Does mutual compensation of the cognitive effects induced by pain and opioids exist? An experimental study
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Does mutual compensation of the cognitive effects induced by pain and opioids exist? An experimental study. / Kurita, Geana Paula; Malver, Lasse Paludan; Andresen, Trine; Polianskis, Romanas; Drewes, Asbjørn Mohr; Christrup, Lona Louring; Højsted, Jette; Sjøgren, Per.
In: Psychopharmacology, Vol. 232, No. 8, 2015, p. 1373-1381.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Does mutual compensation of the cognitive effects induced by pain and opioids exist?
T2 - An experimental study
AU - Kurita, Geana Paula
AU - Malver, Lasse Paludan
AU - Andresen, Trine
AU - Polianskis, Romanas
AU - Drewes, Asbjørn Mohr
AU - Christrup, Lona Louring
AU - Højsted, Jette
AU - Sjøgren, Per
PY - 2015
Y1 - 2015
N2 - RATIONALE: Studies have demonstrated that both pain and opioids have actions on the central nervous system that may interfere with cognitive function, but their effects have mainly been analysed separately and not as an integrated process.OBJECTIVE: The objective of this study is to test two hypotheses: (1) the analgesic effect of opioids improves cognitive function by decreasing pain, and (2) pain antagonizes cognitive effects of opioids.METHODS: Randomized, placebo-controlled, crossover study. Three experiments were conducted with 22 healthy males. Sustained attention, memory and motor function/attention/mental flexibility were evaluated by continuous reaction time (CRT), verbal fluency test (VFT) and trail making test-B (TMT-B), respectively. In the 1st experiment, the cognitive effects of experimental tonic pain of mild and moderate intensities produced by a computer-controlled pneumatic tourniquet cuff were assessed; in the 2nd, the effects of saline solution and remifentanil were assessed in the absence of pain; and in the 3rd experiment, the cognitive effects of moderate pain intensity relieved by remifentanil infusion were assessed followed by increasing pain to moderate intensity during a constant remifentanil infusion.RESULTS: The first two experiments demonstrated that pain and remifentanil impaired CRT. In the 3rd experiment, remifentanil infusion relieving pain significantly impaired CRT and further deterioration was noted following increasing pain intensity.CONCLUSION: Pain and remifentanil seemed to have additive deleterious cognitive effects. This study represents an initial step to enhance our basic understanding of some of the cognitive effects following a painful stimulus and an opioid infusion separately and combined in a sequence comparable to clinical settings.
AB - RATIONALE: Studies have demonstrated that both pain and opioids have actions on the central nervous system that may interfere with cognitive function, but their effects have mainly been analysed separately and not as an integrated process.OBJECTIVE: The objective of this study is to test two hypotheses: (1) the analgesic effect of opioids improves cognitive function by decreasing pain, and (2) pain antagonizes cognitive effects of opioids.METHODS: Randomized, placebo-controlled, crossover study. Three experiments were conducted with 22 healthy males. Sustained attention, memory and motor function/attention/mental flexibility were evaluated by continuous reaction time (CRT), verbal fluency test (VFT) and trail making test-B (TMT-B), respectively. In the 1st experiment, the cognitive effects of experimental tonic pain of mild and moderate intensities produced by a computer-controlled pneumatic tourniquet cuff were assessed; in the 2nd, the effects of saline solution and remifentanil were assessed in the absence of pain; and in the 3rd experiment, the cognitive effects of moderate pain intensity relieved by remifentanil infusion were assessed followed by increasing pain to moderate intensity during a constant remifentanil infusion.RESULTS: The first two experiments demonstrated that pain and remifentanil impaired CRT. In the 3rd experiment, remifentanil infusion relieving pain significantly impaired CRT and further deterioration was noted following increasing pain intensity.CONCLUSION: Pain and remifentanil seemed to have additive deleterious cognitive effects. This study represents an initial step to enhance our basic understanding of some of the cognitive effects following a painful stimulus and an opioid infusion separately and combined in a sequence comparable to clinical settings.
U2 - 10.1007/s00213-014-3768-y
DO - 10.1007/s00213-014-3768-y
M3 - Journal article
C2 - 25345731
VL - 232
SP - 1373
EP - 1381
JO - Psychopharmacology
JF - Psychopharmacology
SN - 0033-3158
IS - 8
ER -
ID: 126225989