TY - JOUR

T1 - The Concise Guide to PHARMACOLOGY 2023/24

T2 - Ion channels

AU - Alexander, Stephen P H

AU - Mathie, Alistair A

AU - Peters, John A

AU - Veale, Emma L

AU - Striessnig, Jörg

AU - Kelly, Eamonn

AU - Armstrong, Jane F

AU - Faccenda, Elena

AU - Harding, Simon D

AU - Davies, Jamie A

AU - Aldrich, Richard W

AU - Attali, Bernard

AU - Baggetta, Austin M

AU - Becirovic, Elvir

AU - Biel, Martin

AU - Bill, Roslyn M

AU - Caceres, Ana I

AU - Catterall, William A

AU - Conner, Alex C

AU - Davies, Paul

AU - De Clerq, Katrien

AU - Delling, Markus

AU - Di Virgilio, Francesco

AU - Falzoni, Simonetta

AU - Fenske, Stefanie

AU - Fortuny-Gomez, Anna

AU - Fountain, Samuel

AU - George, Chandy

AU - Goldstein, Steve A N

AU - Grimm, Christian

AU - Grissmer, Stephan

AU - Ha, Kotdaji

AU - Hammelmann, Verena

AU - Hanukoglu, Israel

AU - Hu, Meiqin

AU - Ijzerman, Ad P

AU - Jabba, Sairam V

AU - Jarvis, Mike

AU - Jensen, Anders A

AU - Jordt, Sven E

AU - Kaczmarek, Leonard K

AU - Kellenberger, Stephan

AU - Kennedy, Charles

AU - King, Brian

AU - Kitchen, Philip

AU - Liu, Qiang

AU - Lynch, Joseph W

AU - Meades, Jessica

AU - Mehlfeld, Verena

AU - Nicke, Annette

AU - Offermanns, Stefan

AU - Perez-Reyes, Edward

AU - Plant, Leigh D

AU - Rash, Lachlan

AU - Ren, Dejian

AU - Salman, Mootaz M

AU - Sieghart, Werner

AU - Sivilotti, Lucia G

AU - Smart, Trevor G

AU - Snutch, Terrance P

AU - Tian, Jinbin

AU - Trimmer, James S

AU - Van den Eynde, Charlotte

AU - Vriens, Joris

AU - Wei, Aguan D

AU - Winn, Brenda T

AU - Wulff, Heike

AU - Xu, Haoxing

AU - Yang, Fan

AU - Fang, Wei

AU - Yue, Lixia

AU - Zhang, Xiaoli

AU - Zhu, Michael

N1 - © 2023 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of The British Pharmacological Society.

PY - 2023

Y1 - 2023

N2 - The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org/), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at https://onlinelibrary.wiley.com/doi/10.1111/bph.16178. Ion channels are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

AB - The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org/), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at https://onlinelibrary.wiley.com/doi/10.1111/bph.16178. Ion channels are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

KW - Humans

KW - Databases, Pharmaceutical

KW - Ion Channels/chemistry

KW - Ligands

KW - Receptors, G-Protein-Coupled

KW - Databases, Factual

KW - Pharmacology

U2 - 10.1111/bph.16178

DO - 10.1111/bph.16178

M3 - Journal article

C2 - 38123150

VL - 180

SP - S145-S222

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

SN - 0007-1188

IS - Suppl 2

ER -