Association Between Human Pain-Related Genotypes and Variability in Opioid Analgesia: An Updated Review

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Association Between Human Pain-Related Genotypes and Variability in Opioid Analgesia : An Updated Review. / Nielsen, Lecia M; Olesen, Anne Estrup; Branford, Ruth; Christrup, Lona Louring; Sato, Hiroe; Drewes, Asbjørn M.

In: Pain Practice, Vol. 15, No. 6, 2015, p. 580–594.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nielsen, LM, Olesen, AE, Branford, R, Christrup, LL, Sato, H & Drewes, AM 2015, 'Association Between Human Pain-Related Genotypes and Variability in Opioid Analgesia: An Updated Review', Pain Practice, vol. 15, no. 6, pp. 580–594. https://doi.org/10.1111/papr.12232

APA

Nielsen, L. M., Olesen, A. E., Branford, R., Christrup, L. L., Sato, H., & Drewes, A. M. (2015). Association Between Human Pain-Related Genotypes and Variability in Opioid Analgesia: An Updated Review. Pain Practice, 15(6), 580–594. https://doi.org/10.1111/papr.12232

Vancouver

Nielsen LM, Olesen AE, Branford R, Christrup LL, Sato H, Drewes AM. Association Between Human Pain-Related Genotypes and Variability in Opioid Analgesia: An Updated Review. Pain Practice. 2015;15(6):580–594. https://doi.org/10.1111/papr.12232

Author

Nielsen, Lecia M ; Olesen, Anne Estrup ; Branford, Ruth ; Christrup, Lona Louring ; Sato, Hiroe ; Drewes, Asbjørn M. / Association Between Human Pain-Related Genotypes and Variability in Opioid Analgesia : An Updated Review. In: Pain Practice. 2015 ; Vol. 15, No. 6. pp. 580–594.

Bibtex

@article{ac1f55a96e154094bdc2b879fc8ede0b,
title = "Association Between Human Pain-Related Genotypes and Variability in Opioid Analgesia: An Updated Review",
abstract = "On an individual level, there is a difference in the analgesic response to a given opioid. Various factors such as gender, age, and genetic variation can affect the analgesic response. The genetic variation can influence pharmacokinetics (eg drug transporters and drug-metabolizing enzymes) and/or pharmacodynamics (eg opioid receptor and catechol-O-methyltransferase enzymes). We present recent experimentally induced pain, postoperative pain, and cancer pain and chronic non-malignant pain conditions studies in humans, focusing on the association between genetic variation and analgesic response assessed as opioid consumption or changes in pain scores. Studies have shown promising results regarding pharmacogenetics as a diagnostic tool for predicting the individual response to a given opioid in the experimental settings; however, in the clinic, it is a more complicated task to accomplish.",
author = "Nielsen, {Lecia M} and Olesen, {Anne Estrup} and Ruth Branford and Christrup, {Lona Louring} and Hiroe Sato and Drewes, {Asbj{\o}rn M}",
note = "{\textcopyright} 2014 World Institute of Pain.",
year = "2015",
doi = "10.1111/papr.12232",
language = "English",
volume = "15",
pages = "580–594",
journal = "Pain Practice",
issn = "1530-7085",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS

TY - JOUR

T1 - Association Between Human Pain-Related Genotypes and Variability in Opioid Analgesia

T2 - An Updated Review

AU - Nielsen, Lecia M

AU - Olesen, Anne Estrup

AU - Branford, Ruth

AU - Christrup, Lona Louring

AU - Sato, Hiroe

AU - Drewes, Asbjørn M

N1 - © 2014 World Institute of Pain.

PY - 2015

Y1 - 2015

N2 - On an individual level, there is a difference in the analgesic response to a given opioid. Various factors such as gender, age, and genetic variation can affect the analgesic response. The genetic variation can influence pharmacokinetics (eg drug transporters and drug-metabolizing enzymes) and/or pharmacodynamics (eg opioid receptor and catechol-O-methyltransferase enzymes). We present recent experimentally induced pain, postoperative pain, and cancer pain and chronic non-malignant pain conditions studies in humans, focusing on the association between genetic variation and analgesic response assessed as opioid consumption or changes in pain scores. Studies have shown promising results regarding pharmacogenetics as a diagnostic tool for predicting the individual response to a given opioid in the experimental settings; however, in the clinic, it is a more complicated task to accomplish.

AB - On an individual level, there is a difference in the analgesic response to a given opioid. Various factors such as gender, age, and genetic variation can affect the analgesic response. The genetic variation can influence pharmacokinetics (eg drug transporters and drug-metabolizing enzymes) and/or pharmacodynamics (eg opioid receptor and catechol-O-methyltransferase enzymes). We present recent experimentally induced pain, postoperative pain, and cancer pain and chronic non-malignant pain conditions studies in humans, focusing on the association between genetic variation and analgesic response assessed as opioid consumption or changes in pain scores. Studies have shown promising results regarding pharmacogenetics as a diagnostic tool for predicting the individual response to a given opioid in the experimental settings; however, in the clinic, it is a more complicated task to accomplish.

U2 - 10.1111/papr.12232

DO - 10.1111/papr.12232

M3 - Journal article

C2 - 25201705

VL - 15

SP - 580

EP - 594

JO - Pain Practice

JF - Pain Practice

SN - 1530-7085

IS - 6

ER -

ID: 129173929