ALA-PDT exerts beneficial effects on chronic venous ulcers by inducing changes in inflammatory microenvironment, especially through increased TGF-beta release: A pilot clinical and translational study.

Research output: Contribution to journalJournal articleResearchpeer-review

  • Vieri Grandi
  • Stefano Bacci
  • Alessandro Corsi
  • Sessa, Maurizio
  • Elisa Puliti
  • Nicoletta Murciano
  • Francesca Scavone
  • Pietro Cappugi
  • Nicola Pimpinelli
A cohort of 19 patients affected by chronic venous ulcers was recruited from our centre. A 4-mm punch biopsy from wound bed was taken before application of ALA 20% gel and repeated one hour after the first PDT irradiation. We observed a significant and progressive reduction of wounds mean volumes right after three ALA-PDT sessions (once per week; 4479.9+/-345.5mm(3) vs 34599+/-190.3mm(3), p
Original languageEnglish
JournalPhotodiagnosis and Photodynamic Therapy
Volume21
Pages (from-to)252-256
Number of pages5
ISSN1572-1000
DOIs
Publication statusPublished - Mar 2018
Externally publishedYes

ID: 197731869