David E. Gloriam
Professor
Pharmaceutical Informatics
Universitetsparken 2
2100 København Ø
- Published
Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analogs
Krall, J., Jensen, C. H., Bavo, F., Falk-Petersen, C. B., Haugaard, A. S., Vogensen, S. B., Tian, Y., Nittegaard-Nielsen, M., Sigurdardóttir, S. B., Kehler, J., Kongstad, Kenneth Thermann, Gloriam, David E., Clausen, Rasmus Prætorius, Harpsøe, Kasper, Wellendorph, Petrine & Frølund, Bente, 2017, In: Journal of Medicinal Chemistry. 60, 21, p. 9022-9039 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular Determinants underlying Delta Selective Compound 2 (DS2) Activity at δ-Containing GABAA Receptors
Falk-Petersen, C. B., Rostrup, F., Löffler, R., Buchleihtner, S., Harpsøe, Kasper, Gloriam, David E., Frølund, Bente & Wellendorph, Petrine, 2021, In: Molecular Pharmacology. 100, 1, p. 46-56Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Modulation in selectivity and allosteric properties of small-molecule ligands for CC-chemokine receptors
Thiele, S., Malmgaard-Clausen, M., Engel-Andreasen, J., Steen, A., Rummel, P. C., Nielsen, M. C., Gloriam, David E., Frimurer, Thomas Michael, Ulven, Trond & Rosenkilde, Mette, 27 Sep 2012, In: Journal of Medicinal Chemistry. 55, 18, p. 8164-77 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Minimum information about a protein affinity reagent (MIAPAR)
Bourbeillon, J., Orchard, S., Benhar, I., Borrebaeck, C., de Daruvar, A., Dübel, S., Frank, R., Gibson, F., Gloriam, D. E. I., Haslam, N., Hiltker, T., Humphrey-Smith, I., Hust, M., Juncker, D., Koegl, M., Konthur, Z., Korn, B., Krobitsch, S., Muyldermans, S., Nygren, P-Å. & 14 others, , 2010, In: Nature Biotechnology. 28, 7, p. 650-653Research output: Contribution to journal › Journal article › Research
- Published
Methods for the successful application of chemogenomics to GPCR drug design
Garland, S. L. (ed.) & Gloriam, David E. (ed.), 2011, In: Current Topics in Medicinal Chemistry. 11, 15, p. 1870-1871Research output: Contribution to journal › Editorial › Research
- Published
Ligand-directed bias of G protein signaling at the dopamine D2 receptor
Moo, Ee Von, Harpsøe, Kasper, Hauser, Alexander Sebastian, Masuho, I., Bräuner, Hans, Gloriam, David E. & Martemyanov, K. A., 2022, In: Cell Chemical Biology. 29, 2, p. 226-238Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ligand selectivity hotspots in serotonin GPCRs
Simon, Icaro A, Bjørn-Yoshimoto, Walden, Harpsøe, Kasper, Iliadis, S., Svensson, B., Jensen, Anders A. & Gloriam, David E., 2023, In: Trends in Pharmacological Sciences. 44, 12, p. 978-990Research output: Contribution to journal › Review › Research › peer-review
- Published
Kemogenomik: Receptoren set fra lægemiddelstoffets synspunkt
Johansson, H., Jørgensen, T. B., Gloriam, David E., Wellendorph, Petrine, Johansen, L. D., Pedersen, D. S. & Bräuner, Hans, 2011, In: Dansk Kemi. 92, 11, p. 22-26Research output: Contribution to journal › Journal article › Research
- Published
Kemogenomik: receptoren set fra lægemiddelstoffets synspunkt
Gloriam, David E., Wellendorph, Petrine, Johansen, L. D., Pedersen, D. S. & Bräuner, Hans, Dec 2010, In: Lægemiddelforskning. 2010, p. 28-30Research output: Contribution to journal › Journal article › Communication
- Published
Integrating structural and mutagenesis data to elucidate GPCR ligand binding
Munk, C., Harpsøe, Kasper, Hauser, Alexander Sebastian, Isberg, V. & Gloriam, David E., Oct 2016, In: Current Opinion in Pharmacology. 30, p. 51-58 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In silico identification of novel G protein-coupled receptors
