Bente Frølund
Professor
Medicinal Chemistry
Jagtvej 162
2100 København Ø
- 2023
- Published
Structural and stereochemical determinants for hGAT3 inhibition: development of novel conformationally constrained and substituted analogs of (S)-isoserine
Bavo, Francesco, Kickinger, Stefanie, Lie, M. E. K., Avgerinos, Christos, Wilhelmsen, Kristine Sloth, Wellendorph, Petrine & Frølund, Bente, 2023, In: Medicinal Chemistry Research. 32, p. 2299–2324Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CaMK2 modulators and their use in medicine
Frølund, Bente, Shehata, M. A., Wellendorph, Petrine, Gauger, Stine Juul, Kuriyan, J., McSpadden, E. D., Poulsen, Lasse Brokmose, Fougiaxis, V. & Daraj, K., 2023, IPC No. A61K31/4164, A61K31/4178, A61P25/00, C07D277/06, C07D277/12, C07D277/56, C07D417/04, C07D417/10, Patent No. WO2023170024A1, 1 Jan 1970, Priority No. US202263318852PResearch output: Patent
- Published
Pregnenolone sulfate analogues differentially modulate GABAA receptor closed/desensitised states
Mortensen, M., Xu, Y., Shehata, M. A., Krall, J., Ernst, M., Frølund, Bente & Smart, T. G., 2023, In: British Journal of Pharmacology. 180, 19, p. 2482-2499Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Muscimol inhibits plasma membrane rupture and ninjurin-1 oligomerization during pyroptosis
den Hartigh, A. B., Loomis, W. P., Anderson, M. J., Frølund, Bente & Fink, S. L., 2023, In: Communications Biology . 6, 1, 1010.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
The CaMKIIα hub ligand Ph-HTBA promotes neuroprotection after focal ischemic stroke by a distinct molecular interaction
Griem-Krey, Nane, Gauger, Stine Juul, Gowing, E. K., Thiesen, L., Frølund, Bente, Clarkson, A. N. & Wellendorph, Petrine, 2022, In: Biomedicine and Pharmacotherapy. 156, 10 p., 113895.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery and Optimization of 5-Hydroxy-Diclofenac toward a New Class of Ligands with Nanomolar Affinity for the CaMKIIα Hub Domain
Tian, Yongsong, Shehata, M. A., Gauger, Stine Juul, Ng, C. K. L., Solbak, Sara Marie Øie, Thiesen, L., Bruus-Jensen, J., Krall, J., Bundgaard, C., Gibson, K. M., Wellendorph, Petrine & Frølund, Bente, 2022, In: Journal of Medicinal Chemistry. 65, 9, p. 6656-6676Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exploring the NCS-382 Scaffold for CaMKII alpha Modulation: Synthesis, Biochemical Pharmacology, and Biophysical Characterization of Ph-HTBA as a Novel High-Affinity Brain-Penetrant Stabilizer of the CaMKII alpha Hub Domain
Tian, Yongsong, Shehata, M. A., Gauger, Stine Juul, Veronesi, C., Hamborg, L., Thiesen, L., Bruus-Jensen, J., Royssen, J. S., Leurs, U., Larsen, A. S. G., Krall, J., Solbak, Sara Marie Øie, Wellendorph, Petrine & Frølund, Bente, 2022, In: Journal of Medicinal Chemistry. 65, 22, p. 15066–15084Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Structure-Activity Studies of 3,9-Diazaspiro[5.5]undecane-Based ?-Aminobutyric Acid Type A Receptor Antagonists with Immunomodulatory Effect
Bavo, Francesco, De-Jong, H., Petersen, Jonas Odgaard, Falk-Petersen, C. B., Löffler, R., Sparrow, E., Rostrup, F., Eliasen, Jannik Nicklas, Wilhelmsen, K. S., Barslund, K., Bundgaard, C., Nielsen, Birgitte, Kristiansen, Uffe, Wellendorph, Petrine, Bogdanov, Y. & Frølund, Bente, 2021, In: Journal of Medicinal Chemistry. 64, 24, p. 17795-17812Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular Determinants underlying Delta Selective Compound 2 (DS2) Activity at δ-Containing GABAA Receptors
Falk-Petersen, C. B., Rostrup, F., Löffler, R., Buchleihtner, S., Harpsøe, Kasper, Gloriam, David E., Frølund, Bente & Wellendorph, Petrine, 2021, In: Molecular Pharmacology. 100, 1, p. 46-56Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Radiolabeled HOCPCA as a highly useful tool in drug discovery and pharmacology
Griem-Krey, Nane, Frølund, Bente, Marek, A. & Wellendorph, Petrine, 2021, In: Journal of Labelled Compounds and Radiopharmaceuticals. 64, 2, 77 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular Determinants and Pharmacological Analysis for a Class of Competitive Non-transported Bicyclic Inhibitors of the Betaine/GABA Transporter BGT1
Kickinger, Stefanie, Lie, M. E. K., Suemasa, A., Al-Khawaja, A., Fujiwara, K., Watanabe, M., Wilhelmsen, K. S., Falk-Petersen, C. B., Frølund, Bente, Shuto, S., Ecker, G. F. & Wellendorph, Petrine, 2021, In: Frontiers in Chemistry. 9, 13 p., 736457.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain
Leurs, U., Klein, A. B., McSpadden, E. D., Griem-Krey, N., Solbak, S. M. Ø., Houlton, J., Villumsen, I. S., Vogensen, S. B., Hamborg, L., Gauger, S. J., Palmelund, L. B., Larsen, A. S. G., Shehata, M. A., Kelstrup, C. D., Olsen, J. V., Bach, A., Burnie, R. O., Kerr, D. S., Gowing, E. K., Teurlings, S. M. W. & 9 others, , 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 31, 9 p., e2108079118.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural Determinants for the Mode of Action of Imidazopyridine DS2 at δ-Containing γ-Aminobutyric Acid Type A Receptors
Rostrup, F., Falk-petersen, C. B., Harpsøe, Kasper, Buchleithner, S., Conforti, I., Jung, S., Gloriam, David E., Schirmeister, T., Wellendorph, Petrine & Frølund, Bente, 22 Apr 2021, In: Journal of Medicinal Chemistry. 64, 8, p. 4730-4743 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Silencing of spontaneous activity at α4β1/3δ GABAA receptors in hippocampal granule cells reveals different ligand pharmacology
