Vitamin D levels and the risk of prostate cancer and prostate cancer mortality

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Vitamin D levels and the risk of prostate cancer and prostate cancer mortality. / Stroomberg, Hein Vincent; Vojdeman, Fie Juhl; Madsen, Christian Medom; Helgstrand, John Thomas; Schwarz, Peter; Heegaard, Anne-Marie; Olsen, Anja; Tjønneland, Anne; Struer Lind, Bent; Brasso, Klaus; Jorgensen, Henrik Lovendahl; Roder, Martin Andreas.

In: Acta Oncologica, Vol. 60, No. 3, 2021, p. 316-322.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Stroomberg, HV, Vojdeman, FJ, Madsen, CM, Helgstrand, JT, Schwarz, P, Heegaard, A-M, Olsen, A, Tjønneland, A, Struer Lind, B, Brasso, K, Jorgensen, HL & Roder, MA 2021, 'Vitamin D levels and the risk of prostate cancer and prostate cancer mortality', Acta Oncologica, vol. 60, no. 3, pp. 316-322. https://doi.org/10.1080/0284186X.2020.1837391

APA

Stroomberg, H. V., Vojdeman, F. J., Madsen, C. M., Helgstrand, J. T., Schwarz, P., Heegaard, A-M., Olsen, A., Tjønneland, A., Struer Lind, B., Brasso, K., Jorgensen, H. L., & Roder, M. A. (2021). Vitamin D levels and the risk of prostate cancer and prostate cancer mortality. Acta Oncologica, 60(3), 316-322. https://doi.org/10.1080/0284186X.2020.1837391

Vancouver

Stroomberg HV, Vojdeman FJ, Madsen CM, Helgstrand JT, Schwarz P, Heegaard A-M et al. Vitamin D levels and the risk of prostate cancer and prostate cancer mortality. Acta Oncologica. 2021;60(3):316-322. https://doi.org/10.1080/0284186X.2020.1837391

Author

Stroomberg, Hein Vincent ; Vojdeman, Fie Juhl ; Madsen, Christian Medom ; Helgstrand, John Thomas ; Schwarz, Peter ; Heegaard, Anne-Marie ; Olsen, Anja ; Tjønneland, Anne ; Struer Lind, Bent ; Brasso, Klaus ; Jorgensen, Henrik Lovendahl ; Roder, Martin Andreas. / Vitamin D levels and the risk of prostate cancer and prostate cancer mortality. In: Acta Oncologica. 2021 ; Vol. 60, No. 3. pp. 316-322.

Bibtex

@article{fb1392071c124ea298581c2179773a33,
title = "Vitamin D levels and the risk of prostate cancer and prostate cancer mortality",
abstract = "BackgroundVitamin D has a role in bone turnover and potentially bone-metastatic spread of prostate cancer (PCa). The aim of this observational study was to address the association between levels of serum vitamin D, diagnosis of PCa and subsequent mortality in men who underwent a biopsy of the prostate.MethodsAll men who underwent prostatic biopsy in the Danish PCa Registry (DaPCaR) and who had a serum vitamin D measurement during the period 2004 to 2010 (n = 4,065) were identified. Men were categorized by clinical cut-offs based on seasonally adjusted serum vitamin D levels in 75 nmol/L (high) serum vitamin D. Logistic regression model for association between vitamin D and risk of PCa diagnosis and multivariate survival analyses were applied.ResultsNo association between serum vitamin D and risk of PCa was found. Overall survival was lowest for serum vitamin D deficiency and a significantly higher PCa specific mortality (HR: 2.37, 95%CI: 1.45-3.90, p <.001) and other cause mortality (HR: 2.08, 95%CI: 1.33-3.24, p = .001) was found for PCa patients with serum vitamin D deficiency compared to serum vitamin D sufficiency.ConclusionNo association was found between serum vitamin D categories and risk of PCa in men who underwent biopsy of the prostate. Men with PCa and serum vitamin D deficiency had a higher overall and PCa specific mortality compared to men with a sufficient level of serum vitamin D.",
keywords = "Prostatic neoplasms, Vitamin D, mortality, epidemiology, risk, 25-HYDROXYVITAMIN D, SURVIVAL",
author = "Stroomberg, {Hein Vincent} and Vojdeman, {Fie Juhl} and Madsen, {Christian Medom} and Helgstrand, {John Thomas} and Peter Schwarz and Anne-Marie Heegaard and Anja Olsen and Anne Tj{\o}nneland and {Struer Lind}, Bent and Klaus Brasso and Jorgensen, {Henrik Lovendahl} and Roder, {Martin Andreas}",
year = "2021",
doi = "10.1080/0284186X.2020.1837391",
language = "English",
volume = "60",
pages = "316--322",
journal = "Acta Oncologica",
issn = "1100-1704",
publisher = "Taylor & Francis",
number = "3",

