the female’s desire to mate.

AB - The courtship ritual is a dynamic interplay between males and females. Courtship successfully leading to copulation is determined by the intention of both parties which is conveyed by complex action sequences. In Drosophila, the neural mechanisms controlling the female’s willingness to mate, or sexual receptivity, have only recently become the focus of investigations. Here we report that pre-mating sexual receptivity in females requires activity within a subset of serotoninergic neurons (SPN), which positively regulate courtship success. Interestingly, a male-derived sex peptide, SP, which was transferred to females during copulation acted to inhibit the activity of SPN neurons and suppressed receptivity. Downstream of 5-HT, subsets of 5-HT7 receptor neurons played critical roles in SP-induced suppression of sexual receptivity. Together, our study reveals a complex serotonin signaling system in the central brain of Drosophila which manages the female’s desire to mate.

U2 - 10.1016/j.isci.2023.106123

DO - 10.1016/j.isci.2023.106123

M3 - Journal article

C2 - 36876123

VL - 26

JO - iScience

JF - iScience

SN - 2589-0042

IS - 3

M1 - 106123

ER -

ID: 333170467