Dalby, N. O., Falk-Petersen, C. B., Leurs, U., Scholze, P., Krall, J., Frølund, Bente & Wellendorph, Petrine, 2020, In: British Journal of Pharmacology. 177, 17, p. 3975-3990Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sex-specific alterations in GABA receptor-mediated responses in laterodorsal tegmentum (LDT) are associated with prenatal exposure to nicotine
Eliasen, Jannik Nicklas, Krall, J., Frølund, Bente & Kohlmeier, Kristi Anne, 2020, In: Developmental Neurobiology. 80, 5-6, p. 178-199Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABAA receptors
Falk-Petersen, C. B., Tsonkov, T. M., Nielsen, M. S., Harpsøe, Kasper, Bundgaard, C., Frølund, Bente, Kristiansen, Uffe, Gloriam, David E. & Wellendorph, Petrine, 22 Jun 2020, In: Scientific Reports. 10, 1, 12 p., 10078.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A CLASS OF SMALL-MOLECULE COMPOUNDS AND THEIR PRODRUGS FOR INTERVENTION WITH CAMK2A, AND THEIR USE IN ACUTE BRAIN INJURIES AND CENTRAL HYPERSOMNIAS
Frølund, Bente, Wellendorph, Petrine & Kornum, Birgitte Rahbek, 2020, Patent No. WO2020151795, 30 Jul 2020, Priority date 21 Jan 2019, Priority No. DK2019PA70040 20190121Research output: Patent
- Published
Exploring the molecular determinants for subtype-selectivity of 2-amino-1,4,5,6-tetrahydropyrimidine-5-carboxylic acid analogs as betaine/GABA transporter 1 (BGT1) substrate-inhibitors
Kickinger, S., Al-Khawaja, A., Haugaard, A. S., Lie, M. E. K., Bavo, Francesco, Loeffler, R., Damgaard, M., Ecker, G. F., Frølund, Bente & Wellendorph, Petrine, 2020, In: Scientific Reports. 10, 1, 15 p., 12992.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Unraveling the Molecular Determinants for GABA Transporter Subtype Selectivity
Kickinger, S., Al-Khawaja, A., Haugaard, A. S., Lie, M. E. K., Bavo, Francesco, Loffler, R., Damgaard, M., Frølund, Bente, Ecker, G. F. & Wellendorph, Petrine, 2020, p. 130A-130A.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Compounds for the treatment of acute brain injury
Klein, A. B., Leurs, U., Houlton, J., Clausen, Rasmus Prætorius, Frølund, Bente, Clarkson, A. & Wellendorph, Petrine, 2020, Patent No. CN111989094, 24 Nov 2020, Priority date 1 Feb 2019, Priority No. PCT/DK2019/050041Research output: Patent
- Published
TREATMENT OF CNS DISORDERS WITH SLEEP DISTURBANCES
Wellendorph, Petrine, Kornum, Birgitte Rahbek & Frølund, Bente, 2020, Patent No. WO2020259787 , 30 Dec 2020, Priority date 28 Jun 2019, Priority No. DK2019PA70415 20190628Research output: Patent
- 2019
- Published
Five-membered N-heterocyclic Scaffolds as Novel Amino Bioisosteres at gamma-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters
Giraudo, A., Krall, J., Bavo, Francesco, Nielsen, Birgitte, Kongstad, Kenneth Thermann, Rolando, B., De Blasio, R., Gloriam, David E., Löffler, R., Thiesen, L., Harpsøe, Kasper, Frydenvang, Karla Andrea, Boschi, D., Wellendorph, Petrine, Lolli, M. L., Jensen, Anders A. & Frølund, Bente, 27 Jun 2019, In: Journal of Medicinal Chemistry. 62, 12, p. 5797-5809Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural and molecular aspects of betaine-GABA transporter 1 (BGT1) and its relation to brain function
Kickinger, S., Hellsberg, E., Frølund, Bente, Schousboe, Arne, Ecker, G. F. & Wellendorph, Petrine, 2019, In: Neuropharmacology. 161, 14 p., 107644.Research output: Contribution to journal › Review › Research › peer-review
- Published
Discovery of 2-(Imidazo[1,2-b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites
Krall, J., Bavo, Francesco, Falk-Petersen, C. B., Jensen, C. H., Nielsen, J. O., Tian, Yongsong, Anglani, V., Kongstad, Kenneth Thermann, Petersen, Louise Piilgaard, Nielsen, Birgitte, Gloriam, David E., Kehler, J., Jensen, Anders A., Harpsøe, Kasper, Wellendorph, Petrine & Frølund, Bente, 14 Mar 2019, In: Journal of Medicinal Chemistry. 62, 5, p. 2798-2813Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and Pharmacological Evaluation of [C-11]4-Methoxy-N-[2-(thiophen-2-yl) imidazo[1,2-a] pyridin-3-yl]benzamide as a Brain Penetrant PET Ligand Selective for the delta-Subunit-Containing gamma-Aminobutyric Acid Type A Receptors
L'Estrade, E. T., Hansen, H. D., Falk-Petersen, C., Haugaard, A., Griem-Krey, Nane, Jung, S., Lueddens, H., Schirmeister, T., Erlandsson, M., Ohlsson, T., Knudsen, Gitte Moos, Herth, Matthias Manfred, Wellendorph, Petrine & Frølund, Bente, May 2019, In: ACS Omega. 4, 5, p. 8846-8851Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Developing New 4-PIOL and 4-PHP Analogues for Photoinactivation of γ-Aminobutyric Acid Type A Receptors
Mortensen, M., Krall, J., Kongstad, Kenneth Thermann, Brygger, B. M., Lenzi, O., Francotte, P., Sørensen, T. E., Nielsen, Birgitte, Jensen, Anders A., Smart, T. G. & Frølund, Bente, 2019, In: ACS Chemical Neuroscience. 10, 11, p. 4669-4684Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Designing Poly-agonists for Treatment of Metabolic Diseases: Challenges and Opportunities
Petersen, Jonas Odgaard, Strømgaard, Kristian, Frølund, Bente & Clemmensen, Christoffer, 2019, In: Drugs. 79, 11, p. 1187-1197 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lack of evidence for synaptic high-affinity γ-hydroxybutyric acid (GHB) transport in rat brain synaptosomes and 11 Na+ -dependent SLC neurotransmitter transporters
