Pain, sedation and morphine metabolism in cancer patients during long-term treatment with sustained-release morphine
Research output: Contribution to journal › Journal article › Research › peer-review
Morphine-6-glucuronide (M-6-G) and morphine-3-glucuronide (M-3-G) are the two most important metabolites of morphine. Both are pharmacologically active, however, with different effects. M-6-G has been demonstrated capable of inducing anti-nociception and sedation, and M-3-G may induce behavioural excitation and possibly antagonise anti-nociception. Their impact on pharmacodynamics in patients in long-term treatment with oral morphine remains to be settled.
Original language | English |
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Journal | Palliative Medicine |
Volume | 16 |
Issue number | 2 |
Pages (from-to) | 107-14 |
Number of pages | 8 |
ISSN | 0269-2163 |
Publication status | Published - Mar 2002 |
Externally published | Yes |
- Adult, Aged, Analgesics, Opioid, Delayed-Action Preparations, Female, Humans, Male, Middle Aged, Morphine, Morphine Derivatives, Neoplasms, Pain
Research areas
ID: 46099227