Targeting of microRNAs for therapeutics
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Targeting of microRNAs for therapeutics. / Stenvang, Jan; Lindow, Morten; Kauppinen, Sakari.
In: Biochemical Society Transactions, Vol. 36, No. Pt 6, 2008, p. 1197-200.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Targeting of microRNAs for therapeutics
AU - Stenvang, Jan
AU - Lindow, Morten
AU - Kauppinen, Sakari
N1 - Keywords: Animals; Disease; Humans; Mice; MicroRNAs; Oligonucleotides; Primates
PY - 2008
Y1 - 2008
N2 - miRNAs (microRNAs) comprise a class of small endogenous non-coding RNAs that post-transcriptionally repress gene expression by base-pairing with their target mRNAs. Recent evidence has shown that miRNAs play important roles in a wide variety of human diseases, such as viral infections, cancer and cardiovascular diseases, and thus miRNAs have rapidly emerged as potential targets for therapeutics. LNAs (locked nucleic acids) comprise a class of bicyclic conformational analogues of RNA, which exhibit high binding affinity to complementary RNA molecules and high stability in blood and tissues in vivo. Recent reports on LNA-mediated miRNA silencing in rodents and primates support the potential of LNA-modified oligonucleotides in studying miRNA functions in vivo and in the future development of miRNA-based therapeutics.
AB - miRNAs (microRNAs) comprise a class of small endogenous non-coding RNAs that post-transcriptionally repress gene expression by base-pairing with their target mRNAs. Recent evidence has shown that miRNAs play important roles in a wide variety of human diseases, such as viral infections, cancer and cardiovascular diseases, and thus miRNAs have rapidly emerged as potential targets for therapeutics. LNAs (locked nucleic acids) comprise a class of bicyclic conformational analogues of RNA, which exhibit high binding affinity to complementary RNA molecules and high stability in blood and tissues in vivo. Recent reports on LNA-mediated miRNA silencing in rodents and primates support the potential of LNA-modified oligonucleotides in studying miRNA functions in vivo and in the future development of miRNA-based therapeutics.
U2 - 10.1042/BST0361197
DO - 10.1042/BST0361197
M3 - Journal article
C2 - 19021524
VL - 36
SP - 1197
EP - 1200
JO - Biochemical Society Transactions
JF - Biochemical Society Transactions
SN - 0300-5127
IS - Pt 6
ER -
ID: 10826288