Thiesen, L., Frølund, Bente & Wellendorph, Petrine, Apr 2019, In: Journal of Neurochemistry. 149, 2, p. 195-210 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Pharmacological Characterization of [3H]ATPCA as a Substrate for Studying the Functional Role of the Betaine/GABA Transporter 1 and the Creatine Transporter
Al-Khawaja, A., Haugaard, A. S., Marek, A., Löffler, R., Thiesen, L., Santiveri, M., Damgaard, M., Bundgaard, C., Frølund, Bente & Wellendorph, Petrine, 21 Mar 2018, In: A C S Chemical Neuroscience. 9, 3, p. 545–554Research output: Contribution to journal › Journal article › Research › peer-review
- Published
4-Hydroxy-1,2,3-triazole moiety as bioisostere of the carboxylic acid function: a novel scaffold to probe the orthosteric gamma-aminobutyric acid receptor binding site
Alessandro, G., Krall, J., Nielsen, Birgitte, Sørensen, T. E., Kongstad, Kenneth Thermann, Barbara, R., Donatella, B., Frølund, Bente & Lolli, M. L., 5 Oct 2018, In: European Journal of Medicinal Chemistry. 158, p. 311-321 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis, pharmacological activity and molecular modeling studies of a series of 2-amino-1,4,5,6-tetrahydropyrimidine-5-carboxylic acid analogues as betaine/GABA transporter 1 (BGT1) substrate-inhibitors
Kickinger, S., Al-Khawaja, A., Haugaard, A. S., Loeffler, R., Damgaard, M., Eckert, G., Frølund, Bente & Wellendorph, Petrine, 19 Aug 2018.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Structure-Function Evaluation of Imidazopyridine Derivatives Selective for δ-Subunit-Containing γ-Aminobutyric Acid Type A (GABAA) Receptors
Yakoub, K., Jung, S., Sattler, C., Damerow, H., Weber, J., Kretzschmann, A., Cankaya, A. S., Piel, M., Rösch, F., Haugaard, A. S., Frølund, Bente, Schirmeister, T. & Lüddens, H., 8 Mar 2018, In: Journal of Medicinal Chemistry. 61, 5, p. 1951-1968 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Functional characterization of GABAA receptor-mediated modulation of cortical neuron network activity in microelectrode array recordings
Bader, B. M., Steder, A., Klein, A. B., Frølund, Bente, Schroeder, O. H. U. & Jensen, Anders A., 2017, In: PloS One. 12, 10, 32 p., e0186147.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development of Non-GAT1-Selective Inhibitors: Challenges and Achievements
Damgaard, M., Haugaard, A. S., Kickinger, S., Al-Khawaja, A., Lie, M. E. K., Ecker, G. F., Clausen, Rasmus Prætorius & Frølund, Bente, 2017, Advances in Neurobiology. Springer, Vol. 16. p. 315-332 18 p. (Advances in Neurobiology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Monastrol, a 3,4-dihydropyrimidin-2(1H)-thione, as structural scaffold for the development of modulators for GHB high-affinity binding sites and α1β2δ GABAA receptors
Damgaard, M., Al-Khawaja, A., Nittegaard-Nielsen, M., Petersen, R. F., Wellendorph, Petrine & Frølund, Bente, 15 Jun 2017, In: European Journal of Medicinal Chemistry. 138, p. 300-312 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development of a Robust Mammalian Cell-based Assay for Studying Recombinant α4 β1/3 δ GABAA Receptor Subtypes
Falk-Petersen, C. B., Søgaard, R., Madsen, Kenneth Lindegaard, Klein, A. B., Frølund, Bente & Wellendorph, Petrine, Aug 2017, In: Basic & Clinical Pharmacology & Toxicology. 121, 2, p. 119-129 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Radiosynthesis and Evaluation of [(11)C]3-Hydroxycyclopent-1-enecarboxylic Acid as Potential PET Ligand for the High-Affinity γ-Hydroxybutyric Acid Binding Sites
Jensen, C. H., Hansen, H. D., Bay, T., Vogensen, S. B., Lehel, S., Thiesen, L., Bundgaard, C., Clausen, Rasmus Prætorius, Knudsen, Gitte Moos, Herth, Matthias Manfred, Wellendorph, Petrine & Frølund, Bente, 18 Jan 2017, In: A C S Chemical Neuroscience. 8, 1, p. 22-27 6 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analogs
Krall, J., Jensen, C. H., Bavo, F., Falk-Petersen, C. B., Haugaard, A. S., Vogensen, S. B., Tian, Y., Nittegaard-Nielsen, M., Sigurdardóttir, S. B., Kehler, J., Kongstad, Kenneth Thermann, Gloriam, David E., Clausen, Rasmus Prætorius, Harpsøe, Kasper, Wellendorph, Petrine & Frølund, Bente, 2017, In: Journal of Medicinal Chemistry. 60, 21, p. 9022-9039 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery and Evaluation of Anti-Fibrinolytic Plasmin Inhibitors Derived from 5-(4-Piperidyl)isoxazol-3-ol (4-PIOL)
Schmidt, T. C., Eriksson, P., Gustafsson, D., Cosgrove, D., Frølund, Bente & Boström, J., 24 Jul 2017, In: Journal of Chemical Information and Modeling. 57, 7, p. 1703-1714 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Astrocytic GABA Transporters: Pharmacological Properties and Targets for Antiepileptic Drugs
Schousboe, Arne, Wellendorph, Petrine, Frølund, Bente, Clausen, Rasmus Prætorius & Krogsgaard-Larsen, Povl, 2017, Glial Amino Acid Transporters. Springer, Vol. 16. p. 283-296 14 p. (Advances in Neurobiology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication
- Published
Imidazole-4-acetic acid, a new lead structure for interaction with the taurine transporter in outer blood-retinal barrier cells
