Christian Adam Olsen
Professor
Biopharmaceuticals
Jagtvej 162
2100 København Ø
- Published
Metabolic control by sirtuins and other enzymes that sense NAD(+), NADH, or their ratio
Anderson, K. A., Madsen, A. S., Olsen, Christian Adam & Hirschey, M. D., Dec 2017, In: B B A - Reviews on Cancer. 1858, 12, p. 991-998 8 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion
Anderson, K. A., Huynh, F. K., Fisher-Wellman, K., Stuart, J. D., Peterson, B. S., Douros, J. D., Wagner, G. R., Thompson, J. W., Madsen, A. S., Green, M. F., Sivley, R. M., Ilkayeva, O. R., Stevens, R. D., Backos, D. S., Capra, J. A., Olsen, Christian Adam, Campbell, J. E., Muoio, D. M., Grimsrud, P. A. & Hirschey, M. D., 4 Apr 2017, In: Cell Metabolism. 25, 4, p. 838-855.e15Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Guanidino groups greatly enhance the action of antimicrobial peptidomimetics against bacterial cytoplasmic membranes
Andreev, K., Bianchi, C., Laursen, J. S., Citterio, L., Hein-Kristensen, L., Gram, L., Kuzmenko, I., Olsen, Christian Adam & Gidalevitz, D., 2014, In: B B A - Biomembranes. 1838, 10, p. 2492-502 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The agr inhibitors solonamide B and analogues alter immune responses to Staphylococccus aureus but do not exhibit adverse effects on immune cell functions
Baldry, M., Kitir, B., Frøkiær, Hanne, Christensen, S. B., Taverne, N., Meijerink, M., Franzyk, Henrik, Olsen, Christian Adam, Wells, J. M. & Ingmer, Hanne, 2016, In: P L o S One. 11, 1, 17 p., e0145618.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Aryl Fluorosulfate Based Inhibitors That Covalently Target the SIRT5 Lysine Deacylase**
Bolding, J. E., Martín-Gago, P., Rajabi, N., Gamon, Luke Francis, Hansen, T. N., Bartling, Christian Reinhard Otto, Strømgaard, Kristian, Davies, Michael J. & Olsen, Christian Adam, 2022, In: Angewandte Chemie - International Edition. 61, 47, 11 p., e202204565.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide-Activated Sirtuin 7**
Bolding, J. E., Nielsen, A. L., Jensen, Iben, Hansen, T. N., Ryberg, Line Abildgaard, Jameson, S. T., Harris, Pernille, Peters, G. H. J., Denu, J. M., Rogers, Joseph Matthew & Olsen, Christian Adam, 2023, In: Angewandte Chemie - International Edition. 62, 49, e202314597.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Photo Cross-Linking Probes Containing ϵ-N-Thioacyllysine and ϵ-N-Acyl-(δ-aza)lysine Residues
Bæk, M., Martín-Gago, P., Laursen, J. S., Madsen, J. L. H., Chakladar, S. & Olsen, Christian Adam, 23 Mar 2020, In: Chemistry - A European Journal. 26, 17, p. 3862-3869 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cross-Talk between Staphylococcus aureus and Other Staphylococcal Species via the agr Quorum Sensing System
Canovas de la Nuez, J., Baldry, M., Bojer, Martin Saxtorph, Andersen, P. S., Grzeskowiak, P. K., Stegger, M., Damborg, Peter Panduro, Olsen, Christian Adam & Ingmer, Hanne, 2016, In: Frontiers in Microbiology. 7, 1733.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Chemical Biology-Medicinal Chemistry Continuum: EFMC's Vision
Duca, M., Gillingham, D., Olsen, Christian Adam, Sbardella, G., Skaanderup, P. R., van der Stelt, M., Vauzeilles, B., Vazquez, O. & Auberson, Y. P., 2021, In: ChemBioChem. 22, 19, p. 2823-2825Research output: Contribution to journal › Editorial › Research › peer-review
- Published
Effects of Thionation and Fluorination on Cis-Trans Isomerization in Tertiary Amides: An Investigation of N-Alkylglycine (Peptoid) Rotamers
Engel-Andreasen, J., Wich, K., Laursen, J. S., Harris, P. & Olsen, Christian Adam, 4 Mar 2015, In: Journal of Organic Chemistry. 80, 11, p. 5415–5427 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Backbone-Fluorinated 1,2,3-Triazole-Containing Dipeptide Surrogates
Engel-Andreasen, J., Wellhöfer, I., Wich, K. & Olsen, Christian Adam, 16 Oct 2017, In: Journal of Organic Chemistry. 82, 21, p. 11613-11619Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cellular uptake and membrane-destabilising properties of a-peptide/ß-peptoid chimeras: lessons for the design of new cell-penetrating peptides
