Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Standard

Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood. / Brekke, Eva; Morken, Tora Sund; Walls, Anne B; Waagepetersen, Helle; Schousboe, Arne; Sonnewald, Ursula.

The Glutamate/ GABA- Glutamine Cycle : Amino Acid Neurotransmitter Homeostasis. Vol. 13 Springer, 2016. p. 43-58 (Advances in Neurobiology, Vol. 13).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Harvard

Brekke, E, Morken, TS, Walls, AB, Waagepetersen, H, Schousboe, A & Sonnewald, U 2016, Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood. in The Glutamate/ GABA- Glutamine Cycle : Amino Acid Neurotransmitter Homeostasis. vol. 13, Springer, Advances in Neurobiology, vol. 13, pp. 43-58. https://doi.org/10.1007/978-3-319-45096-4_3

APA

Brekke, E., Morken, T. S., Walls, A. B., Waagepetersen, H., Schousboe, A., & Sonnewald, U. (2016). Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood. In The Glutamate/ GABA- Glutamine Cycle : Amino Acid Neurotransmitter Homeostasis (Vol. 13, pp. 43-58). Springer. Advances in Neurobiology Vol. 13 https://doi.org/10.1007/978-3-319-45096-4_3

Vancouver

Brekke E, Morken TS, Walls AB, Waagepetersen H, Schousboe A, Sonnewald U. Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood. In The Glutamate/ GABA- Glutamine Cycle : Amino Acid Neurotransmitter Homeostasis. Vol. 13. Springer. 2016. p. 43-58. (Advances in Neurobiology, Vol. 13). https://doi.org/10.1007/978-3-319-45096-4_3

Author

Brekke, Eva ; Morken, Tora Sund ; Walls, Anne B ; Waagepetersen, Helle ; Schousboe, Arne ; Sonnewald, Ursula. / Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood. The Glutamate/ GABA- Glutamine Cycle : Amino Acid Neurotransmitter Homeostasis. Vol. 13 Springer, 2016. pp. 43-58 (Advances in Neurobiology, Vol. 13).

Bibtex

@inbook{5a82ce80ec6a4dd0bccacaaced9de8a4,
title = "Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood",
abstract = "A central task of the tricarboxylic acid (TCA, Krebs, citric acid) cycle in brain is to provide precursors for biosynthesis of glutamate, GABA, aspartate and glutamine. Three of these amino acids are the partners in the intricate interaction between astrocytes and neurons and form the so-called glutamine-glutamate (GABA) cycle. The ketoacids α-ketoglutarate and oxaloacetate are removed from the cycle for this process. When something is removed from the TCA cycle it must be replaced to permit the continued function of this essential pathway, a process termed anaplerosis. This anaplerotic process in the brain is mainly carried out by pyruvate carboxylation performed by pyruvate carboxylase. The present book chapter gives an introduction and overview into this carboxylation and additionally anaplerosis mediated by propionyl-CoA carboxylase under physiological conditions in the adult and in the developing rodent brain. Furthermore, examples are given about pathological conditions in which anaplerosis is disturbed.",
author = "Eva Brekke and Morken, {Tora Sund} and Walls, {Anne B} and Helle Waagepetersen and Arne Schousboe and Ursula Sonnewald",
year = "2016",
doi = "10.1007/978-3-319-45096-4_3",
language = "English",
volume = "13",
series = "Advances in Neurobiology",
publisher = "Springer",
pages = "43--58",
booktitle = "The Glutamate/ GABA- Glutamine Cycle",
address = "Switzerland",

}

RIS

TY - CHAP

T1 - Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood

AU - Brekke, Eva

AU - Morken, Tora Sund

AU - Walls, Anne B

AU - Waagepetersen, Helle

AU - Schousboe, Arne

AU - Sonnewald, Ursula

PY - 2016

Y1 - 2016

N2 - A central task of the tricarboxylic acid (TCA, Krebs, citric acid) cycle in brain is to provide precursors for biosynthesis of glutamate, GABA, aspartate and glutamine. Three of these amino acids are the partners in the intricate interaction between astrocytes and neurons and form the so-called glutamine-glutamate (GABA) cycle. The ketoacids α-ketoglutarate and oxaloacetate are removed from the cycle for this process. When something is removed from the TCA cycle it must be replaced to permit the continued function of this essential pathway, a process termed anaplerosis. This anaplerotic process in the brain is mainly carried out by pyruvate carboxylation performed by pyruvate carboxylase. The present book chapter gives an introduction and overview into this carboxylation and additionally anaplerosis mediated by propionyl-CoA carboxylase under physiological conditions in the adult and in the developing rodent brain. Furthermore, examples are given about pathological conditions in which anaplerosis is disturbed.

AB - A central task of the tricarboxylic acid (TCA, Krebs, citric acid) cycle in brain is to provide precursors for biosynthesis of glutamate, GABA, aspartate and glutamine. Three of these amino acids are the partners in the intricate interaction between astrocytes and neurons and form the so-called glutamine-glutamate (GABA) cycle. The ketoacids α-ketoglutarate and oxaloacetate are removed from the cycle for this process. When something is removed from the TCA cycle it must be replaced to permit the continued function of this essential pathway, a process termed anaplerosis. This anaplerotic process in the brain is mainly carried out by pyruvate carboxylation performed by pyruvate carboxylase. The present book chapter gives an introduction and overview into this carboxylation and additionally anaplerosis mediated by propionyl-CoA carboxylase under physiological conditions in the adult and in the developing rodent brain. Furthermore, examples are given about pathological conditions in which anaplerosis is disturbed.

U2 - 10.1007/978-3-319-45096-4_3

DO - 10.1007/978-3-319-45096-4_3

M3 - Book chapter

C2 - 27885626

VL - 13

T3 - Advances in Neurobiology

SP - 43

EP - 58

BT - The Glutamate/ GABA- Glutamine Cycle

PB - Springer

ER -

ID: 170012053