Valembois, S. A. N., Krall, J., Frølund, Bente & Steffansen, B., 30 May 2017, In: European Journal of Pharmaceutical Sciences. 103, p. 77-84 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Delineation of the functional properties and the mechanism of action of TMPPAA, an allosteric agonist and positive allosteric modulator of 5-HT3 Receptors
Gasiorek, A., Trattnig, S. M., Ahring, P. K., Kristiansen, Uffe, Frølund, Bente, Frederiksen, K. & Jensen, Anders A., 2016, In: Biochemical Pharmacology. 110-111, p. 92-108 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Autoradiographic imaging and quantification of the high-affinity GHB binding sites in rodent brain using (3)H-HOCPCA
Klein, A. B., Bay, T., Villumsen, I. S., Falk-Petersen, C. B., Marek, A., Frølund, Bente, Clausen, Rasmus Prætorius, Hansen, H. D., Knudsen, Gitte Moos & Wellendorph, Petrine, Nov 2016, In: Neurochemistry International. 100, p. 138-145 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of α-Substituted Imidazole-4-acetic Acid Analogues as a Novel Class of ρ1 γ-Aminobutyric Acid Type A Receptor Antagonists with Effect on Retinal Vascular Tone
Krall, J., Brygger, B. M., Sigurðardóttir, S. B., Ng, C. K. L., Bundgaard, C., Kehler, J., Nielsen, Birgitte, Bek, T., Jensen, Anders A. & Frølund, Bente, 13 Sep 2016, In: ChemMedChem. 11, 20, p. 2299-2310 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The labeling of unsaturated γ-hydroxybutyric acid by heavy isotopes of hydrogen: iridium complex-mediated H/D exchange by C─H bond activation vs reduction by boro-deuterides/tritides
Marek, A., Pedersen, M. H. F., Vogensen, S. B., Clausen, Rasmus Prætorius, Frølund, Bente & Elbert, T., Oct 2016, In: Journal of Labelled Compounds and Radiopharmaceuticals. 59, 12, p. 476-483 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Context-Dependent Modulation of GABAAR-Mediated Tonic Currents
Patel, B., Bright, D. P., Mortensen, M., Frølund, Bente & Smart, T. G., 13 Jan 2016, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 36, 2, p. 607-21 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Exploration of the molecular architecture of the orthosteric binding site in the α4β2 nicotinic acetylcholine receptor with analogs of 3-(dimethylamino)butyl dimethylcarbamate (DMABC) and 1-(pyridin-3-yl)-1,4-diazepane.
Bach, T. B., Jensen, Anders A., Petersen, J. G., Sørensen, T. E., Volpe, S. D., Liu, J., Blaazer, A. R., van Muijlwijk-Koezen, J. E., Balle, T. & Frølund, Bente, 2015, In: European Journal of Medicinal Chemistry. 102, p. 425-444 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of the first highly selective inhibitor of human GABA transporter GAT3
Damgaard, M., Al-Khawaja, A., Vogensen, S. B., Jurik, A., Sijm, M., Lie, M., Bæk, M. I., Rosenthal, E., Jensen, Anders A., Ecker, G. F., Frølund, Bente, Wellendorph, Petrine & Clausen, Rasmus Prætorius, 2015, In: A C S Chemical Neuroscience. 6, p. 1591-1599 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GABAA receptor partial agonists and antagonists: structure, binding mode, and pharmacology
Krall, J., Balle, T., Krogsgaard-Larsen, N., Sørensen, T. E., Krogsgaard-Larsen, Povl, Kristiansen, Uffe & Frølund, Bente, 2015, Diversity and functions of GABA receptors: A tribute to Hanns Möhler, Part A. Vol. 72. p. 201-27 27 p. (Advances in Pharmacology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Differential interactions of 5-(4-piperidyl)-3-isoxazolol analogues with insect γ-aminobutyric acid receptors leading to functional selectivity
Liu, G., Frølund, Bente, Ozoe, F. & Ozoe, Y., 2015, In: Insect Biochemistry and Molecular Biology. 66, p. 64-71 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Substituted 4-hydroxy-1,2,3-triazoles: synthesis, characterization and first drug design applications through bioisosteric modulation and scaffold hopping approaches
Pippione, A. C., Dosio, F., Ducime, A., Federico, A., Martina, K., Sainas, S., Frølund, Bente, Gooyit, M., Janda, K. D., Boschi, D. & Lolli, M. L., 1 Jul 2015, In: MedChemComm. 6, 7, p. 1285-1292 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In vitro and in vivo evidence for active brain uptake of the GHB analogue HOCPCA by the monocarboxylate transporter subtype 1
Thiesen, L., Kehler, J., Clausen, Rasmus Prætorius, Frølund, Bente, Bundgaard, C. & Wellendorph, Petrine, 2015, In: Journal of Pharmacology and Experimental Therapeutics. 354, 2, p. 166-174 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformationally restrained carbamoylcholine homologues. Synthesis, pharmacology at neuronal nicotinic acetylcholine receptors and biostructural considerations
de la Fuente Revenga, M., Balle, T., Jensen, Anders A. & Frølund, Bente, 2015, In: European Journal of Medicinal Chemistry. 102, p. 352-362 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
Pharmacological Identification of a Guanidine-Containing β-Alanine Analogue with Low Micromolar Potency and Selectivity for the Betaine/GABA Transporter 1 (BGT1)
Al-Khawaja, A. M. A., Petersen, J. G., Damgaard, M., Jensen, M. H., Vogensen, S. B., Lie, M. E. K., Kragholm, B., Bräuner, Hans, Clausen, Rasmus Prætorius, Frølund, Bente & Wellendorph, Petrine, 23 May 2014, In: Neurochemical Research. 39, 10, p. 1988-1996 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The GABAA Antagonist DPP-4-PIOL Selectively Antagonises Tonic over Phasic GABAergic Currents in Dentate Gyrus Granule Cells