Foged, Camilla, Franzyk, Henrik, Bahrami, S., Frøkjær, Sven, Jaroszewski, J. W., Nielsen, Hanne Mørck & Olsen, Christian Adam, 2008, In: BBA General Subjects. 1778, 11, p. 2487-2495Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Scalable and Purification-Free Synthesis of a Myristoylated Fluorogenic Sirtuin Substrate
Galleano, I., Nielsen, J., Stahl Madsen, A. & Olsen, Christian Adam, 2017, In: SYNLETT: Accounts and Rapid Communications in Chemical Synthesis. 28, 16, p. 2169-2173Research output: Contribution to journal › Letter › Research › peer-review
- Published
A Continuous, Fluorogenic Sirtuin 2 Deacylase Assay: Substrate Screening and Inhibitor Evaluation
Galleano, I., Schiedel, M., Jung, M., Madsen, A. S. & Olsen, Christian Adam, 11 Feb 2016, In: Journal of Medicinal Chemistry. 59, 3, p. 1021-31 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
On-Resin Peptide Cyclization Using the 3-Amino-4-(Methylamino)Benzoic Acid MeDbz Linker
Gless, B. H. & Olsen, Christian Adam, 2022, Methods in Molecular Biology. Humana Press, p. 101-115 (Methods in Molecular Biology, Vol. 2371).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Rearrangement of Thiodepsipeptides by S → N Acyl Shift Delivers Homodetic Autoinducing Peptides
Gless, B. H., Bejder, Benjamin Svejdal, Monda, F., Bojer, Martin Saxtorph, Ingmer, Hanne & Olsen, Christian Adam, 2021, In: Journal of the American Chemical Society. 143, 28, p. 10514–10518Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Förster Resonance Energy Transfer Assay for Investigating the Reactivity of Thioesters in Biochemistry and Native Chemical Ligation
Gless, B. H., Schmied, S. H., Bejder, Benjamin Svejdal & Olsen, Christian Adam, 2023, In: JACS Au. 3, 5, p. 1443–1451Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Direct Peptide Cyclization and One-Pot Modification Using the MeDbz Linker
Gless, B. H. & Olsen, Christian Adam, 6 Aug 2018, In: Journal of Organic Chemistry. 83, 17, p. 10525-10534Research output: Contribution to journal › Letter › Research › peer-review
- Published
Structure-activity relationship study based on Autoinducing Peptide (AIP) from dog pathogen S. schleiferi
Gless, B. H., Peng, P., Pedersen, K. D., Gotfredsen, C. H., Ingmer, Hanne & Olsen, Christian Adam, 2017, In: Organic Letters. 19, 19, p. 5276–5279Research output: Contribution to journal › Letter › Research › peer-review
- Published
Identification of autoinducing thiodepsipeptides from staphylococci enabled by native chemical ligation
Gless, B. H., Bojer, Martin Saxtorph, Peng, P., Baldry, M., Ingmer, Hanne & Olsen, Christian Adam, 22 Apr 2019, In: Nature Chemistry. 11, p. 463–469Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and antiangiogenic activity of N-alkylated levamisole derivatives
Hansen, A. N., Bendiksen, C. D., Sylvest, L., Friis, T., Stærk, Dan, Jørgensen, Flemming Steen, Olsen, Christian Adam & Houen, G., 2012, In: P L o S One. 7, 9, 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Accepted/In press
Sulfur(VI) Fluoride Exchange Chemistry in Solid-Phase Synthesis of Compound Arrays: Discovery of Histone Deacetylase Inhibitors
Hansen, T. N., Danková, D., Bæk, M., Grlaš, L. & Olsen, Christian Adam, 2024, (Accepted/In press) In: JACS Au.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Contemporary Applications of Thioamides and Methods for their Synthesis
Hansen, T. N. & Olsen, Christian Adam, 2024, In: Chemistry: A European Journal. 30, 9, e202303770.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Probing the Bioactive Conformation of an Archetypal Natural Product HDAC Inhibitor with Conformationally Homogeneous Triazole-Modified Cyclic Tetrapeptides
Horne, W. S., Olsen, Christian Adam, Beierle, J. M., Montero, A. & Ghadiri, M. R., 2009, In: Angewandte Chemie International Edition. 48, 26, p. 4718-4724Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides That Restore Trafficking and Activity of Delta F508-CFTR