}

RIS

TY - JOUR

T1 - Vitamin D levels and the risk of prostate cancer and prostate cancer mortality

AU - Stroomberg, Hein Vincent

AU - Vojdeman, Fie Juhl

AU - Madsen, Christian Medom

AU - Helgstrand, John Thomas

AU - Schwarz, Peter

AU - Heegaard, Anne-Marie

AU - Olsen, Anja

AU - Tjønneland, Anne

AU - Struer Lind, Bent

AU - Brasso, Klaus

AU - Jorgensen, Henrik Lovendahl

AU - Roder, Martin Andreas

PY - 2021

Y1 - 2021

N2 - BackgroundVitamin D has a role in bone turnover and potentially bone-metastatic spread of prostate cancer (PCa). The aim of this observational study was to address the association between levels of serum vitamin D, diagnosis of PCa and subsequent mortality in men who underwent a biopsy of the prostate.MethodsAll men who underwent prostatic biopsy in the Danish PCa Registry (DaPCaR) and who had a serum vitamin D measurement during the period 2004 to 2010 (n = 4,065) were identified. Men were categorized by clinical cut-offs based on seasonally adjusted serum vitamin D levels in 75 nmol/L (high) serum vitamin D. Logistic regression model for association between vitamin D and risk of PCa diagnosis and multivariate survival analyses were applied.ResultsNo association between serum vitamin D and risk of PCa was found. Overall survival was lowest for serum vitamin D deficiency and a significantly higher PCa specific mortality (HR: 2.37, 95%CI: 1.45-3.90, p <.001) and other cause mortality (HR: 2.08, 95%CI: 1.33-3.24, p = .001) was found for PCa patients with serum vitamin D deficiency compared to serum vitamin D sufficiency.ConclusionNo association was found between serum vitamin D categories and risk of PCa in men who underwent biopsy of the prostate. Men with PCa and serum vitamin D deficiency had a higher overall and PCa specific mortality compared to men with a sufficient level of serum vitamin D.

AB - BackgroundVitamin D has a role in bone turnover and potentially bone-metastatic spread of prostate cancer (PCa). The aim of this observational study was to address the association between levels of serum vitamin D, diagnosis of PCa and subsequent mortality in men who underwent a biopsy of the prostate.MethodsAll men who underwent prostatic biopsy in the Danish PCa Registry (DaPCaR) and who had a serum vitamin D measurement during the period 2004 to 2010 (n = 4,065) were identified. Men were categorized by clinical cut-offs based on seasonally adjusted serum vitamin D levels in 75 nmol/L (high) serum vitamin D. Logistic regression model for association between vitamin D and risk of PCa diagnosis and multivariate survival analyses were applied.ResultsNo association between serum vitamin D and risk of PCa was found. Overall survival was lowest for serum vitamin D deficiency and a significantly higher PCa specific mortality (HR: 2.37, 95%CI: 1.45-3.90, p <.001) and other cause mortality (HR: 2.08, 95%CI: 1.33-3.24, p = .001) was found for PCa patients with serum vitamin D deficiency compared to serum vitamin D sufficiency.ConclusionNo association was found between serum vitamin D categories and risk of PCa in men who underwent biopsy of the prostate. Men with PCa and serum vitamin D deficiency had a higher overall and PCa specific mortality compared to men with a sufficient level of serum vitamin D.

KW - Prostatic neoplasms

KW - Vitamin D

KW - mortality

KW - epidemiology

KW - risk

KW - 25-HYDROXYVITAMIN D

KW - SURVIVAL

U2 - 10.1080/0284186X.2020.1837391

DO - 10.1080/0284186X.2020.1837391

M3 - Journal article

C2 - 33103532

VL - 60

SP - 316

EP - 322

JO - Acta Oncologica

JF - Acta Oncologica

SN - 1100-1704

IS - 3

ER -

ID: 251354303