Boddum, K., Frølund, Bente & Kristiansen, Uffe, 8 Aug 2014, In: Neurochemical Research. 39, 11, p. 2078–2084 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Positive allosteric modulation of the GHB high-affinity binding site by the GABAA receptor modulator monastrol and the flavonoid catechin
Eghorn, L. F., Høstgaard-Jensen, K., Kongstad, Kenneth Thermann, Bay, T., Higgins, D., Frølund, Bente & Wellendorph, Petrine, 5 Oct 2014, In: European Journal of Pharmacology. 740, p. 570-577 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Probing α4βδ GABAA Receptor Heterogeneity: Differential Regional Effects of a Functionally Selective α4β1δ/α4β3δ Receptor Agonist on Tonic and Phasic Inhibition in Rat Brain
Hoestgaard-Jensen, K., Dalby, N. O., Krall, J., Hammer, H., Krogsgaard-Larsen, Povl, Frølund, Bente & Jensen, Anders A., 2014, In: Journal of Neuroscience. 34, 49, p. 16256-16272 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
5-(Piperidin-4-yl)-3-Hydroxypyrazole: A Novel Scaffold for Probing the Orthosteric γ-Aminobutyric Acid Type A Receptor Binding Site
Krall, J., Kongstad, Kenneth Thermann, Nielsen, Birgitte, Sørensen, T. E., Balle, T., Jensen, Anders A. & Frølund, Bente, 2014, In: ChemMedChem. 9, 11, p. 2475-2485 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and pharmacological evaluation of 6-aminonicotinic acid analogues as novel γ-aminobutyric acidA receptor agonists
Petersen, J. G., Sørensen, T. E., Damgaard, M., Nielsen, Birgitte, Jensen, Anders A., Balle, T., Bergmann, R. & Frølund, Bente, 2014, In: European Journal of Medicinal Chemistry. 84, p. 404-416 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
GABAergic control of arteriolar diameter in the rat retina
Hinds, K., Monaghan, K. P., Frølund, Bente, McGeown, J. G. & Curtis, T. M., 2013, In: Invest. Ophthalmol. Vis. Sci.. 54, 10, p. 6798–6805Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The orthosteric GABAA receptor ligand Thio-4-PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors
Hoestgaard-Jensen, K., O'Connor, R. M., Dalby, N. O., Simonsen, C., Finger, B. C., Golubeva, A., Hammer, H., Bergmann, M. L., Kristiansen, Uffe, Krogsgaard-Larsen, Povl, Bräuner, Hans, Ebert, B., Frølund, Bente, Cryan, J. F. & Jensen, Anders A., Oct 2013, In: British Journal of Pharmacology. 170, 4, p. 919-32 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties
Jensen, Anders A., Plath, N., Pedersen, M. H. F., Isberg, V., Krall, J., Wellendorph, Petrine, Stensbøl, T. B., Gloriam, David E., Krogsgaard-Larsen, Povl & Frølund, Bente, 14 Feb 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 1211-27 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exploring the orthosteric binding site of the γ-aminobutyric acid type A receptor using 4-(piperidin-4-yl)-1-hydroxypyrazoles 3- or 5-imidazolyl substituted: design, synthesis, and pharmacological evaluation
Krall, J., Jensen, C. H., Sørensen, T. E., Nielsen, Birgitte, Jensen, Anders A., Sander, T., Balle, T. & Frølund, Bente, 15 Jul 2013, In: Journal of Medicinal Chemistry. 56, 16, p. 6536−6540 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Probing the orthosteric binding site of GABAA receptors with heterocyclic GABA carboxylic acid bioisosteres
Petersen, J. G., Bergmann, R., Krogsgaard-Larsen, Povl, Balle, T. & Frølund, Bente, 21 Dec 2013, In: Neurochemical Research. 39, p. 1005-1015Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as ¿-aminobutyric acidA receptor agonists
Petersen, J. G., Bergmann, R., Møller, H. A., Jørgensen, Charlotte Grube, Nielsen, Birgitte, Kehler, J., Frydenvang, Karla Andrea, Kristensen, Jesper Langgaard, Balle, T., Jensen, Anders A., Kristiansen, Uffe & Frølund, Bente, 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 993-1006Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis, pharmacology and biostructural characterization of novel a4ß2 nicotinic acetylcholine receptor agonists
Ussing, C. A., Hansen, C. P., Petersen, J. G., Jensen, Anders A., Rohde, L. A. H., Ahring, P. K., Nielsen, E. Ø., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Frølund, Bente & Balle, T., 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 940-951Research output: Contribution to journal › Journal article › Research › peer-review
- Published
New synthesis and tritium labeling of a selective ligand for studying high-affinity γ-hydroxybutyrate (GHB) binding sites
Vogensen, S. B., Marek, A., Bay, T., Wellendorph, Petrine, Kehler, J., Bundgaard, C., Frølund, Bente, Pedersen, M. H. F. & Clausen, Rasmus Prætorius, 2013, In: Journal of Medicinal Chemistry. 56, 20, p. 8201–8205Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
α4βδ GABA receptors are high-affinity targets for γ-hydroxybutyric acid (GHB)
Absalom, N., Karim, N., Eghorn, L. F., Villumsen, I. S., Bay, T., Bräuner, Hans, Frølund, Bente, Clausen, Rasmus Prætorius, Olsen, Jesper Velgaard, Knudsen, Gitte Moos, Chebib, M. & Wellendorph, Petrine, 14 Aug 2012, In: Proceedings of the National Academy of Sciences USA (PNAS). 109, 33, p. 13404-13409 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
5-(Piperidine-4-yl)-3-hydroxypyrazole: a novel scaffold forprobing the orthosteric GABAA receptor binding site
Krall, J., Kongstad, Kenneth Thermann, Balle, T., Nielsen, Birgitte, Jensen, A. A. & Frølund, Bente, 2 Sep 2012.Research output: Contribution to conference › Poster › Research
- 2011
- Published
