Offset Analgesia and The Impact of Treatment with Oxycodone and Venlafaxine: A Placebo-Controlled, Randomized Trial in Healthy Volunteers
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Offset Analgesia and The Impact of Treatment with Oxycodone and Venlafaxine : A Placebo-Controlled, Randomized Trial in Healthy Volunteers. / Olesen, Anne E.; Nissen, Thomas D.; Nilsson, Matias; Lelic, Dina; Brock, Christina; Christrup, Lona L.; Drewes, Asbjørn M.
In: Basic and Clinical Pharmacology and Toxicology, Vol. 123, No. 6, 2018, p. 727-731.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Offset Analgesia and The Impact of Treatment with Oxycodone and Venlafaxine
T2 - A Placebo-Controlled, Randomized Trial in Healthy Volunteers
AU - Olesen, Anne E.
AU - Nissen, Thomas D.
AU - Nilsson, Matias
AU - Lelic, Dina
AU - Brock, Christina
AU - Christrup, Lona L.
AU - Drewes, Asbjørn M.
PY - 2018
Y1 - 2018
N2 - Offset analgesia (OA) is a pain-modulating mechanism described as a disproportionately large decrease in pain intensity evoked by a discrete decrease in stimulus temperature. The role of the opioidergic, serotonergic and noradrenergic systems on OA remains unclear. The aim of this study was to evaluate whether OA is modulated by an opioid (oxycodone) and a serotonin and noradrenaline reuptake inhibitor (venlafaxine) in terms of psychophysical assessments. In this randomized, double-blinded, placebo-controlled cross-over study, 20 healthy male participants (mean age: 24.6 ± 2.5 years) received 10 mg oxycodone, 37.5 mg venlafaxine or placebo twice daily for 5 days in three periods. OA was induced by noxious thermal stimulation on the forearm at baseline and last day of treatment. A control session of constant stimulus intensity was included for comparison. OA magnitude was unaffected by oxycodone and venlafaxine (p = 0.20 and p = 0.90, respectively). Oxycodone affected the control paradigm where a decreased rating of pain intensity was observed compared to placebo (p = 0.001). OA could not be modulated by oxycodone or venlafaxine and may be a robust phenomenon in healthy volunteers and not suitable for exploring pharmacological mechanisms of analgesia in human beings.
AB - Offset analgesia (OA) is a pain-modulating mechanism described as a disproportionately large decrease in pain intensity evoked by a discrete decrease in stimulus temperature. The role of the opioidergic, serotonergic and noradrenergic systems on OA remains unclear. The aim of this study was to evaluate whether OA is modulated by an opioid (oxycodone) and a serotonin and noradrenaline reuptake inhibitor (venlafaxine) in terms of psychophysical assessments. In this randomized, double-blinded, placebo-controlled cross-over study, 20 healthy male participants (mean age: 24.6 ± 2.5 years) received 10 mg oxycodone, 37.5 mg venlafaxine or placebo twice daily for 5 days in three periods. OA was induced by noxious thermal stimulation on the forearm at baseline and last day of treatment. A control session of constant stimulus intensity was included for comparison. OA magnitude was unaffected by oxycodone and venlafaxine (p = 0.20 and p = 0.90, respectively). Oxycodone affected the control paradigm where a decreased rating of pain intensity was observed compared to placebo (p = 0.001). OA could not be modulated by oxycodone or venlafaxine and may be a robust phenomenon in healthy volunteers and not suitable for exploring pharmacological mechanisms of analgesia in human beings.
U2 - 10.1111/bcpt.13078
DO - 10.1111/bcpt.13078
M3 - Journal article
C2 - 29938898
AN - SCOPUS:85056149681
VL - 123
SP - 727
EP - 731
JO - Basic and Clinical Pharmacology and Toxicology
JF - Basic and Clinical Pharmacology and Toxicology
SN - 1742-7835
IS - 6
ER -
ID: 221753189