Recommended use of morphine in neonates, infants and children based on a literature review: Part 1--Pharmacokinetics

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Recommended use of morphine in neonates, infants and children based on a literature review : Part 1--Pharmacokinetics. / Kart, T; Christrup, Lona Louring; Rasmussen, M.

In: Paediatric Anaesthesia, Vol. 7, No. 1, 1997, p. 5-11.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kart, T, Christrup, LL & Rasmussen, M 1997, 'Recommended use of morphine in neonates, infants and children based on a literature review: Part 1--Pharmacokinetics', Paediatric Anaesthesia, vol. 7, no. 1, pp. 5-11. <https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1155-5645&date=1997&volume=7&issue=1&spage=5>

APA

Kart, T., Christrup, L. L., & Rasmussen, M. (1997). Recommended use of morphine in neonates, infants and children based on a literature review: Part 1--Pharmacokinetics. Paediatric Anaesthesia, 7(1), 5-11. https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1155-5645&date=1997&volume=7&issue=1&spage=5

Vancouver

Kart T, Christrup LL, Rasmussen M. Recommended use of morphine in neonates, infants and children based on a literature review: Part 1--Pharmacokinetics. Paediatric Anaesthesia. 1997;7(1):5-11.

Author

Kart, T ; Christrup, Lona Louring ; Rasmussen, M. / Recommended use of morphine in neonates, infants and children based on a literature review : Part 1--Pharmacokinetics. In: Paediatric Anaesthesia. 1997 ; Vol. 7, No. 1. pp. 5-11.

Bibtex

@article{318902f5500b4d0491ee4df6efb2d190,
title = "Recommended use of morphine in neonates, infants and children based on a literature review: Part 1--Pharmacokinetics",
abstract = "The English language literature has been reviewed in order to evaluate the present knowledge on morphine's metabolism and pharmacokinetics in children. The majority of preterm neonates are capable of glucuronidating morphine, but birth weight; gestational and postnatal age influence the glucuronidation capability. Term neonates, infants, and children are able to produce morphine glucuronides. For the reported pharmacokinetics parameters a meta-analysis was made; volume of distribution, estimated to be 2.8 +/- 2.6 l.kg-1, seems to be regardless of age, while half-life and clearance were found to be related to age. Half-life was estimated to be 9.0 +/- 3.4 h in pre-term neonates, 6.5 +/- 2.8 h in term neonates aged 0-57 days, and 2.0 +/- 1.8 h for infants and children aged 11 days to 15 years. Clearance was estimated to be 2.2 +/- 0.7 ml.min-1.kg-1 for preterm neonates, 8.1 +/- 3.2 ml.min-1.kg-1 in term neonates aged 0-57 days, and 23.6 +/- 8.5 ml.min-1.kg-1 in infants and children more than 11 days old.",
keywords = "Adolescent, Age Factors, Analgesics, Opioid, Child, Child, Preschool, Glucuronates, Half-Life, Humans, Infant, Infant, Newborn, Infant, Premature, Morphine",
author = "T Kart and Christrup, {Lona Louring} and M Rasmussen",
year = "1997",
language = "English",
volume = "7",
pages = "5--11",
journal = "Paediatric Anaesthesia",
issn = "1155-5645",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Recommended use of morphine in neonates, infants and children based on a literature review

T2 - Part 1--Pharmacokinetics

AU - Kart, T

AU - Christrup, Lona Louring

AU - Rasmussen, M

PY - 1997

Y1 - 1997

N2 - The English language literature has been reviewed in order to evaluate the present knowledge on morphine's metabolism and pharmacokinetics in children. The majority of preterm neonates are capable of glucuronidating morphine, but birth weight; gestational and postnatal age influence the glucuronidation capability. Term neonates, infants, and children are able to produce morphine glucuronides. For the reported pharmacokinetics parameters a meta-analysis was made; volume of distribution, estimated to be 2.8 +/- 2.6 l.kg-1, seems to be regardless of age, while half-life and clearance were found to be related to age. Half-life was estimated to be 9.0 +/- 3.4 h in pre-term neonates, 6.5 +/- 2.8 h in term neonates aged 0-57 days, and 2.0 +/- 1.8 h for infants and children aged 11 days to 15 years. Clearance was estimated to be 2.2 +/- 0.7 ml.min-1.kg-1 for preterm neonates, 8.1 +/- 3.2 ml.min-1.kg-1 in term neonates aged 0-57 days, and 23.6 +/- 8.5 ml.min-1.kg-1 in infants and children more than 11 days old.

AB - The English language literature has been reviewed in order to evaluate the present knowledge on morphine's metabolism and pharmacokinetics in children. The majority of preterm neonates are capable of glucuronidating morphine, but birth weight; gestational and postnatal age influence the glucuronidation capability. Term neonates, infants, and children are able to produce morphine glucuronides. For the reported pharmacokinetics parameters a meta-analysis was made; volume of distribution, estimated to be 2.8 +/- 2.6 l.kg-1, seems to be regardless of age, while half-life and clearance were found to be related to age. Half-life was estimated to be 9.0 +/- 3.4 h in pre-term neonates, 6.5 +/- 2.8 h in term neonates aged 0-57 days, and 2.0 +/- 1.8 h for infants and children aged 11 days to 15 years. Clearance was estimated to be 2.2 +/- 0.7 ml.min-1.kg-1 for preterm neonates, 8.1 +/- 3.2 ml.min-1.kg-1 in term neonates aged 0-57 days, and 23.6 +/- 8.5 ml.min-1.kg-1 in infants and children more than 11 days old.

KW - Adolescent

KW - Age Factors

KW - Analgesics, Opioid

KW - Child

KW - Child, Preschool

KW - Glucuronates

KW - Half-Life

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Infant, Premature

KW - Morphine

M3 - Journal article

C2 - 9041568

VL - 7

SP - 5

EP - 11

JO - Paediatric Anaesthesia

JF - Paediatric Anaesthesia

SN - 1155-5645

IS - 1

ER -

ID: 46098997