TY - JOUR

T1 - The concise guide to pharmacology 2021/22

T2 - Ion channels

AU - Alexander, Stephen Ph

AU - Mathie, Alistair

AU - Peters, John A

AU - Veale, Emma L

AU - Striessnig, Jörg

AU - Kelly, Eamonn

AU - Armstrong, Jane F

AU - Faccenda, Elena

AU - Harding, Simon D

AU - Pawson, Adam J

AU - Southan, Christopher

AU - Davies, Jamie A

AU - Aldrich, Richard W

AU - Attali, Bernard

AU - Baggetta, Austin M

AU - Becirovic, Elvir

AU - Biel, Martin

AU - Bill, Roslyn M

AU - Catterall, William A

AU - Conner, Alex C

AU - Davies, Paul

AU - Delling, Markus

AU - Virgilio, Francesco Di

AU - Falzoni, Simonetta

AU - Fenske, Stefanie

AU - George, Chandy

AU - Goldstein, Steve A N

AU - Grissmer, Stephan

AU - Ha, Kotdaji

AU - Hammelmann, Verena

AU - Hanukoglu, Israel

AU - Jarvis, Mike

AU - Jensen, Anders A

AU - Kaczmarek, Leonard K

AU - Kellenberger, Stephan

AU - Kennedy, Charles

AU - King, Brian

AU - Kitchen, Philip

AU - Lynch, Joseph W

AU - Perez-Reyes, Edward

AU - Plant, Leigh D

AU - Rash, Lachlan

AU - Ren, Dejian

AU - Salman, Mootaz M

AU - Sivilotti, Lucia G

AU - Smart, Trevor G

AU - Snutch, Terrance P

AU - Tian, Jinbin

AU - Trimmer, James S

AU - Van den Eynde, Charlotte

AU - Vriens, Joris

AU - Wei, Aguan D

AU - Winn, Brenda T

AU - Wulff, Heike

AU - Xu, Haoxing

AU - Yue, Lixia

AU - Zhang, Xiaoli

AU - Zhu, Michael

N1 - Supplement: The Concise Guide to PHARMACOLOGY 2021/22. This issue was published by Wiley with financial contributions from the British Pharmacological Society, the International Union of Basic and Clinical Pharmacology and the University of Edinburgh, who host the guidetopharmacology.org website.

PY - 2021

Y1 - 2021

N2 - The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at https://onlinelibrary.wiley.com/doi/bph.15539. Ion channels are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

AB - The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at https://onlinelibrary.wiley.com/doi/bph.15539. Ion channels are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

KW - Databases, Pharmaceutical

KW - Humans

KW - Ion Channels

KW - Knowledge Bases

KW - Ligands

KW - Pharmacology

KW - Receptors, G-Protein-Coupled

U2 - 10.1111/bph.15539

DO - 10.1111/bph.15539

M3 - Journal article

C2 - 34529831

VL - 178

SP - S157-S245

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

SN - 0007-1188

IS - Suppl. 1

ER -