Discovery of benzamide analogues as a novel class of 5-HT3 receptor agonists
Jørgensen, Charlotte Grube, Frølund, Bente, Kehler, J. & Jensen, Anders A., 4 Apr 2011, In: ChemMedChem. 6, 4, p. 725-736Research output: Contribution to journal › Journal article › Research › peer-review
- Published
New insights into the GABAA receptor structure and orthosteric ligand binding: Receptor modeling guided by experimental data
Sander, T., Frølund, Bente, Bruun, A. T., Ivanov, I., McCammon, J. A. & Balle, T., May 2011, In: Proteins: Structure, Function, and Bioinformatics. 79, 5, p. 1458-1477Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Målrettet fisketur i hjernen giver ny viden om Fantasys virkningssted
Villumsen, I. S., Vogensen, S. B., Frølund, Bente, Clausen, Rasmus Prætorius & Wellendorph, Petrine, Dec 2011, In: Lægemiddelforskning. 2011, p. 26-28Research output: Contribution to journal › Journal article › Communication
- Published
Målrettet fisketur i hjernen giver ny viden om Fantasy’s virkningssted
Villumsen, I. S., Vogensen, S. B., Frølund, Bente, Clausen, Rasmus Prætorius & Wellendorph, Petrine, 2011, In: Lægemiddelforskning. 2011, p. 26-28Research output: Contribution to journal › Journal article › Communication
- Published
Potentiating action of propofol at GABAA receptors of retinal bipolar cells
Yue, L., Xie, A., Bruzik, K. S., Frølund, Bente, Qian, H. & Pepperberg, D. R., 1 Jan 2011, In: Investigative Ophthalmology & Visual Science. 52, 5, p. 2497-2509Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
GABA and glutamic acid receptor ligands
Frølund, Bente & Madsen, Ulf, 2010, Textbook of drug design and discovery. Krogsgaard-Larsen, P., Strømgaard, K. & Madsen, U. (eds.). 4 ed. Boca Raton: CRC Press, p. 239-262Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
- Published
Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as gamma-aminobutyric acidA receptor ligands: synthesis, pharmacology, and structure-activity relationships
Møller, H. A., Sander, T., Kristensen, Jesper Langgaard, Nielsen, Birgitte, Krall, J., Bergmann, M. L., Christiansen, B., Balle, T., Jensen, Anders A. & Frølund, Bente, 2010, In: Journal of Medicinal Chemistry. 53, 8, p. 3417-3421Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design, synthesis, and in vitro pharmacology of new radiolabeled ¿-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity ¿-hydroxybutyric acid binding sites
Sabbatini, P., Wellendorph, Petrine, Høg, S., Pedersen, M. H. F., Bräuner, Hans, Martiny, L., Frølund, Bente & Clausen, Rasmus Prætorius, 2010, In: Journal of Medicinal Chemistry. 53, 17, p. 6506-6510Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel radioiodinated γ-hydroxybutyric acid analogues for radiolabeling and photolinking of high-affinity γ-hydroxybutyric acid binding sites
Wellendorph, Petrine, Høg, S., Sabbatini, P., Pedersen, M. H. F., Martiny, L., Knudsen, Gitte Moos, Frølund, Bente, Clausen, Rasmus Prætorius & Bräuner, Hans, 2010, In: Journal of Pharmacology and Experimental Therapeutics. 335, 2, p. 458-464Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
Characterization of GABAA receptor ligands in the rat corticalwedge preparation: evidence for action at extrasynaptic receptors?
Ebert, B., Storustovu, S. I., Mortensen, M. S. & Frølund, Bente, 2009, In: British Journal of Pharmacology. 137, 1, p. 1–8Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GABAA-receptoren: Bedre modeller - bedre lægemidler
Frølund, Bente, Sander, T., Hansen, H. & Balle, T., 2009, In: Lægemiddelforskning. p. 31-33Research output: Contribution to journal › Journal article › Communication
- Published
Carbamoylcholine analogs as nicotinic acetylcholine receptor agonists--structural modifications of 3-(dimethylamino)butyl dimethylcarbamate (DMABC)
Hansen, C. P., Jensen, Anders A., Balle, T., Bitsch-Jensen, K., Hassan, M. M., Liljefors, T. & Frølund, Bente, 2009, In: Bioorganic & Medicinal Chemistry Letters. 19, 1, p. 87-91Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
Ligands for the GABA recognition site at the GABAA receptor: Structure-activity studies
Frølund, Bente, Kristiansen, Uffe, Krogsgaard-Larsen, Povl & Liljefors, T., 2008, Chemistry and molecular aspects of drug design and action. Rekka, E. A. & Kourounakis, P. N. (eds.). Boca Raton, Fl: CRC Press, p. 139-147Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Novel acetylcholine and carbamoylcholine analogues: Development of a functionally selective a4ß2 nicotinic acetylcholine receptor agonist
Hansen, C. P., Jensen, Anders A., Christensen, J. K., Balle, T., Liljefors, T. & Frølund, Bente, 2008, In: Journal of Medicinal Chemistry. 51, 23, p. 7380-7395Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel high-affinity and selective biaromatic 4-substituted ¿-hydroxybutyric acid (GHB) analogues as GHB ligands: design, synthesis, and binding studies
Høg, S., Wellendorph, Petrine, Nielsen, Birgitte, Frydenvang, Karla Andrea, Dahl, I. F., Bräuner, Hans, Brehm, L., Frølund, Bente & Clausen, Rasmus Prætorius, 2008, In: Journal of Medicinal Chemistry. 51, 24, p. 8088-8095Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transport of amino acids and GABA analogues via the human proton-coupled amino acid transporter, hPAT1: Characterization of conditions for affinity and transport experiments in Caco-2 cells.
