Anders Bach

Anders Bach

Professor


  1. Published

    Small-molecule modulators of tumor necrosis factor signaling

    Chédotal, H., Narayanan, Dilip, Povlsen, K., Gotfredsen, C. H., Brambilla, R., Gajhede, Michael, Bach, Anders & Clausen, M. H., 2023, In: Drug Discovery Today. 28, 6, 103575.

    Research output: Contribution to journalReviewResearchpeer-review

  2. Published

    Molecular architecture of the Jumonji C family histone demethylase KDM5B

    Dorosz, J., Kristensen, L. H., Aduri, N. G., Mirza, Osman Asghar, Lousen, R., Bucciarelli, S., Mehta, V., Sellés Baiget, Selene, Solbak, Sara Marie Øie, Bach, Anders, Mesa, Pablo, Hernandez, P. A., Montoya, Guillermo, Nguyen, T. T. T. N., Rand, Kasper Dyrberg, Boesen, T. & Gajhede, Michael, 2019, In: Scientific Reports. 9, 13 p., 4019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Rigidified Clicked Dimeric Ligands for Studying the Dynamics of the PDZ1-2 Supramodule of PSD-95

    Eildal, J. N. N., Bach, Anders, Dogan, J., Ye, F., Zhang, M., Jemth, P. & Strømgaard, Kristian, 2015, In: ChemBioChem. 16, p. 64–69 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published
  5. Published

    Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy

    Fiorentini, M., Bach, Anders, Strømgaard, Kristian, Kastrup, Jette Sandholm Jensen & Gajhede, Michael, Apr 2013, In: Acta Crystallographica. Section D: Biological Crystallography. 69, Pt 4, p. 587-94 8 p.

    Research output: Contribution to journalJournal articleResearch

  6. Published

    Detecting protein-protein interactions in living cells: development of a bioluminescence resonance energy transfer assay to evaluate the PSD-95/NMDA receptor interaction

    Gottschalk, M., Bach, Anders, Hansen, J. L., Krogsgaard-Larsen, Povl, Kristensen, Anders Skov & Strømgaard, Kristian, 2009, In: Neurochemical Research. 34, 10, p. 1729-1737

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Selective release of gastrointestinal hormones induced by an orally active GPR39 agonist

    Grunddal, K. V., Diep, T. A., Petersen, N., Tough, I. R., Skov, Louise Julie, Liu, L., Buijink, J. A., Mende, F., Jin, C., Jepsen, Sara Lind, Sørensen, L. M. E., Achiam, Michael Patrick, Strandby, R. B., Bach, Anders, Hartmann, Bolette, Frimurer, Thomas Michael, Hjorth, Siv Annegrethe, Bouvier, M., Cox, H. & Holst, Birgitte, 2021, In: Molecular Metabolism. 49, 14 p., 101207.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Side-chain interactions form late and cooperatively in the binding reaction between disordered peptides and PDZ domains

    Haq, S. R., Chi, C. N., Bach, Anders, Dogan, J., Engström, Å., Hultqvist, G., Karlsson, O. A., Lundström, P., Montemiglio, L. C., Strømgaard, Kristian, Gianni, S. & Jemth, P., Jan 2012, In: Journal of the American Chemical Society. 134, 1, p. 599-605

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling

    Holst, Birgitte, Brandt, E., Bach, Anders, Heding, A. & Schwartz, Thue W., 2005, In: Molecular Endocrinology. 19, 9, p. 2400-11 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Ghrelin receptor inverse agonists: identification of an active peptide core and its interaction epitopes on the receptor

    Holst, Birgitte, Lang, M., Brandt, E., Bach, Anders, Howard, A., Frimurer, T. M., Beck-Sickinger, A. & Schwartz, Thue W., 2006, In: Molecular Pharmacology. 70, 3, p. 936-46 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Common structural basis for constitutive activity of the ghrelin receptor family

    Holst, Birgitte, Holliday, N. D., Bach, Anders, Elling, C. E., Cox, H. M. & Schwartz, Thue W., 2004, In: Journal of Biological Chemistry. 279, 51, p. 53806-17 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors

    Holst, Birgitte, Nygaard, R., Hansen, L. V., Bach, Anders, Engelstoft, M. S., Petersen, P. S., Frimurer, T. M. & Schwartz, Thue W., 2010, In: Journal of Biological Chemistry. 285, 6, p. 3973-85 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Energetic pathway sampling in a protein interaction domain

    Hultqvist, G., Haq, S. R., Punekar, A. S., Chi, C. N., Engström, A., Bach, Anders, Strømgaard, Kristian, Selmer, M., Gianni, S. & Jemth, P., 25 Jun 2013, In: Structure. 21, 7, p. 1193-1202

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    The dynamics of linear polyubiquitin