Davies, M. N., Gloriam, David E. & Flower, D. R., 2011, Methods for the discovery and characterization of G protein-coupled receptors. Stevens, C. W. (ed.). New York: Humana Press, Vol. 60. p. 3-18 (Neuromethods, Vol. 60).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Identification of the first surrogate agonists for the G protein-coupled receptor GPR132
Shehata, M. A., Christensen, H. B., Isberg, V., Pedersen, D. S., Bender, A., Bräuner, Hans & Gloriam, David E., 2015, In: RSC Advances. 5, p. 48551-48557 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of a novel scaffold for a small molecule GPR139 receptor agonist
Nøhr, A. C., Shehata, M. A., Palmer, D., Pokhrel, R., Vallianou, M., Foster, S. R., Gentry, P. R., Gloriam, David E. & Bräuner, Hans, 7 Mar 2019, In: Scientific Reports. 9, 1, 10 p., 3802.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of Histamine H3 Receptor Ligands Using a New Crystal Structure Fragment-based Method
Frandsen, I. O., Boesgaard, M. W., Fidom, K., Hauser, Alexander Sebastian, Isberg, V., Bräuner, Hans, Wellendorph, Petrine & Gloriam, David E., 6 Jul 2017, In: Scientific Reports. 7, 1, 10 p., 4829.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification and characterization of small molecular NPR-B receptor antagonists
Andresen, H., Moltzau, L., Fagerheim, S., Gloriam, David E., Bach, T. & Levy, F., 1 Jan 2015, In: BMC Pharmacology and Toxicology. 16, Suppl 1, p. A70Research output: Contribution to journal › Journal article › Communication
- Published
How can I teach to maximize the learning of “Roberts” (slow/nonambitious) and “Susans” (fast/ambitious)? Improving University Science Teaching and Learning - Pedagogical Projects 2008
Gloriam, David E., 2008, Improving University Science Teaching and Learning - Pedagogical Projects 2008. Christiansen, F. V., Rump, C. & Degn, L. (eds.). København: Department of Science Education, University of Copenhagen, Denmark, Vol. 1. p. 227-244 18 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
High species variation within the repertoire of trace amine receptors
Gloriam, David E., Bjarnadóttir, T. K., Schiöth, H. B. & Fredriksson, R., Apr 2005, In: Annals of the New York Academy of Sciences. 5 p.Research output: Contribution to journal › Conference article › Research
- Published
GproteinDb in 2024: new G protein-GPCR couplings, AlphaFold2-multimer modelsãnd interface interactions
Pándy-Szeker es, G., Taracena Herrera, Luis Pablo, Caroli, J., Kermani, A. A., Kulkarni, Yashraj, Keseru, G. M. & Gloriam, David E., 2024, In: Nucleic Acids Research. 52, D1, p. D466-D475Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Generic GPCR residue numbers - aligning topology maps while minding the gaps
Isberg, V., de Graaf, C., Bortolato, A., Cherezov, V., Katritch, V., Marshall, F. H., Mordalski, S., Pin, J., Stevens, R. C., Vriend, G. & Gloriam, David E., 1 Jan 2015, In: Trends in Pharmacological Sciences. 36, 1, p. 22-31 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors
Huang, S., Xu, P., Shen, D., Simon, Icaro A, Mao, C., Tan, Y., Zhang, H., Harpsøe, Kasper, Li, H., Zhang, Y., You, C., Yu, X., Jiang, Y., Zhang, Y., Gloriam, David E. & Xu, H. E., 2022, In: Molecular Cell. 82, 14, p. 2681-2695.e6 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPCRmd uncovers the dynamics of the 3D-GPCRome
Rodríguez-Espigares, I., Torrens-Fontanals, M., Tiemann, J. K. S., Aranda-García, D., Ramírez-Anguita, J. M., Stepniewski, T. M., Worp, N., Varela-Rial, A., Morales-Pastor, A., Medel-Lacruz, B., Pándy-Szekeres, G., Mayol, E., Giorgino, T., Carlsson, J., Deupi, X., Filipek, S., Filizola, M., Gómez-Tamayo, J. C., Gonzalez, A., Gutiérrez-de-Terán, H. & 27 others, , 2020, In: Nature Methods. 17, 8, p. 777-787Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPCRdb: The G protein-coupled receptor database - an introduction