Larsen, M., Larsen, Birger Brodin, Frølund, Bente & Nielsen, C. U., 2008, In: European Journal of Pharmaceutical Sciences. 35, 1-2, p. 86-95Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of the betaine-GABA transporter (mGAT2/BGT-1) modulates spontaneous electrographic bursting in the medial entorhinal cortex (mEC)
Smith, M. D., Saunders, G. W., Clausen, Rasmus Prætorius, Frølund, Bente, Krogsgaard-Larsen, Povl, Larsson, O. M., Schousboe, Arne, Wilcox, K. S. & White, H. S., 2008, In: Epilepsy Research. 79, 1, p. 6-13Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
The human proton-coupled amino acid transporter (hPAT1) is a transport system for GABA-like drugs
Broberg, M. L., Frølund, Bente, Larsen, Birger Brodin & Nielsen, C. U., 2007. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
7-substituted-melatonin and 7-substituted-1-methylmelatonin analogues: Effect of substituents on potency and binding affinity
Faust, R., Garratt, P. J., Pérez, M. A. T., Piccio, V. J., Madsen, C., Stenstrøm, A., Frølund, Bente, Davidson, K., Teh, M. & Sugden, D., 2007, In: Bioorganic & Medicinal Chemistry. 15, 13, p. 4543-4551Research output: Contribution to journal › Journal article › Research › peer-review
- Published
4-aryl-5-(4-piperidyl)-3-isoxazolol GABAA antagonists: synthesis, pharmacology, and structure-activity relationships
Frølund, Bente, Jensen, L. S., Storustovu, S. I., Stensbøl, T. B., Ebert, B., Kehler, J., Krogsgaard-Larsen, Povl & Liljefors, T., 2007, In: Journal of Medicinal Chemistry. 50, 8, p. 1988-1992Research output: Contribution to journal › Journal article › Research › peer-review
- Published
5-substituted imidazole-4-acetic acid analogues: synthesis, modeling, and pharmacological characterization of a series of novel ¿-aminobutyric acidC receptor agonists
Madsen, C., Jensen, A. A., Liljefors, T., Kristiansen, Uffe, Nielsen, Birgitte, Hansen, C. P., Larsen, M., Ebert, B., Bang-Andersen, B., Krogsgaard-Larsen, Povl & Frølund, Bente, 2007, In: Journal of Medicinal Chemistry. 50, 17, p. 4147-4161Research output: Contribution to journal › Journal article › Research › peer-review
- Published
5-Substituted imidazole-4-acetic acid analogues: Synthesis, modeling, and pharmacological characterization of a series of novel γ-aminobutyric acidC receptor agonists
Madsen, C., Jensen, Anders A., Liljefors, T., Kristiansen, Uffe, Nielsen, Birgitte, Hansen, C. P., Larsen, M., Ebert, B., Bang-Andersen, B., Krogsgaard-Larsen, Povl & Frølund, Bente, 2007, In: Journal of Medicinal Chemistry. 50, p. 4147-4161Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional and pharmacological aspects of GABA transporters
Madsen, K., White, H. S., Clausen, Rasmus Prætorius, Frølund, Bente, Larsson, O. M., Krogsgaard-Larsen, Povl & Schousboe, Arne, 2007, Handbook of nerochemistry and molecular neurobiology: Neural membranes and transport. Lajtha, A. & Reith, M. E. A. (eds.). 3rd. ed. Berlin: Springer, Vol. 3. p. 285-304Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Differences in kinetics of structurally related competitive GABAA receptor antagonists
Vestergaard, H. T., Cannillo, C., Frølund, Bente & Kristiansen, Uffe, 2007, In: Neuropharmacology. 52, 3, p. 873-882Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
- Published
Structure-Activity Relationship and Pharmacology of γ-Aminobutyric Acid (GABA) Transport Inhibitors
Clausen, Rasmus Prætorius, Madsen, K., Larsson, O. M., Frølund, Bente, Krogsgaard-Larsen, Povl & Schousboe, Arne, 1 Dec 2006, GABA. Enna, S. J. (ed.). p. 265-284 20 p. (Advances in Pharmacology, Vol. 54).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Structure–Activity Relationship and Pharmacology of γ‐Aminobutyric Acid Transport Inhibitor
Clausen, Rasmus Prætorius, Madsen, K., Larsson, O. M., Frølund, Bente, Krogsgaard-Larsen, Povl & Schousboe, Arne, 2006, GABA. Enna, S. (ed.). Vol. 54. p. 265–284 (Advances in Pharmacology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Synthesis of 3-Hydroxy- and 3-Carboxy-Δ2-isoxazoline Amino Acids and Evaluation of Their Interaction with GABA Receptors and Transporters
Conti, P., De Amici, M., Pinto, A., Tamborini, L., Grazioso, G., Frølund, Bente, Nielsen, Birgitte, Thomsen, C., Ebert, B. & De Michelli, C., 2006, In: European Journal of Pharmacology. p. 5533–5542Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A novel selective γ-aminobutyric acid transport inhibitor demonstrates a functional role for GABA transporter subtype GAT2/BGT-1 in the CNS
Frølund, Bente, Clausen, Rasmus Prætorius, Larsson, O. M., Schousboe, Arne, Krogsgaard-Larsen, Povl & White, H. S., 2006, In: Neurochemistry International. 48, p. 637–642Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effekt og bivirkninger: GABA fra A til C.
