Synthesis and nicotinic receptor activity of a hydroxylated tropane
Research output: Contribution to journal › Journal article › Research › peer-review
(+/-)-3alpha-hydroxy homoepibatidine 4 has been synthesized from the alkaloid scopolamine 5 and its properties as a nicotinic agonist assessed. While still binding strongly, the compound showed reduced agonist potency for the alpha(4)beta(2) nAChR compared with the parent compound epibatidine 1. Compound 4 also displayed generally similar binding and selectivity profiles at alpha(4)beta(2), alpha(2)beta(4), alpha(3)beta(4), and alpha(4)beta(4) nAChR subtypes to those for nicotine.
| Original language | English |
|---|---|
| Journal | Bioorganic & Medicinal Chemistry Letters |
| Volume | 14 |
| Issue number | 1 |
| Pages (from-to) | 271-3 |
| Number of pages | 3 |
| ISSN | 0960-894X |
| Publication status | Published - 2004 |
- Animals, Humans, Hydroxylation, Nicotinic Agonists, Protein Binding, Rats, Receptors, Nicotinic, Tropanes
Research areas
ID: 38485070