Munk, C., Isberg, V., Mordalski, S., Harpsøe, Kasper, Rataj, K., Hauser, Alexander Sebastian, Kolb, P., Bojarski, A. J., Vriend, G. & Gloriam, David E., Jul 2016, In: British Journal of Pharmacology. 173, 14, p. 2195-207 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPCRdb in 2023: state-specific structure models using AlphaFold2 and new ligand resources
Pándy-Szekeres, Gáspár, Caroli, J., Mamyrbekov, A., Kermani, A. A., Keserű, G. M., Kooistra, Albert J. & Gloriam, David E., 2023, In: Nucleic Acids Research. 51, D1, p. D395–D402Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPCRdb in 2021: integrating GPCR sequence, structure and function
Kooistra, Albert J., Mordalski, S., Pándy-Szekeres, Gáspár, Esguerra, M., Mamyrbekov, A., Munk, C., Keserű, G. M. & Gloriam, David E., 2021, In: Nucleic Acids Research. 49, D1, p. D335-D343Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPCRdb in 2018: adding GPCR structure models and ligands
Pándy-Szekeres, Gáspár, Munk, C., Tsonkov, T. M., Mordalski, S., Harpsøe, Kasper, Hauser, Alexander Sebastian, Bojarski, A. J. & Gloriam, David E., 2018, In: Nucleic Acids Research. 46, D1, 7 p., gkx1109.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPCRdb: an information system for G protein-coupled receptors
Isberg, V., Mordalski, S., Munk, C., Rataj, K., Harpsøe, Kasper, Hauser, Alexander Sebastian, Vroling, B., Bojarski, A. J., Vriend, G. & Gloriam, David E., 4 Jan 2016, In: Nucleic Acids Research. 44, D1, p. D356-64Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPCRDB: an information system for G protein-coupled receptors
Ísberg, V., Vroling, B., van der Kant, R., Li, K., Vriend, G. & Gloriam, David E., Jan 2014, In: Nucleic Acids Research. 42, Database issue, p. D422-D425Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPCR activation mechanisms across classes and macro/microscales
Hauser, Alexander Sebastian, Kooistra, Albert J., Munk, C., Heydenreich, F. M., Veprintsev, D. B., Bouvier, M., Babu, M. M. & Gloriam, David E., 2021, In: Nature Structural and Molecular Biology. 28, 11, p. 879-888Research output: Contribution to journal › Journal article › Research › peer-review
- Published
G protein-coupled receptor pharmacology-The next generation
Bräuner, Hans, Rosenkilde, Mette, Gether, Ulrik & Gloriam, David E., 2020, In: Basic & Clinical Pharmacology & Toxicology. 126, Supplement 6, p. 3-4 2 p.Research output: Contribution to journal › Editorial › Research
- Published
G protein- and agonist-bound serotonin 5-HT2A receptor model activated by steered molecular dynamics simulations
Ísberg, V., Balle, T., Sander, T., Jørgensen, Flemming Steen & Gloriam, David E., 28 Feb 2011, In: Journal of Chemical Information and Modeling. 51, 2, p. 315-325Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Five-membered N-heterocyclic Scaffolds as Novel Amino Bioisosteres at gamma-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters
Giraudo, A., Krall, J., Bavo, Francesco, Nielsen, Birgitte, Kongstad, Kenneth Thermann, Rolando, B., De Blasio, R., Gloriam, David E., Löffler, R., Thiesen, L., Harpsøe, Kasper, Frydenvang, Karla Andrea, Boschi, D., Wellendorph, Petrine, Lolli, M. L., Jensen, Anders A. & Frølund, Bente, 27 Jun 2019, In: Journal of Medicinal Chemistry. 62, 12, p. 5797-5809Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs
