The Sabatier principle as a tool for discovery and engineering of industrial enzymes
Research output: Contribution to journal › Review › Research › peer-review
Documents
- Fulltext
Final published version, 3.82 MB, PDF document
The recent breakthrough in all-atom, protein structure prediction opens new avenues for a range of computational approaches in enzyme design. These new approaches could become instrumental for the development of technical biocatalysts, and hence our transition toward more sustainable industries. Here, we discuss one approach, which is well-known within inorganic catalysis, but essentially unexploited in biotechnology. Specifically, we review examples of linear freeenergy relationships (LFERs) for enzyme reactions and discuss how LFERs and the associated Sabatier Principle may be implemented in algorithms that estimate kinetic parameters and enzyme performance based on model structures.
Original language | English |
---|---|
Article number | 102843 |
Journal | Current Opinion in Biotechnology |
Volume | 78 |
Number of pages | 7 |
ISSN | 0958-1669 |
DOIs | |
Publication status | Published - 2022 |
- Abbreviations, LFER, Linear free energy relationship, SP, Sabatier, Principle, BINDING, ENERGY, HYDROLASES
Research areas
ID: 334647296