Stephan Pless
Professor
Biopharmaceuticals
Jagtvej 162
2100 København Ø
- Published
Conformational variability of the glycine receptor M2 domain in response to activation by different agonists
Pless, Stephan, Dibas, M. I., Lester, H. A. & Lynch, J. W., 7 Dec 2007, In: The Journal of Biological Chemistry. 282, 49, p. 36057-67 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Asymmetric functional contributions of acidic and aromatic side chains in sodium channel voltage-sensor domains
Pless, Stephan, Elstone, F. D., Niciforovic, A. P., Galpin, J. D., Yang, R., Kurata, H. T. & Ahern, C. A., May 2014, In: Journal of General Physiology. 143, 5, p. 645-56 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A cation-π interaction at a phenylalanine residue in the glycine receptor binding site is conserved for different agonists
Pless, Stephan, Hanek, A. P., Price, K. L., Lynch, J. W., Lester, H. A., Dougherty, D. A. & Lummis, S. C. R., Apr 2011, In: Molecular Pharmacology. 79, 4, p. 742-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Distinct conformational changes in activated agonist-bound and agonist-free glycine receptor subunits
Pless, Stephan & Lynch, J. W., Mar 2009, In: Journal of Neurochemistry. 108, 6, p. 1585-94 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A cation-pi interaction in the binding site of the glycine receptor is mediated by a phenylalanine residue
Pless, Stephan, Millen, K. S., Hanek, A. P., Lynch, J. W., Lester, H. A., Lummis, S. C. R. & Dougherty, D. A., 22 Oct 2008, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 28, 43, p. 10937-42 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Magnitude of a conformational change in the glycine receptor beta1-beta2 loop is correlated with agonist efficacy
Pless, Stephan & Lynch, J. W., 2 Oct 2009, In: The Journal of Biological Chemistry. 284, 40, p. 27370-6 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Unnatural amino acids as probes of ligand-receptor interactions and their conformational consequences
Pless, Stephan & Ahern, C. A., 2013, In: Annual Review of Pharmacology and Toxicology. 53, p. 211-29 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Atom-by-atom engineering of voltage-gated ion channels: Magnified insights into function and pharmacology
Pless, Stephan, Kim, R. Y., Ahern, C. A. & Kurata, H. T., 30 Jan 2015, In: The Journal of Physiology. 593, 12, p. 2627–2634 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A novel mechanism for fine-tuning open-state stability in a voltage-gated potassium channel
Pless, Stephan, Niciforovic, A. P., Galpin, J. D., Nunez, J., Kurata, H. T. & Ahern, C. A., 2013, In: Nature Communications. 4, p. 1784Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Contributions of conserved residues at the gating interface of glycine receptors
Pless, Stephan, Leung, A. W. Y., Galpin, J. D. & Ahern, C. A., 7 Oct 2011, In: The Journal of Biological Chemistry. 286, 40, p. 35129-36 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ligand-specific conformational changes in the alpha1 glycine receptor ligand-binding domain
Pless, Stephan & Lynch, J. W., 5 Jun 2009, In: The Journal of Biological Chemistry. 284, 23, p. 15847-56 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional modulation of a pH-sensitive ion channel by a transporter family
Poulsen, Mette Homann, Xue, F., Maurya, S. R., Kickinger, Stefanie, Usher, Samuel George, Wellendorph, Petrine, Lundby, Alicia & Pless, Stephan, 2023, In: Biophysical Journal. 122, 3 Suppl. 1, p. 249aResearch output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Elucidating the Function and Cell-Specific Interactions of P2X7 Receptor Variants Linked to Mental Disorders
Poulsen, Mette Homann, Fang, J. & Pless, Stephan, 2019, p. 109A-110A.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Expression-dependent pharmacology of transient receptor potential vanilloid subtype 1 channels in Xenopus laevis oocytes
Rivera-Acevedo, R. E., Pless, Stephan, Schwarz, S. K. W. & Ahern, C. A., 1 Jan 2013, In: Channels (Austin). 7, 1, p. 47-50 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The quaternary lidocaine derivative, QX-314, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro
Rivera-Acevedo, R. E., Pless, Stephan, Ahern, C. A. & Schwarz, S. K. W., Jun 2011, In: Anesthesiology. 114, 6, p. 1425-34 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Extracellular quaternary ammonium blockade of transient receptor potential vanilloid subtype 1 channels expressed in Xenopus laevis oocytes
Rivera-Acevedo, R. E., Pless, Stephan, Schwarz, S. K. W. & Ahern, C. A., Dec 2012, In: Molecular Pharmacology. 82, 6, p. 1129-35 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Accepted/In press