Avet, C., Mancini, A., Breton, B., Le Gouill, C., Hauser, Alexander Sebastian, Normand, C., Kobayashi, H., Gross, F., Hogue, M., Lukasheva, V., St-Onge, S., Carrier, M., Héroux, M., Morissette, S., Fauman, E. B., Fortin, J. P., Schann, S., Leroy, X., Gloriam, David E. & Bouvier, M., 2022, In: eLife. 11, 34 p., e74101.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Editorial overview: New technologies: GPCR drug design and function-exploiting the current (of) structures
Tautermann, C. S. & Gloriam, David E., 2 Aug 2016, In: Current Opinion in Pharmacology. 30, p. 7-10 4 p.Research output: Contribution to journal › Comment/debate › Research
- Published
Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuity
Sandhu, M., Cho, A., Ma, N., Mukhaleva, E., Namkung, Y., Lee, S., Ghosh, S., Lee, J. H., Gloriam, David E., Laporte, S. A., Babu, M. M. & Vaidehi, N., 2022, In: Nature Communications. 13, 1, 14 p., 7428.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of β-Arrestin-Biased 25CN-NBOH-Derived 5-HT2A Receptor Agonists
Poulie, Christian Bernard Matthijs, Pottie, E., Simon, Icaro A, Harpsøe, Kasper, D'Andrea, L., Komarov, I. V., Gloriam, David E., Jensen, Anders A., Stove, C. P. & Kristensen, Jesper Langgaard, 2022, In: Journal of Medicinal Chemistry. 65, 18, p. 12031–12043Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABAA receptors
Falk-Petersen, C. B., Tsonkov, T. M., Nielsen, M. S., Harpsøe, Kasper, Bundgaard, C., Frølund, Bente, Kristiansen, Uffe, Gloriam, David E. & Wellendorph, Petrine, 22 Jun 2020, In: Scientific Reports. 10, 1, 12 p., 10078.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors
Foster, S. R., Hauser, Alexander Sebastian, Vedel, L., Strachan, R. T., Huang, X., Gavin, A. C., Shah, S. D., Nayak, A. P., Haugaard-Kedström, L. M., Penn, R. B., Roth, B. L., Bräuner, Hans & Gloriam, David E., 31 Oct 2019, In: Cell. 179, 4, p. 895-908Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of 2-(Imidazo[1,2-b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites
Krall, J., Bavo, Francesco, Falk-Petersen, C. B., Jensen, C. H., Nielsen, J. O., Tian, Yongsong, Anglani, V., Kongstad, Kenneth Thermann, Petersen, Louise Piilgaard, Nielsen, Birgitte, Gloriam, David E., Kehler, J., Jensen, Anders A., Harpsøe, Kasper, Wellendorph, Petrine & Frølund, Bente, 14 Mar 2019, In: Journal of Medicinal Chemistry. 62, 5, p. 2798-2813Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists
Zhang, X., Belousoff, M. J., Zhao, P., Kooistra, A. J., Truong, T. T., Ang, S. Y., Underwood, C. R., Egebjerg, T., Šenel, P., Stewart, G. D., Liang, Y-L., Glukhova, A., Venugopal, H., Christopoulos, A., Furness, S. G. B., Miller, L. J., Reedtz-Runge, S., Langmead, C. J., Gloriam, D. E., Danev, R. & 2 others, , 2020, In: Molecular Cell. 80, 3, p. 485-500Research output: Contribution to journal › Journal article › Research › peer-review
- Accepted/In press
Differential G protein activation by the long and short isoforms of the dopamine D2 receptor
Reiner-Link, David, Madsen, Jakob Sture, Gloriam, David E., Bräuner, Hans & Hauser, Alexander Sebastian, 2024, (Accepted/In press) In: British Journal of Pharmacology.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide
Di Giglio, M. G., Muttenthaler, M., Harpsøe, Kasper, Liutkeviciute, Z., Keov, P., Eder, T., Rattei, T., Arrowsmith, S., Wray, S., Marek, A., Elbert, T., Alewood, P. F., Gloriam, David E. & Gruber, C. W., 1 Feb 2017, In: Scientific Reports. 7, 15 p., 41002.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties
