Absorption and metabolism of the absorption enhancer didecanoylphosphatidylcholine in rabbit nasal epithelium in vivo
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The absorption enhancer, didecanoylphosphatidylcholine (DDPC), improves the nasal absorption of human growth hormone in rabbits. We elucidated the uptake and the metabolism of 1,2-di[1-C]decanoyl-L-3-phosphatidylcholine and 1,2-didecanoyl-L-3-phosphatidyl[N-methyl-H]choline in rabbit nasal mucosa in vivo. One minute after nasal application of DDPC, 4.4-7.5% of the applied dose was found absorbed into the mucosa. The retained radioactivity left the tissue in
Original language | English |
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Journal | Drug Metabolism and Disposition |
Volume | 25 |
Issue number | 9 |
Pages (from-to) | 1083-1088 |
Number of pages | 6 |
ISSN | 0090-9556 |
Publication status | Published - 1 Jan 1997 |
ID: 45562023