Increased Antioxidant Capacity and Pro-Homeostatic Lipid Mediators in Ocular Hypertension-A Human Experimental Model
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Increased Antioxidant Capacity and Pro-Homeostatic Lipid Mediators in Ocular Hypertension-A Human Experimental Model. / Langbol, Mia; Saruhanian, Sarkis; Baskaran, Thisayini; Tiedemann, Daniel; Mouhammad, Zaynab A.; Toft-Kehler, Anne Katrine; Jun, Bokkyoo; Vohra, Rupali; Bazan, Nicolas G.; Kolko, Miriam.
In: Journal of Clinical Medicine, Vol. 9, No. 9, 2979, 2020.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Increased Antioxidant Capacity and Pro-Homeostatic Lipid Mediators in Ocular Hypertension-A Human Experimental Model
AU - Langbol, Mia
AU - Saruhanian, Sarkis
AU - Baskaran, Thisayini
AU - Tiedemann, Daniel
AU - Mouhammad, Zaynab A.
AU - Toft-Kehler, Anne Katrine
AU - Jun, Bokkyoo
AU - Vohra, Rupali
AU - Bazan, Nicolas G.
AU - Kolko, Miriam
PY - 2020
Y1 - 2020
N2 - The main risk factor for primary open-angle glaucoma (POAG) is increased intraocular pressure (IOP). It is of interest that about half of the patients have an IOP within the normal range (normal-tension glaucoma, NTG). Additionally, there is a group of patients with a high IOP but no glaucomatous neurodegeneration (ocular hypertension, OHT). Therefore, risk factors other than IOP are involved in the pathogenesis of glaucoma. Since the retina has a very high oxygen-demand, decreased autoregulation and a fluctuating oxygen supply to the retina have been linked to glaucomatous neurodegeneration. To assess the significance of these mechanisms, we have utilized a human experimental model, in which we stress participants with a fluctuating oxygen supply. Levels of oxidative stress molecules, antioxidants, and lipid mediators were measured in the plasma. Patients with NTG, OHT, and control subjects were found to have similar levels of oxidative stress markers. In contrast, patients with OHT had a higher level of total antioxidant capacity (TAC) and pro-homeostatic lipid mediators. Thus, we suggest that OHT patients manage fluctuating oxygen levels more efficiently and, thus, are less susceptible to glaucomatous neurodegenerations, due to enhanced systemic antioxidant protection.
AB - The main risk factor for primary open-angle glaucoma (POAG) is increased intraocular pressure (IOP). It is of interest that about half of the patients have an IOP within the normal range (normal-tension glaucoma, NTG). Additionally, there is a group of patients with a high IOP but no glaucomatous neurodegeneration (ocular hypertension, OHT). Therefore, risk factors other than IOP are involved in the pathogenesis of glaucoma. Since the retina has a very high oxygen-demand, decreased autoregulation and a fluctuating oxygen supply to the retina have been linked to glaucomatous neurodegeneration. To assess the significance of these mechanisms, we have utilized a human experimental model, in which we stress participants with a fluctuating oxygen supply. Levels of oxidative stress molecules, antioxidants, and lipid mediators were measured in the plasma. Patients with NTG, OHT, and control subjects were found to have similar levels of oxidative stress markers. In contrast, patients with OHT had a higher level of total antioxidant capacity (TAC) and pro-homeostatic lipid mediators. Thus, we suggest that OHT patients manage fluctuating oxygen levels more efficiently and, thus, are less susceptible to glaucomatous neurodegenerations, due to enhanced systemic antioxidant protection.
KW - antioxidant capacity
KW - oxidative stress
KW - normal-tension glaucoma
KW - ocular hypertension
KW - hypoxia
KW - lipidomics
KW - pro-homeostatic lipid mediators
KW - hydroxyeicosatetraenoic acids
KW - hydroxydocosahexaenoic acids
KW - OXIDATIVE STRESS MARKERS
KW - TRABECULAR MESHWORK CELLS
KW - NORMAL-TENSION GLAUCOMA
KW - OPEN-ANGLE GLAUCOMA
KW - RED-BLOOD-CELLS
KW - AQUEOUS-HUMOR
KW - VENTILATORY RESPONSE
KW - DNA-DAMAGE
KW - HYPOXIA
KW - ASSOCIATION
U2 - 10.3390/jcm9092979
DO - 10.3390/jcm9092979
M3 - Journal article
C2 - 32942740
VL - 9
JO - Journal of Clinical Medicine
JF - Journal of Clinical Medicine
SN - 2077-0383
IS - 9
M1 - 2979
ER -
ID: 254731760