Recommended use of morphine in neonates, infants and children based on a literature review: Part 2--Clinical use
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Recommended use of morphine in neonates, infants and children based on a literature review : Part 2--Clinical use. / Kart, T; Christrup, Lona Louring; Rasmussen, M.
In: Paediatric Anaesthesia, Vol. 7, No. 2, 1997, p. 93-101.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Recommended use of morphine in neonates, infants and children based on a literature review
T2 - Part 2--Clinical use
AU - Kart, T
AU - Christrup, Lona Louring
AU - Rasmussen, M
PY - 1997
Y1 - 1997
N2 - The indication for morphine use is primarily pain, but also a combined analgesic and sedative effect may be the rationale behind morphine administration. Paediatric morphine regimens have been reported for children with postoperative pain, pain related to cancer, sickle cell crisis pain, burns and AIDS. No dose response curve for morphine in neonates, infants or children has been established, and different levels for the minimum effective plasma concentration have been estimated. The side effects observed in neonates, infants, and children are similar to those observed in adults, and neonates do not seem to be more susceptible to respiratory depression than older children. Despite shortcomings in the knowledge of the pharmacodynamics of morphine, it can be considered safe to administer morphine to neonates, infants or children. Initial regimens has been calculated from the pharmacokinetic parameters of morphine, but treatment must be adjusted according to analgesic effect and incidence of side effects.
AB - The indication for morphine use is primarily pain, but also a combined analgesic and sedative effect may be the rationale behind morphine administration. Paediatric morphine regimens have been reported for children with postoperative pain, pain related to cancer, sickle cell crisis pain, burns and AIDS. No dose response curve for morphine in neonates, infants or children has been established, and different levels for the minimum effective plasma concentration have been estimated. The side effects observed in neonates, infants, and children are similar to those observed in adults, and neonates do not seem to be more susceptible to respiratory depression than older children. Despite shortcomings in the knowledge of the pharmacodynamics of morphine, it can be considered safe to administer morphine to neonates, infants or children. Initial regimens has been calculated from the pharmacokinetic parameters of morphine, but treatment must be adjusted according to analgesic effect and incidence of side effects.
KW - Age Factors
KW - Analgesics, Opioid
KW - Child
KW - Humans
KW - Infant
KW - Infant, Newborn
KW - Morphine
KW - Pain
M3 - Journal article
C2 - 9188108
VL - 7
SP - 93
EP - 101
JO - Paediatric Anaesthesia
JF - Paediatric Anaesthesia
SN - 1155-5645
IS - 2
ER -
ID: 46098976