The antidepressant sertraline prevents the behavioral and EEG changes induced in two animal models of seizures

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The antidepressant sertraline prevents the behavioral and EEG changes induced in two animal models of seizures. / Sitges, María; Aldana, Blanca I.; Gómez, Carlos D.; Nekrassov, Vladimir.

In: Epilepsy and Behavior, Vol. 25, No. 4, 12.2012, p. 511-516.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sitges, M, Aldana, BI, Gómez, CD & Nekrassov, V 2012, 'The antidepressant sertraline prevents the behavioral and EEG changes induced in two animal models of seizures', Epilepsy and Behavior, vol. 25, no. 4, pp. 511-516. https://doi.org/10.1016/j.yebeh.2012.09.005

APA

Sitges, M., Aldana, B. I., Gómez, C. D., & Nekrassov, V. (2012). The antidepressant sertraline prevents the behavioral and EEG changes induced in two animal models of seizures. Epilepsy and Behavior, 25(4), 511-516. https://doi.org/10.1016/j.yebeh.2012.09.005

Vancouver

Sitges M, Aldana BI, Gómez CD, Nekrassov V. The antidepressant sertraline prevents the behavioral and EEG changes induced in two animal models of seizures. Epilepsy and Behavior. 2012 Dec;25(4):511-516. https://doi.org/10.1016/j.yebeh.2012.09.005

Author

Sitges, María ; Aldana, Blanca I. ; Gómez, Carlos D. ; Nekrassov, Vladimir. / The antidepressant sertraline prevents the behavioral and EEG changes induced in two animal models of seizures. In: Epilepsy and Behavior. 2012 ; Vol. 25, No. 4. pp. 511-516.

Bibtex

@article{6806f16db236468dac065439697e225d,
title = "The antidepressant sertraline prevents the behavioral and EEG changes induced in two animal models of seizures",
abstract = "In order to investigate a potential anticonvulsive action of sertraline (i.p.), its effects on seizures, EEG epileptiform activity and EEG amplitude increases induced by two convulsive agents were evaluated and compared with the effects of carbamazepine. Around 20. min following 4-aminopyridine (4-AP, 2.5. mg/kg, i.p.), tonic-clonic seizures and epileptiform activity were observed in control animals. A single sertraline pre-injection of 2.5. mg/kg, but not of 0.75. mg/kg, prevented these changes to 4-AP. Repeated daily administration of 0.75. mg/kg for one week, however, effectively inhibited the changes induced by 4-AP. The first generalized tonic-clonic seizure and EEG changes in response to pentylenetetrazole (PTZ, 50. mg/kg, i.p.) were observed near the first minute in control animals. Single sertraline doses above 5. mg/kg prevented the PTZ-induced changes. Moreover, a single carbamazepine dose of 25. mg/kg (i.p.), but not of 15. mg/kg, prevented the changes induced by the above convulsive agents. An anti-seizure action of the antidepressant sertraline is strongly suggested by these findings.",
keywords = "4-aminopyridine, Carbamazepine, Depression in epilepsy, Pentylenetetrazole",
author = "Mar{\'i}a Sitges and Aldana, {Blanca I.} and G{\'o}mez, {Carlos D.} and Vladimir Nekrassov",
year = "2012",
month = dec,
doi = "10.1016/j.yebeh.2012.09.005",
language = "English",
volume = "25",
pages = "511--516",
journal = "Epilepsy & Behavior",
issn = "1525-5050",
publisher = "Academic Press",
number = "4",

}

RIS

TY - JOUR

T1 - The antidepressant sertraline prevents the behavioral and EEG changes induced in two animal models of seizures

AU - Sitges, María

AU - Aldana, Blanca I.

AU - Gómez, Carlos D.

AU - Nekrassov, Vladimir

PY - 2012/12

Y1 - 2012/12

N2 - In order to investigate a potential anticonvulsive action of sertraline (i.p.), its effects on seizures, EEG epileptiform activity and EEG amplitude increases induced by two convulsive agents were evaluated and compared with the effects of carbamazepine. Around 20. min following 4-aminopyridine (4-AP, 2.5. mg/kg, i.p.), tonic-clonic seizures and epileptiform activity were observed in control animals. A single sertraline pre-injection of 2.5. mg/kg, but not of 0.75. mg/kg, prevented these changes to 4-AP. Repeated daily administration of 0.75. mg/kg for one week, however, effectively inhibited the changes induced by 4-AP. The first generalized tonic-clonic seizure and EEG changes in response to pentylenetetrazole (PTZ, 50. mg/kg, i.p.) were observed near the first minute in control animals. Single sertraline doses above 5. mg/kg prevented the PTZ-induced changes. Moreover, a single carbamazepine dose of 25. mg/kg (i.p.), but not of 15. mg/kg, prevented the changes induced by the above convulsive agents. An anti-seizure action of the antidepressant sertraline is strongly suggested by these findings.

AB - In order to investigate a potential anticonvulsive action of sertraline (i.p.), its effects on seizures, EEG epileptiform activity and EEG amplitude increases induced by two convulsive agents were evaluated and compared with the effects of carbamazepine. Around 20. min following 4-aminopyridine (4-AP, 2.5. mg/kg, i.p.), tonic-clonic seizures and epileptiform activity were observed in control animals. A single sertraline pre-injection of 2.5. mg/kg, but not of 0.75. mg/kg, prevented these changes to 4-AP. Repeated daily administration of 0.75. mg/kg for one week, however, effectively inhibited the changes induced by 4-AP. The first generalized tonic-clonic seizure and EEG changes in response to pentylenetetrazole (PTZ, 50. mg/kg, i.p.) were observed near the first minute in control animals. Single sertraline doses above 5. mg/kg prevented the PTZ-induced changes. Moreover, a single carbamazepine dose of 25. mg/kg (i.p.), but not of 15. mg/kg, prevented the changes induced by the above convulsive agents. An anti-seizure action of the antidepressant sertraline is strongly suggested by these findings.

KW - 4-aminopyridine

KW - Carbamazepine

KW - Depression in epilepsy

KW - Pentylenetetrazole

UR - http://www.scopus.com/inward/record.url?scp=84871831548&partnerID=8YFLogxK

U2 - 10.1016/j.yebeh.2012.09.005

DO - 10.1016/j.yebeh.2012.09.005

M3 - Journal article

C2 - 23153716

AN - SCOPUS:84871831548

VL - 25

SP - 511

EP - 516

JO - Epilepsy & Behavior

JF - Epilepsy & Behavior

SN - 1525-5050

IS - 4

ER -

ID: 260187964