Jensen, Anders A., Plath, N., Pedersen, M. H. F., Isberg, V., Krall, J., Wellendorph, Petrine, Stensbøl, T. B., Gloriam, David E., Krogsgaard-Larsen, Povl & Frølund, Bente, 14 Feb 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 1211-27 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Delineation of molecular determinants for FR900359 inhibition of Gq/11 unlocks inhibition of Gαs
Boesgaard, M. W., Harpsøe, Kasper, Malmberg, M., Underwood, C. R., Inoue, A., Mathiesen, Jesper M., König, G. M., Kostenis, E., Gloriam, David E. & Bräuner, Hans, 2020, In: Journal of Biological Chemistry. 295, 40, p. 13850-13861Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Definition of the G protein-coupled receptor transmembrane bundle binding pocket and calculation of receptor similarities for drug design
Gloriam, David E., Foord, S. M., Blaney, F. E. & Garland, S. L., 2009, In: Journal of Medicinal Chemistry. 52, 14, p. 4429-4442Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Critical evaluation of the FANTOM3 non-coding RNA transcripts
Nordström, K. J. V., Mirza, M. A. I., Almén, M. S., Gloriam, David E., Fredriksson, R. & Schiöth, H. B., 2009, In: Genomics. 94, 3, p. 169-176Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat
Babbitt, P. C., Bagos, P. G., Bairoch, A., Bateman, A., Chatonnet, A., Chen, M. J., Craik, D. J., Finn, R. D., Gloriam, D., Haft, D. H., Henrissat, B., Holliday, G. L., Isberg, V., Kaas, Q., Landsman, D., Lenfant, N., Manning, G., Nagano, N., Srinivasan, N., O’Donovan, C. & 9 others, , 18 May 2015, In: Database: The Journal of Biological Databases and Curation. 2015, p. 1-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Computer-aided discovery of aromatic L-α-amino acids as agonists of the orphan G protein-coupled receptor GPR139
Ísberg, V., Andersen, K. B., Bisig, C., Dietz, G. P., Bräuner, Hans & Gloriam, David E., 14 May 2014, In: Journal of Chemical Information and Modeling. 54, 6, p. 1553-1557 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse
Bjarnadóttir, T. K., Gloriam, David E., Hellstrand, S. H., Kristiansson, H., Fredriksson, R. & Schiöth, H. B., Sep 2006, In: Genomics. 88, 3, p. 263-73 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comprehensive comparisons of the current human, mouse, and rat RefSeq, Ensembl, EST, and FANTOM3 datasets: identification of new human genes with specific tissue expression profile
Nordström, K. J. V., Mirza, M. A. I., Larsson, T. P., Gloriam, David E., Fredriksson, R. & Schiöth, H. B., 29 Sep 2006, In: Biochemical and Biophysical Research Communications. 348, 3, p. 1063-74 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comprehensive Peptide Cyclization Examination Yields Optimized APP Scaffolds with Improved Affinity toward Mint2
Bartling, Christian Reinhard Otto, Alexopoulou, Flora, Kuschert, S., Chin, Y. K. Y., Jia, X., Sereikaité, Vita, Özcelik, D., Jensen, T. M., Jain, P., Nygaard, M. M., Harpsøe, Kasper, Gloriam, David E., Mobli, M. & Strømgaard, Kristian, 2023, In: Journal of Medicinal Chemistry. 66, 4, p. 3045-3057Research output: Contribution to journal › Journal article › Research › peer-review
ID: 5953796
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Kemogenomik: Receptoren set fra lægemiddelstoffets synspunkt
Research output: Contribution to journal › Journal article › Research
Published -
928
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Generic GPCR residue numbers - aligning topology maps while minding the gaps
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
561
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Pharmacogenomics of GPCR Drug Targets
Research output: Contribution to journal › Journal article › Research › peer-review
Published