Synergism between thapsigargin and the phorbol ester 12-O-tetradecanoylphorbol 13-acetate on the release of [C]arachidonic acid and histamine from rat peritoneal mast cells

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Synergism between thapsigargin and the phorbol ester 12-O-tetradecanoylphorbol 13-acetate on the release of [C]arachidonic acid and histamine from rat peritoneal mast cells. / Jacobsen, S.; Hansen, Harald S.; Jensen, B.

In: Biochemical Pharmacology, Vol. 36, No. 5, 01.03.1987, p. 621-626.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jacobsen, S, Hansen, HS & Jensen, B 1987, 'Synergism between thapsigargin and the phorbol ester 12-O-tetradecanoylphorbol 13-acetate on the release of [C]arachidonic acid and histamine from rat peritoneal mast cells', Biochemical Pharmacology, vol. 36, no. 5, pp. 621-626.

APA

Jacobsen, S., Hansen, H. S., & Jensen, B. (1987). Synergism between thapsigargin and the phorbol ester 12-O-tetradecanoylphorbol 13-acetate on the release of [C]arachidonic acid and histamine from rat peritoneal mast cells. Biochemical Pharmacology, 36(5), 621-626.

Vancouver

Jacobsen S, Hansen HS, Jensen B. Synergism between thapsigargin and the phorbol ester 12-O-tetradecanoylphorbol 13-acetate on the release of [C]arachidonic acid and histamine from rat peritoneal mast cells. Biochemical Pharmacology. 1987 Mar 1;36(5):621-626.

Author

Jacobsen, S. ; Hansen, Harald S. ; Jensen, B. / Synergism between thapsigargin and the phorbol ester 12-O-tetradecanoylphorbol 13-acetate on the release of [C]arachidonic acid and histamine from rat peritoneal mast cells. In: Biochemical Pharmacology. 1987 ; Vol. 36, No. 5. pp. 621-626.

Bibtex

@article{74b861450b91424e8b8e8f60d210b61a,
title = "Synergism between thapsigargin and the phorbol ester 12-O-tetradecanoylphorbol 13-acetate on the release of [C]arachidonic acid and histamine from rat peritoneal mast cells",
abstract = "Thapsigargin is a potent skin irritating sesquiterpene lactone isolated from the roots of Thapsia garganica L. (Apiaceae). In rat peritoneal mast cells thapsigargin induced a calcium-dependent non-cytotoxic [C]arachidonic acid and histamine release. A minor amount of the released [C]arachidonic acid was converted to [C]prostaglandin D. A potentiated effect was found between thapsigargin and 12--tetradecanoylphorbol 13-acetate, as well as between A23187 and the phorbol ester with respect to release of [C]arachidonic acid and histamine. It is suggested that the synergistic effect is due to activation of protein kinase C by 12-O-tetradecanoylphorbol 13-acetate and to increased intracellular calcium concentration mediated by A23187 as well as thapsigargin. [C]arachidonic acid was released mainly from phosphatidylcholine. It is suggested that this release may be due to an action of phospholipase A, and that protein kinase C is involved in activation of phospholipase A.",
author = "S. Jacobsen and Hansen, {Harald S.} and B. Jensen",
year = "1987",
month = mar,
day = "1",
language = "English",
volume = "36",
pages = "621--626",
journal = "Biochemical Pharmacology",
issn = "0006-2952",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - Synergism between thapsigargin and the phorbol ester 12-O-tetradecanoylphorbol 13-acetate on the release of [C]arachidonic acid and histamine from rat peritoneal mast cells

AU - Jacobsen, S.

AU - Hansen, Harald S.

AU - Jensen, B.

PY - 1987/3/1

Y1 - 1987/3/1

N2 - Thapsigargin is a potent skin irritating sesquiterpene lactone isolated from the roots of Thapsia garganica L. (Apiaceae). In rat peritoneal mast cells thapsigargin induced a calcium-dependent non-cytotoxic [C]arachidonic acid and histamine release. A minor amount of the released [C]arachidonic acid was converted to [C]prostaglandin D. A potentiated effect was found between thapsigargin and 12--tetradecanoylphorbol 13-acetate, as well as between A23187 and the phorbol ester with respect to release of [C]arachidonic acid and histamine. It is suggested that the synergistic effect is due to activation of protein kinase C by 12-O-tetradecanoylphorbol 13-acetate and to increased intracellular calcium concentration mediated by A23187 as well as thapsigargin. [C]arachidonic acid was released mainly from phosphatidylcholine. It is suggested that this release may be due to an action of phospholipase A, and that protein kinase C is involved in activation of phospholipase A.

AB - Thapsigargin is a potent skin irritating sesquiterpene lactone isolated from the roots of Thapsia garganica L. (Apiaceae). In rat peritoneal mast cells thapsigargin induced a calcium-dependent non-cytotoxic [C]arachidonic acid and histamine release. A minor amount of the released [C]arachidonic acid was converted to [C]prostaglandin D. A potentiated effect was found between thapsigargin and 12--tetradecanoylphorbol 13-acetate, as well as between A23187 and the phorbol ester with respect to release of [C]arachidonic acid and histamine. It is suggested that the synergistic effect is due to activation of protein kinase C by 12-O-tetradecanoylphorbol 13-acetate and to increased intracellular calcium concentration mediated by A23187 as well as thapsigargin. [C]arachidonic acid was released mainly from phosphatidylcholine. It is suggested that this release may be due to an action of phospholipase A, and that protein kinase C is involved in activation of phospholipase A.

UR - http://www.scopus.com/inward/record.url?scp=0023153203&partnerID=8YFLogxK

M3 - Journal article

AN - SCOPUS:0023153203

VL - 36

SP - 621

EP - 626

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

SN - 0006-2952

IS - 5

ER -

ID: 45561308