Hutt, D. M., Olsen, Christian Adam, Vickers, C. J., Herman, D., Chalfant, M. A., Montero, A., Leman, L. J., Burkle, R., Maryanoff, B. E., Balch, W. E. & Ghadiri, M. R., Sep 2011, In: ACS Medicinal Chemistry Letters. 2, 9, p. 703-707Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effects of conformational constraints and steric bulk in the amino acid moiety of philanthotoxins on AMPAR antagonism
Jørgensen, M., Olsen, Christian Adam, Mellor, I. R., Usherwood, P. N. R., Witt, M., Franzyk, Henrik & Jaroszewski, J. W., 2005, In: Journal of Medicinal Chemistry. 48, 1, p. 56-70 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chemical Editing of Macrocyclic Natural Products and Kinetic Profiling Reveal Slow, Tight-Binding Histone Deacetylase Inhibitors with Picomolar Affinities
Kitir, B., Maolanon, A. R., Ohm, R. G., Colaço, A. R., Fristrup, P., Madsen, A. S. & Olsen, Christian Adam, 26 Sep 2017, In: Biochemistry. 56, 38, p. 5134-5146 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cyclic tetrapeptide HDAC inhibitors as potential therapeutics for spinal muscular atrophy: Screening with iPSC-derived neuronal cells
Lai, J. I., Leman, L. J., Ku, S., Vickers, C. J., Olsen, Christian Adam, Montero, A., Ghadiri, M. R. & Gottesfeld, J. M., 2017, In: Bioorganic and Medicinal Chemistry Letters. 27, 15, p. 3289-3293 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Triangular prism-shaped β-peptoid helices as unique biomimetic scaffolds
Laursen, J. S., Harris, Pernille, Fristrup, P. & Olsen, Christian Adam, 2015, In: Nature Communications. 6, p. 1-10 10 p., 7013.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
β-Peptoid Foldamers at Last
Laursen, J. S., Engel-Andreasen, J. & Olsen, Christian Adam, 20 Oct 2015, In: Accounts of Chemical Research. 48, 10, p. 2696-704 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cis-Trans Amide Bond Rotamers in beta-Peptoids and Peptoids: Evaluation of Stereoelectronic Effects in Backbone and Side Chains
Laursen, J. S., Engel-Andreasen, J., Fristrup, P., Harris, Pernille & Olsen, Christian Adam, 20 Feb 2013, In: Journal of the American Chemical Society. 135, 7, p. 2835-2844Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Peptide Inhibitors of the α-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction
Lynagh, T., Kiontke, S., Meyhoff-Madsen, M., Gless, B. H., Johannesen, J., Kattelmann, S., Christiansen, A., Dufva, M., Laustsen, A. H., Devkota, K., Olsen, Christian Adam, Kuemmel, D., Pless, Stephan & Lohse, B., 2020, In: Journal of Medicinal Chemistry. 63, 22, p. 13709-13718 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Optoepigenetics: An acetylation photoswitch
Madsen, A. S. & Olsen, Christian Adam, May 2016, In: Nature Chemical Biology. 12, 5, p. 306-7 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Investigating the Sensitivity of NAD(+)-dependent Sirtuin Deacylation Activities to NADH
Madsen, A. S., Andersen, C., Daoud, M., Anderson, K. A., Laursen, J. S., Chakladar, S., Huynh, F. K., Colaco, A. R., Backos, D. S., Fristrup, P., Hirschey, M. D. & Olsen, Christian Adam, 25 Mar 2016, In: Journal of Biological Chemistry. 291, 13, p. 7128-7141 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Substrates for Efficient Fluorometric Screening Employing the NAD-Dependent Sirtuin 5 Lysine Deacylase (KDAC) Enzyme
Madsen, A. S. & Olsen, Christian Adam, 14 Jun 2012, In: Journal of Medicinal Chemistry. 55, 11, p. 5582-5590Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Effect of Various Zinc Binding Groups on Inhibition of Histone Deacetylases 1-11
Madsen, A. S., Kristensen, H. M. E., Lanz, A. G. & Olsen, Christian Adam, Mar 2014, In: ChemMedChem. 9, 3, p. 614-626 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A potent trifluoromethyl ketone histone deacetylase inhibitor exhibits class-dependent mechanism of action
Madsen, A. S. & Olsen, Christian Adam, 2016, In: MedChemComm. 7, p. 464-470 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Natural and Synthetic Macrocyclic Inhibitors of the Histone Deacetylase Enzymes
