Towards discovery-driven translational research in breast cancer
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Towards discovery-driven translational research in breast cancer. / Celis, Julio E.; Moreira, José M.A.; Gromova, Irina; Cabezon, Teresa; Ralfkiaer, Ulrik; Guldberg, Per; Thor Straten, Per; Mouridsen, Henning; Friis, Esbern; Holm, Dorte; Rank, Fritz; Gromov, Pavel.
In: FEBS Journal, Vol. 272, No. 1, 01.01.2005, p. 2-15.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Towards discovery-driven translational research in breast cancer
AU - Celis, Julio E.
AU - Moreira, José M.A.
AU - Gromova, Irina
AU - Cabezon, Teresa
AU - Ralfkiaer, Ulrik
AU - Guldberg, Per
AU - Thor Straten, Per
AU - Mouridsen, Henning
AU - Friis, Esbern
AU - Holm, Dorte
AU - Rank, Fritz
AU - Gromov, Pavel
PY - 2005/1/1
Y1 - 2005/1/1
N2 - Discovery-driven translational research in breast cancer is moving steadily from the study of cell lines to the analysis of clinically relevant samples that, together with the ever increasing number of novel and powerful technologies available within genomics, proteomics and functional genomics, promise to have a major impact on the way breast cancer will be diagnosed, treated and monitored in the future. Here we present a brief report on long-term ongoing strategies at the Danish Centre for Translational Breast Cancer Research to search for markers for early detection and targets for therapeutic intervention, to identify signalling pathways affected in individual tumours, as well as to integrate multiplatform 'omic' data sets collected from tissue samples obtained from individual patients. The ultimate goal of this initiative is to coalesce knowledge-based complementary procedures into a systems biology approach to fight breast cancer.
AB - Discovery-driven translational research in breast cancer is moving steadily from the study of cell lines to the analysis of clinically relevant samples that, together with the ever increasing number of novel and powerful technologies available within genomics, proteomics and functional genomics, promise to have a major impact on the way breast cancer will be diagnosed, treated and monitored in the future. Here we present a brief report on long-term ongoing strategies at the Danish Centre for Translational Breast Cancer Research to search for markers for early detection and targets for therapeutic intervention, to identify signalling pathways affected in individual tumours, as well as to integrate multiplatform 'omic' data sets collected from tissue samples obtained from individual patients. The ultimate goal of this initiative is to coalesce knowledge-based complementary procedures into a systems biology approach to fight breast cancer.
KW - Breast cancer
KW - Functional genomics
KW - Individualised medicine
KW - Proteomics
KW - Signaling pathways
KW - Systems biology
KW - Translational research
UR - http://www.scopus.com/inward/record.url?scp=19944430032&partnerID=8YFLogxK
U2 - 10.1111/j.1432-1033.2004.04418.x
DO - 10.1111/j.1432-1033.2004.04418.x
M3 - Review
C2 - 15634327
AN - SCOPUS:19944430032
VL - 272
SP - 2
EP - 15
JO - The F E B S Journal (Online)
JF - The F E B S Journal (Online)
SN - 1742-4658
IS - 1
ER -
ID: 221777355