Synthesis and biological evaluation of novel pyrazolyl-2,4-thiazolidinediones as anti-inflammatory and neuroprotective agents

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Synthesis and biological evaluation of novel pyrazolyl-2,4-thiazolidinediones as anti-inflammatory and neuroprotective agents. / Youssef, Amal M; White, M Sydney; Villanueva, Erika B; El-Ashmawy, Ibrahim M; Klegeris, Andis.

In: Bioorganic & Medicinal Chemistry, Vol. 18, No. 5, 01.03.2010, p. 2019-28.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Youssef, AM, White, MS, Villanueva, EB, El-Ashmawy, IM & Klegeris, A 2010, 'Synthesis and biological evaluation of novel pyrazolyl-2,4-thiazolidinediones as anti-inflammatory and neuroprotective agents', Bioorganic & Medicinal Chemistry, vol. 18, no. 5, pp. 2019-28. https://doi.org/10.1016/j.bmc.2010.01.021

APA

Youssef, A. M., White, M. S., Villanueva, E. B., El-Ashmawy, I. M., & Klegeris, A. (2010). Synthesis and biological evaluation of novel pyrazolyl-2,4-thiazolidinediones as anti-inflammatory and neuroprotective agents. Bioorganic & Medicinal Chemistry, 18(5), 2019-28. https://doi.org/10.1016/j.bmc.2010.01.021

Vancouver

Youssef AM, White MS, Villanueva EB, El-Ashmawy IM, Klegeris A. Synthesis and biological evaluation of novel pyrazolyl-2,4-thiazolidinediones as anti-inflammatory and neuroprotective agents. Bioorganic & Medicinal Chemistry. 2010 Mar 1;18(5):2019-28. https://doi.org/10.1016/j.bmc.2010.01.021

Author

Youssef, Amal M ; White, M Sydney ; Villanueva, Erika B ; El-Ashmawy, Ibrahim M ; Klegeris, Andis. / Synthesis and biological evaluation of novel pyrazolyl-2,4-thiazolidinediones as anti-inflammatory and neuroprotective agents. In: Bioorganic & Medicinal Chemistry. 2010 ; Vol. 18, No. 5. pp. 2019-28.

Bibtex

@article{978bfe8967574ae1b42e68012735c032,
title = "Synthesis and biological evaluation of novel pyrazolyl-2,4-thiazolidinediones as anti-inflammatory and neuroprotective agents",
abstract = "Novel pyrazolyl-2,4-thiazolidinediones were prepared via the reaction of appropriate pyrazolecarboxaldehydes with 2,4-thiazolidinediones and substituted benzyl-2,4-thiazolidinediones. The resultant compounds were first evaluated for their anti-inflammatory and neuroprotective properties in vitro. The active compounds were further studied in vivo by using the formalin-induced paw edema and the turpentine oil-induced granuloma pouch bioassays. We identified four novel compounds that showed protective effects in vitro at non-toxic concentrations, and were also effective in the animal models of acute and sub-acute inflammation.",
keywords = "Animals, Anti-Inflammatory Agents/chemical synthesis, Cell Line, Tumor, Cyclooxygenase 1/metabolism, Cyclooxygenase 2/metabolism, Edema/chemically induced, Granuloma/chemically induced, HL-60 Cells, Humans, Neuroprotective Agents/chemical synthesis, Rats, Thiazolidinediones/chemical synthesis",
author = "Youssef, {Amal M} and White, {M Sydney} and Villanueva, {Erika B} and El-Ashmawy, {Ibrahim M} and Andis Klegeris",
note = "Copyright 2010 Elsevier Ltd. All rights reserved.",
year = "2010",
month = mar,
day = "1",
doi = "10.1016/j.bmc.2010.01.021",
language = "English",
volume = "18",
pages = "2019--28",
journal = "Bioorganic & Medicinal Chemistry",
issn = "0968-0896",
publisher = "Pergamon Press",
number = "5",

}

RIS

TY - JOUR

T1 - Synthesis and biological evaluation of novel pyrazolyl-2,4-thiazolidinediones as anti-inflammatory and neuroprotective agents

AU - Youssef, Amal M

AU - White, M Sydney

AU - Villanueva, Erika B

AU - El-Ashmawy, Ibrahim M

AU - Klegeris, Andis

N1 - Copyright 2010 Elsevier Ltd. All rights reserved.

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Novel pyrazolyl-2,4-thiazolidinediones were prepared via the reaction of appropriate pyrazolecarboxaldehydes with 2,4-thiazolidinediones and substituted benzyl-2,4-thiazolidinediones. The resultant compounds were first evaluated for their anti-inflammatory and neuroprotective properties in vitro. The active compounds were further studied in vivo by using the formalin-induced paw edema and the turpentine oil-induced granuloma pouch bioassays. We identified four novel compounds that showed protective effects in vitro at non-toxic concentrations, and were also effective in the animal models of acute and sub-acute inflammation.

AB - Novel pyrazolyl-2,4-thiazolidinediones were prepared via the reaction of appropriate pyrazolecarboxaldehydes with 2,4-thiazolidinediones and substituted benzyl-2,4-thiazolidinediones. The resultant compounds were first evaluated for their anti-inflammatory and neuroprotective properties in vitro. The active compounds were further studied in vivo by using the formalin-induced paw edema and the turpentine oil-induced granuloma pouch bioassays. We identified four novel compounds that showed protective effects in vitro at non-toxic concentrations, and were also effective in the animal models of acute and sub-acute inflammation.

KW - Animals

KW - Anti-Inflammatory Agents/chemical synthesis

KW - Cell Line, Tumor

KW - Cyclooxygenase 1/metabolism

KW - Cyclooxygenase 2/metabolism

KW - Edema/chemically induced

KW - Granuloma/chemically induced

KW - HL-60 Cells

KW - Humans

KW - Neuroprotective Agents/chemical synthesis

KW - Rats

KW - Thiazolidinediones/chemical synthesis

U2 - 10.1016/j.bmc.2010.01.021

DO - 10.1016/j.bmc.2010.01.021

M3 - Journal article

C2 - 20138770

VL - 18

SP - 2019

EP - 2028

JO - Bioorganic & Medicinal Chemistry

JF - Bioorganic & Medicinal Chemistry

SN - 0968-0896

IS - 5

ER -

ID: 236610080