Side-chain-anchored N(alpha)-Fmoc-Tyr-OPfp for bidirectional solid-phase synthesis

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Side-chain-anchored N(alpha)-Fmoc-Tyr-OPfp for bidirectional solid-phase synthesis. / Olsen, Christian A; Jørgensen, Malene; Hansen, Steen H; Witt, Matthias; Jaroszewski, Jerzy W; Franzyk, Henrik.

In: Organic Letters, Vol. 7, No. 9, 2005, p. 1703-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Olsen, CA, Jørgensen, M, Hansen, SH, Witt, M, Jaroszewski, JW & Franzyk, H 2005, 'Side-chain-anchored N(alpha)-Fmoc-Tyr-OPfp for bidirectional solid-phase synthesis', Organic Letters, vol. 7, no. 9, pp. 1703-6. https://doi.org/10.1021/ol050305o

APA

Olsen, C. A., Jørgensen, M., Hansen, S. H., Witt, M., Jaroszewski, J. W., & Franzyk, H. (2005). Side-chain-anchored N(alpha)-Fmoc-Tyr-OPfp for bidirectional solid-phase synthesis. Organic Letters, 7(9), 1703-6. https://doi.org/10.1021/ol050305o

Vancouver

Olsen CA, Jørgensen M, Hansen SH, Witt M, Jaroszewski JW, Franzyk H. Side-chain-anchored N(alpha)-Fmoc-Tyr-OPfp for bidirectional solid-phase synthesis. Organic Letters. 2005;7(9):1703-6. https://doi.org/10.1021/ol050305o

Author

Olsen, Christian A ; Jørgensen, Malene ; Hansen, Steen H ; Witt, Matthias ; Jaroszewski, Jerzy W ; Franzyk, Henrik. / Side-chain-anchored N(alpha)-Fmoc-Tyr-OPfp for bidirectional solid-phase synthesis. In: Organic Letters. 2005 ; Vol. 7, No. 9. pp. 1703-6.

Bibtex

@article{1d895ec3cd0b42fbae50b9867fbc3aee,
title = "Side-chain-anchored N(alpha)-Fmoc-Tyr-OPfp for bidirectional solid-phase synthesis",
abstract = "[reaction: see text] A mild resin-immobilization strategy employing a readily prepared trityl bromide resin for anchoring building blocks via a phenol group has been developed. With N(alpha)-Fmoc-Tyr-OPfp as a starter building block, it was possible to prepare asymmetrically substituted hybrids of spider- and wasp-type polyamine toxins using solid-phase peptide synthesis conditions.",
keywords = "Combinatorial Chemistry Techniques, Fluorobenzenes, Models, Molecular, Molecular Structure, Oligopeptides, Spider Venoms, Tyrosine, Wasp Venoms",
author = "Olsen, {Christian A} and Malene J{\o}rgensen and Hansen, {Steen H} and Matthias Witt and Jaroszewski, {Jerzy W} and Henrik Franzyk",
year = "2005",
doi = "10.1021/ol050305o",
language = "English",
volume = "7",
pages = "1703--6",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "9",

}

RIS

TY - JOUR

T1 - Side-chain-anchored N(alpha)-Fmoc-Tyr-OPfp for bidirectional solid-phase synthesis

AU - Olsen, Christian A

AU - Jørgensen, Malene

AU - Hansen, Steen H

AU - Witt, Matthias

AU - Jaroszewski, Jerzy W

AU - Franzyk, Henrik

PY - 2005

Y1 - 2005

N2 - [reaction: see text] A mild resin-immobilization strategy employing a readily prepared trityl bromide resin for anchoring building blocks via a phenol group has been developed. With N(alpha)-Fmoc-Tyr-OPfp as a starter building block, it was possible to prepare asymmetrically substituted hybrids of spider- and wasp-type polyamine toxins using solid-phase peptide synthesis conditions.

AB - [reaction: see text] A mild resin-immobilization strategy employing a readily prepared trityl bromide resin for anchoring building blocks via a phenol group has been developed. With N(alpha)-Fmoc-Tyr-OPfp as a starter building block, it was possible to prepare asymmetrically substituted hybrids of spider- and wasp-type polyamine toxins using solid-phase peptide synthesis conditions.

KW - Combinatorial Chemistry Techniques

KW - Fluorobenzenes

KW - Models, Molecular

KW - Molecular Structure

KW - Oligopeptides

KW - Spider Venoms

KW - Tyrosine

KW - Wasp Venoms

U2 - 10.1021/ol050305o

DO - 10.1021/ol050305o

M3 - Journal article

C2 - 15844885

VL - 7

SP - 1703

EP - 1706

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 9

ER -

ID: 42359494