Molecular pharmacology and therapeutic prospects of metabotropic glutamate receptor allosteric modulators
Research output: Contribution to journal › Journal article › Research › peer-review
The metabotropic glutamate receptors (mGluR) consist of a family of eight G-protein-coupled receptors that differ in their function, distribution and physiological roles within the central nervous system. In recent years substantial efforts have been made towards developing selective agonists and antagonists which have proven useful for elucidating their potential as novel targets for the treatment of psychiatric and neurological diseases. In the present review we will provide an update of the recent developments of functional allosteric modulators of the mGluR family and explore their therapeutic potential for anxiety/depression, schizophrenia, epilepsy/stroke, pain and Alzheimer's, Parkinson's and Huntington's diseases.
Original language | English |
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Journal | Basic and Clinical Pharmacology and Toxicology |
Volume | 97 |
Issue number | 4 |
Pages (from-to) | 202-213 |
Number of pages | 12 |
ISSN | 1742-7835 |
DOIs | |
Publication status | Published - 1 Oct 2005 |
ID: 221756457