Protein semisynthesis underscores the role of a conserved lysine in activation and desensitization of acid-sensing ion channels
Sarkar, Debayan, Galleano, I., Heusser, Stephanie, Ou, S. Y., Uzun, G. R., Khoo, K. K., van der Heden van Noort, G. J., Harrison, J. S. & Pless, Stephan, 2024, (Accepted/In press) In: Cell Chemical Biology.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ion channel engineering using protein trans-splicing
Sarkar, Debayan, Harms, Hendrik, Galleano, I., Sheikh, Zeshan Pervez & Pless, Stephan, 2021, Methods in Enzymology. Elsevier, p. 19-48 30 p. (Methods in Enzymology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Probing Backbone Hydrogen Bonds in Proteins by Amide-to-Ester Mutations
Sereikaité, Vita, Jensen, T. M. T., Bartling, Christian Reinhard Otto, Jemth, P., Pless, Stephan & Strømgaard, Kristian, 18 Oct 2018, In: ChemBioChem. 19, 20, p. 2136-2145Research output: Contribution to journal › Review › Research › peer-review
- Published
Phenotypic Spectrum of HCN4 Mutations: A Clinical Case
Servatius, H., Porro, A., Pless, Stephan, Schaller, A., Asatryan, B., Tanner, H., de Marchi, S. F., Roten, L., Seiler, J., Haeberlin, A., Baldinger, S. H., Noti, F., Lam, A., Fuhrer, J., Moroni, A. & Medeiros-Domingo, A., Feb 2018, In: Circulation. Genomic and precision medicine. 11, 2, e002033.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The M1 and pre-M1 segments contribute differently to ion selectivity in ASICs and ENaCs
Sheikh, Zeshan Pervez, Wulf, M., Friis, S., Althaus, M., Lynagh, T. & Pless, Stephan, 2021, In: Journal of General Physiology. 153, 10, 23 p., e202112899.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Indirect Determinants of Ion Selectivity in Acid-Sensing Ion Channels and Epithelial Sodium Channels
Sheikh, Zeshan Pervez, Lynagh, T., Kristensen, Anders Skov & Pless, Stephan, 2019, p. 110A-110A.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Ion Selectivity in Acid-Sensing Ion Channels and Epithelial Sodium Channels
Sheikh, Zeshan Pervez, Lynagh, T. P. & Pless, Stephan, 2 Feb 2018, p. 24A-24A.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Four drug-sensitive subunits are required for maximal effect of a voltage sensor-targeted KCNQ opener
Wang, A. W., Yau, M. C., Wang, C. K., Sharmin, N., Yang, R. Y., Pless, Stephan & Kurata, H. T., 30 Aug 2018, In: Journal of General Physiology. 150, 10, p. 1432-1443 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ligand- and subunit-specific conformational changes in the ligand-binding domain and the TM2-TM3 linker of {alpha}1 {beta}2 {gamma}2 GABAA receptors
Wang, Q., Pless, Stephan & Lynch, J. W., 17 Dec 2010, In: The Journal of Biological Chemistry. 285, 51, p. 40373-86 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional Characterization of Disease-Causing Mutations in the Sodium Leak Channel NALCN
wbv551, wbv551, Ameen, A. O., Chua, H. C. & Pless, Stephan, 2021, p. 10A-11A.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
High-Sensitivity Fluorometry to Resolve Ion Channel Conformational Dynamics
Wulf, M. & Pless, Stephan, 6 Feb 2018, In: Cell Reports. 22, 6, p. 1615-1626 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A New Method to Detect Intra- and Extracellular Conformational Changes in Ion Channels with High Temporal Resolution
Wulf, M. & Pless, Stephan, 3 Feb 2017, In: Biophysical Journal. 12, 3, p. 285A-285AResearch output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
One drug-sensitive subunit is sufficient for a nearmaximal retigabine effect in KCNQ channels
Yau, M. C., Kim, R. Y., Wang, C. K., Li, J., Ammar, T., Yang, R. Y., Pless, Stephan & Kurata, H. T., 1 Oct 2018, In: Journal of General Physiology. 215, 10, p. 1421-1431 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A conserved residue cluster that governs kinetics of ATP-dependent gating of Kir6.2 potassium channels
Zhang, R. S., Wright, J., Pless, Stephan, Nunez, J., Kim, R. Y., Li, J. B. W., Yang, R., Ahern, C. A. & Kurata, H. T., 2015, In: The Journal of Biological Chemistry. 290, 25, p. 15450 –15461 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 93715174
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Unique contributions of an arginine side chain to ligand recognition in a glutamate-gated chloride channel
Research output: Contribution to journal › Journal article › Research › peer-review
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High-Sensitivity Fluorometry to Resolve Ion Channel Conformational Dynamics
Research output: Contribution to journal › Journal article › Research › peer-review
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A selectivity filter at the intracellular end of the acid-sensing ion channel pore
Research output: Contribution to journal › Journal article › Research › peer-review
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