Maolanon, A., Kristensen, H., Leman, L., Ghadiri, R. & Olsen, Christian Adam, 2017, In: ChemBioChem. 18, 1, p. 5-49 45 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Innovative Strategies for Selective Inhibition of Histone Deacetylases
Maolanon, A. R., Madsen, A. S. & Olsen, Christian Adam, 21 Jul 2016, In: Cell Chemical Biology. 23, 7, p. 759-768 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Methyl effect in azumamides provides insight into histone deacetylase inhibition by macrocycles
Maolanon, A. R., Villadsen, J. S., Christensen, Niels Johan, Hoeck, C., Friis, T., Harris, P., Gotfredsen, C. H., Fristrup, P. & Olsen, Christian Adam, 2014, In: Journal of Medicinal Chemistry. 57, 22, p. 9644-9657 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Arylfluorosulfate-Based Electrophiles for Covalent Protein Labeling: A New Addition to the Arsenal
Martín-Gago, P. & Olsen, Christian Adam, 21 Jan 2019, In: Angewandte Chemie - International Edition. 58, 4, p. 957-966 10 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation
McDonnell, E., Crown, S. B., Fox, D. B., Kitir, B., Ilkayeva, O. R., Olsen, Christian Adam, Grimsrud, P. A. & Hirschey, M. D., 1 Nov 2016, In: Cell Reports. 17, 6, p. 1463-1472 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design, Synthesis, Biological Evaluation, and Structural Characterization of Potent Histone Deacetylase Inhibitors Based on Cyclic alpha/beta-Tetrapeptide Architectures
Montero, A., Beierle, J. M., Olsen, Christian Adam & Ghadiri, M. R., 4 Mar 2009, In: Journal of the American Chemical Society. 131, 8, p. 3033-3041Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High-throughput screening of histone deacetylases and determination of kinetic parameters using fluorogenic assays
Moreno Yruela, Carlos & Olsen, Christian Adam, 2021, In: STAR Protocols. 2, 1, 14 p., 100313.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Histone Deacetylase 11 Is an ε- N -Myristoyllysine Hydrolase
Moreno Yruela, Carlos, Galleano, I., Madsen, A. S. & Olsen, Christian Adam, 3 May 2018, In: Cell Chemical Biology. 25, 7, p. 849-856Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chiral Posttranslational Modification to Lysine ε-Amino Groups
Moreno Yruela, Carlos, Baek, M., Monda, F. & Olsen, Christian Adam, 2022, In: Accounts of Chemical Research. 55, 10, p. 1456-1466Research output: Contribution to journal › Review › Research › peer-review
- Published
Elucidating the Enzymatic Activity of HDAC11
Moreno Yruela, Carlos, Galleano, I., Madsen, A. S. & Olsen, Christian Adam, 19 Aug 2018.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Hydroxamic acid-modified peptide microarrays for profiling isozyme-selective interactions and inhibition of histone deacetylases
Moreno Yruela, Carlos, Bæk, M., Vrsanova, A., Schulte, C., Maric, H. M. & Olsen, Christian Adam, 4 Jan 2021, In: Nature Communications. 12, 1Research output: Contribution to journal › Journal article › Research › peer-review
- Published
- Published
Synthesis of Trifluoromethyl Ketone Containing Amino Acid Building Blocks for the Preparation of Peptide-Based Histone Deacetylase (HDAC) Inhibitors
Moreno Yruela, Carlos & Olsen, Christian Adam, 2018, In: Synthesis. 50, 20, p. 4037-4046Research output: Contribution to journal › Journal article › Research › peer-review
ID: 101364066
Most downloads
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2040
downloads
Synthesis and antiangiogenic activity of N-alkylated levamisole derivatives
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
390
downloads
Cross-Talk between Staphylococcus aureus and Other Staphylococcal Species via the agr Quorum Sensing System
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
359
downloads
The agr inhibitors solonamide B and analogues alter immune responses to Staphylococccus aureus but do not exhibit adverse effects on immune cell functions
Research output: Contribution to journal › Journal article › Research › peer-review
Published