    Jussupow, A., Messias, A. C., Stehle, R., Geerlof, A., Solbak, Sara Marie Øie, Paissoni, C., Bach, Anders, Sattler, M. & Camilloni, C., Oct 2020, In: Science Advances. 6, 42, 13 p., eabc3786.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood-Brain Barrier Adherence, Uptake, and Permeation

    Kristensen, Mie, Kucharz, Krzysztof, Alves Fernandes, Eduardo Felipe, Strømgaard, Kristian, Schallburg Nielsen, M., Cederberg Helms, H. C., Bach, Anders, Ulrikkaholm Tofte-Hansen, M., Aldana, Blanca, Lauritzen, Martin & Larsen, Birger Brodin, 2020, In: Pharmaceutics. 12, 7, 24 p., 661.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    PSD-95 uncoupling from NMDA receptors by Tat-N-dimer ameliorates neuronal depolarization in cortical spreading depression

    Kucharz, Krzysztof, Søndergaard Rasmussen, I., Bach, Anders, Strømgaard, Kristian & Lauritzen, Martin, 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 5, p. 1820-1828

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published
  18. Published

    Identification and Optimization of Novel Small-Molecule Cas9 Inhibitors by Cell-Based High-Throughput Screening

    Lee, S., Tran, K. T., Vazquez-Uribe, R., Gotfredsen, C. H., Clausen, M. H., Mendez, B. L., Montoya, Guillermo, Bach, Anders & Sommer, M. O. A., 2022, In: Journal of Medicinal Chemistry. 65, 4, p. 3266–3305

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain

    Leurs, U., Klein, A. B., McSpadden, E. D., Griem-Krey, N., Solbak, S. M. Ø., Houlton, J., Villumsen, I. S., Vogensen, S. B., Hamborg, L., Gauger, S. J., Palmelund, L. B., Larsen, A. S. G., Shehata, M. A., Kelstrup, C. D., Olsen, J. V., Bach, A., Burnie, R. O., Kerr, D. S., Gowing, E. K., Teurlings, S. M. W. & 9 others, Chi, C. C., Gee, C. L., Frølund, Bente, Kornum, Birgitte Rahbek, van Woerden, G. M., Clausen, Rasmus Prætorius, Kuriyan, J., Clarkson, A. N. & Wellendorph, Petrine, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 31, 9 p., e2108079118.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    The Cell-Penetrating Peptide Tat Facilitates Effective Internalization of PSD-95 Inhibitors Into Blood–Brain Barrier Endothelial Cells but less Efficient Permeation Across the Blood–Brain Barrier In Vitro and In Vivo

    Lisa Al Humaidan, E., Lund Pedersen, S., Burkhart, A., Laurfelt Munch Rasmussen, C., Moos, T., Fuchs, P., Alves Fernandes, E. F., Ozgür, Burak, Strømgaard, K., Bach, Anders, Larsen, Birger Brodin & Kristensen, Mie, 2022, In: Frontiers in Drug Delivery - CNS Drug Delivery. 2, 17 p., 854703.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    PDZ domain-mediated interactions of G protein-coupled receptors with postsynaptic density protein 95: quantitative characterization of interactions

    Møller, T. C., Wirth, V. F., Roberts, N. I., Bender, J., Bach, Anders, Jacky, B. P. S., Strømgaard, Kristian, Deussing, J. M., Schwartz, Thue W. & Martinez, Karen Laurence, 2013, In: PLOS ONE. 8, 5, e63352.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery

    Narayanan, Dilip, Tran, K. T., Pallesen, J. S., Solbak, S. M. Ø., Qin, Y., Mukminova, E., Luchini, M., Vasilyeva, K. O., González Chichón, D., Goutsiou, G., Poulsen, C., Haapanen, N., Popowicz, G. M., Sattler, M., Olagnier, D., Gajhede, Michael & Bach, Anders, 2022, In: Journal of Medicinal Chemistry. 65, 21, p. 14481-14526

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Targeting Protein-Protein Interactions with Trimeric Ligands: High Affinity Inhibitors of the MAGUK Protein Family

    Nissen, K. B., Kedström, L. M. H., Wilbek, T. S., Nielsen, L. S., Åberg, E., Kristensen, Anders Skov, Bach, Anders, Jemth, P. & Strømgaard, Kristian, 2015, In: PLOS ONE. 10, 2, p. 1-17 17 p., e0117668.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Design, Synthesis, and Characterization of Fatty Acid Derivatives of a Dimeric Peptide-Based Postsynaptic Density-95 (PSD-95) Inhibitor

    Nissen, K. B., Andersen, J. J., Haugaard-Kedström, L. M., Bach, Anders & Strømgaard, Kristian, 2015, In: Journal of Medicinal Chemistry. 58, p. 1575-1580 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Non-covalent Small-Molecule Kelch-like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Inhibitors and Their Potential for Targeting Central Nervous System Diseases

    Pallesen, J. S., Tran, K. T. & Bach, Anders, 27 Sep 2018, In: Journal of Medicinal Chemistry. 61, 18, p. 8088-8103

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 1304261