Pharmacological consequences of long-term morphine treatment in patients with cancer and chronic non-malignant pain
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Pharmacological consequences of long-term morphine treatment in patients with cancer and chronic non-malignant pain. / Andersen, Gertrud; Sjøgren, Per; Hansen, Steen Honoré; Jensen, Niels-Henrik; Christrup, Lona Louring.
In: European Journal of Pain, Vol. 8, No. 3, 06.2004, p. 263-71.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Pharmacological consequences of long-term morphine treatment in patients with cancer and chronic non-malignant pain
AU - Andersen, Gertrud
AU - Sjøgren, Per
AU - Hansen, Steen Honoré
AU - Jensen, Niels-Henrik
AU - Christrup, Lona Louring
PY - 2004/6
Y1 - 2004/6
N2 - In patients with pain of malignant origin morphine may be administered in high and often increasing doses during extended periods of time. In patients with chronic pain of non-malignant origin morphine may be an important remedy, and in these cases the goal is to keep the morphine dose stable. The pharmacokinetic as well as the pharmacodynamic consequences of long-term morphine treatment with special reference to the two most important metabolites of morphine morphine-6-glucuronide (M-6-G) and morphine-3-glucuronide (M-3-G) remain to be settled.
AB - In patients with pain of malignant origin morphine may be administered in high and often increasing doses during extended periods of time. In patients with chronic pain of non-malignant origin morphine may be an important remedy, and in these cases the goal is to keep the morphine dose stable. The pharmacokinetic as well as the pharmacodynamic consequences of long-term morphine treatment with special reference to the two most important metabolites of morphine morphine-6-glucuronide (M-6-G) and morphine-3-glucuronide (M-3-G) remain to be settled.
KW - Adult
KW - Aged
KW - Analgesics, Opioid
KW - Chronic Disease
KW - Dose-Response Relationship, Drug
KW - Drug Administration Routes
KW - Drug Administration Schedule
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Morphine
KW - Morphine Derivatives
KW - Neoplasms
KW - Pain
KW - Pain Measurement
KW - Salivary Glands
KW - Xerostomia
U2 - 10.1016/j.ejpain.2003.09.003
DO - 10.1016/j.ejpain.2003.09.003
M3 - Journal article
C2 - 15109977
VL - 8
SP - 263
EP - 271
JO - European Journal of Pain
JF - European Journal of Pain
SN - 1090-3801
IS - 3
ER -
ID: 46098448