The enzymatic degradation and transport of leucine-enkephalin and 4-imidazolidinone enkephalin prodrugs at the blood-brain barrier

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The enzymatic degradation and transport of leucine-enkephalin and 4-imidazolidinone enkephalin prodrugs at the blood-brain barrier. / Lund, L.; Bak, A.; Friis, G.J.; Hovgaard, L.; Christrup, Lona Louring.

In: International Journal of Pharmaceutics, Vol. 172, No. 1-2, 15.10.1998, p. 97-101.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lund, L, Bak, A, Friis, GJ, Hovgaard, L & Christrup, LL 1998, 'The enzymatic degradation and transport of leucine-enkephalin and 4-imidazolidinone enkephalin prodrugs at the blood-brain barrier', International Journal of Pharmaceutics, vol. 172, no. 1-2, pp. 97-101. https://doi.org/10.1016/S0378-5173(98)00192-6

APA

Lund, L., Bak, A., Friis, G. J., Hovgaard, L., & Christrup, L. L. (1998). The enzymatic degradation and transport of leucine-enkephalin and 4-imidazolidinone enkephalin prodrugs at the blood-brain barrier. International Journal of Pharmaceutics, 172(1-2), 97-101. https://doi.org/10.1016/S0378-5173(98)00192-6

Vancouver

Lund L, Bak A, Friis GJ, Hovgaard L, Christrup LL. The enzymatic degradation and transport of leucine-enkephalin and 4-imidazolidinone enkephalin prodrugs at the blood-brain barrier. International Journal of Pharmaceutics. 1998 Oct 15;172(1-2):97-101. https://doi.org/10.1016/S0378-5173(98)00192-6

Author

Lund, L. ; Bak, A. ; Friis, G.J. ; Hovgaard, L. ; Christrup, Lona Louring. / The enzymatic degradation and transport of leucine-enkephalin and 4-imidazolidinone enkephalin prodrugs at the blood-brain barrier. In: International Journal of Pharmaceutics. 1998 ; Vol. 172, No. 1-2. pp. 97-101.

Bibtex

@article{1e04eca457fb49a5a0658f2bc6c1eae5,
title = "The enzymatic degradation and transport of leucine-enkephalin and 4-imidazolidinone enkephalin prodrugs at the blood-brain barrier",
abstract = "In this study, the stability in and transport across a cell culture model of the blood-brain barrier (BBB) is investigated for leucine-enkephalin (Leu-enkephalin) and four 4-imidazolidinone prodrugs of Leu-enkephalin. The results show that Leu-enkephalin is degraded in the cell culture model of the BBB both by cytosolic and plasma membrane bound enzymes. It is likely that aminopeptidase is the predominant enzyme responsible for the degradation of Leu-enkephalin. All four 4-imidazolidinone prodrugs of Leu-enkephalin examined showed an increased stability of Leu-enkephalin against degradation by both plasma membrane bound and cytosolic enzymes. Consequently, the transport properties of Leu-enkephalin is also improved by up to 60% by formation of 4-imidazolidinone prodrugs. Copyright (C) 1998 Elsvier Science B.V.",
author = "L. Lund and A. Bak and G.J. Friis and L. Hovgaard and Christrup, {Lona Louring}",
year = "1998",
month = oct,
day = "15",
doi = "10.1016/S0378-5173(98)00192-6",
language = "English",
volume = "172",
pages = "97--101",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - The enzymatic degradation and transport of leucine-enkephalin and 4-imidazolidinone enkephalin prodrugs at the blood-brain barrier

AU - Lund, L.

AU - Bak, A.

AU - Friis, G.J.

AU - Hovgaard, L.

AU - Christrup, Lona Louring

PY - 1998/10/15

Y1 - 1998/10/15

N2 - In this study, the stability in and transport across a cell culture model of the blood-brain barrier (BBB) is investigated for leucine-enkephalin (Leu-enkephalin) and four 4-imidazolidinone prodrugs of Leu-enkephalin. The results show that Leu-enkephalin is degraded in the cell culture model of the BBB both by cytosolic and plasma membrane bound enzymes. It is likely that aminopeptidase is the predominant enzyme responsible for the degradation of Leu-enkephalin. All four 4-imidazolidinone prodrugs of Leu-enkephalin examined showed an increased stability of Leu-enkephalin against degradation by both plasma membrane bound and cytosolic enzymes. Consequently, the transport properties of Leu-enkephalin is also improved by up to 60% by formation of 4-imidazolidinone prodrugs. Copyright (C) 1998 Elsvier Science B.V.

AB - In this study, the stability in and transport across a cell culture model of the blood-brain barrier (BBB) is investigated for leucine-enkephalin (Leu-enkephalin) and four 4-imidazolidinone prodrugs of Leu-enkephalin. The results show that Leu-enkephalin is degraded in the cell culture model of the BBB both by cytosolic and plasma membrane bound enzymes. It is likely that aminopeptidase is the predominant enzyme responsible for the degradation of Leu-enkephalin. All four 4-imidazolidinone prodrugs of Leu-enkephalin examined showed an increased stability of Leu-enkephalin against degradation by both plasma membrane bound and cytosolic enzymes. Consequently, the transport properties of Leu-enkephalin is also improved by up to 60% by formation of 4-imidazolidinone prodrugs. Copyright (C) 1998 Elsvier Science B.V.

UR - http://www.scopus.com/inward/record.url?scp=0032531892&partnerID=8YFLogxK

U2 - 10.1016/S0378-5173(98)00192-6

DO - 10.1016/S0378-5173(98)00192-6

M3 - Journal article

AN - SCOPUS:0032531892

VL - 172

SP - 97

EP - 101

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -

ID: 46100453