Frølund, Bente, Madsen, C., Jensen, Anders A., Kristiansen, Uffe & Liljefors, T., 2006, In: Lægemiddelforskning. p. 32-33Research output: Contribution to journal › Journal article › Communication
- Published
MEDI 480-Novel lipophilic gamma-hydroxybutyrate (GHB) analogs with high affinity to GHB sites in rat brain
Hog, S., Wellendorph, Petrine, Nielsen, Birgitte, Frølund, Bente & Clausen, Rasmus Prætorius, 10 Sep 2006, In: American Chemical Society. Abstracts of Papers (at the National Meeting). 232Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Structure-Activity Relationships of Selective GABA Uptake Inhibitors
Høg, S., Greenwood, J., Madsen, K. B., Larsson, O. M., Frølund, Bente, Schousboe, Arne, Krogsgaard-Larsen, Povl & Clausen, Rasmus Prætorius, 2006, In: Current Topics in Medicinal Chemistry. 6, 17, p. 1861–1882Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Potent 4-Arylalkyl-Substituted 3-Isothiazolol GABAA Competitive/Noncompetitive Antagonists: Synthesis and Pharmacology
Krehan, D., i Storustovu, S., Liljefors, T., Ebert, B., Nielsen, Birgitte, Krogsgaard-Larsen, Povl & Frølund, Bente, 2006, In: Journal of Medicinal Chemistry. 49, p. 1388–1396Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GABAA Agonists and Partial Agonists: THIP (Gaboxadol) as a Non-Opioid Analgesic and a Novel Type of Hypnotic
Krogsgaard-Larsen, Povl, Frølund, Bente, Liljefors, T. & Ebert, B., 2006, GABA. Enna, S. (ed.). p. 53–71 (Advances in Pharmacology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Functional and Pharmacological Aspects of GABA Transporters
Madsen, K., White, S. H., Clausen, Rasmus Prætorius, Larsson, O. M., Frølund, Bente, Krogsgaard-Larsen, Povl & Schousboe, Arne, 2006, Handbook of Neurochemistry and Molecular neurobiology. p. 1-17Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 2005
- Published
Design, synthesis, and characterisation of selective GABA transport inhibitors
Clausen, Rasmus Prætorius, Moltzen, E., Perregaard, J., Lenz, S., Sanchez, S., Frølund, Bente, Bolvig, T., Sarup, A., Larsson, O., White, H., Schousboe, Arne & Krogsgaard-Larsen, Povl, Aug 2005, In: Journal of Neurochemistry. 94, p. 150-150Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Selective inhibitors of GABA uptake: synthesis and molecular pharmacology of 4-N-methylamino- 4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol analogues
Clausen, Rasmus Prætorius, Moltzen, E. K., Perregaard, J., Lenz, S., Sanchez, C., Falch, E., Frølund, Bente, Bolvig, T., Sarup, A., Larsson, O. M., Schousboe, Arne & Krogsgaard-Larsen, Povl, 2005, In: Bioorganic & Medicinal Chemistry. 13, p. 895–908Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Potent 4-Aryl- or 4-Arylalkyl-Substituted 3-Isoxazolol GABAA Antagonists: Synthesis, Pharmacology, and Molecular Modeling
Frølund, Bente, Jensen, L. S., Guandalini, L., Canillo, C., Vestergaard, H. T., Kristiansen, U., Nielsen, Birgitte, Stensbøl, T. B., Madsen, C., Krogsgaard-Larsen, Povl & Liljefors, T., 2005, In: Journal of Medicinal Chemistry. 48, p. 427–439Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABAA antagonists: Synthesis, pharmacology, and molecular modeling
Frølund, Bente, Jensen, L. S., Guandalini, L., Canillo, C., Vestergaard, H. T., Kristiansen, Uffe, Nielsen, Birgitte, Stensbøl, T. B., Madsen, C., Krogsgaard-Larsen, Povl & Liljefors, T., 27 Jan 2005, In: Journal of Medicinal Chemistry. 48, 2, p. 427-439 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tetrazolyl isoxazole amino acids as ionotropic glutamate receptor antagonists: synthesis, modelling and molecular pharmacology
Frølund, Bente, Greenwood, J. R., Holm, M. M., Egebjerg, J., Madsen, Ulf, Nielsen, Birgitte, Bräuner, Hans, Stensbøl, T. B. & Krogsgaard-Larsen, Povl, 15 Sep 2005, In: Bioorganic & Medicinal Chemistry. 13, 18, p. 5391-8Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations
Jensen, Anders A., Frølund, Bente, Liljefors, T. & Krogsgaard-Larsen, Povl, 2005, In: Journal of Medicinal Chemistry. 48, 15, p. 4705-45 41 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GABA and Glutamate Receptor Ligands and Their Therapeutic Potential in CNS Disorders
Madsen, Ulf, Bräuner, Hans, Greenwood, J. R., Johansen, Tommy Nørskov, Krogsgaard-Larsen, Povl, Liljefors, T., Nielsen, M. & Frølund, Bente, 27 Jan 2005, Drug Discovery Handbook. John Wiley & Sons, Inc., p. 797-907 111 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
GABA and Glutamate Receptor Ligands and Therapeutic Potential in CNS Disorders
Madsen, Ulf, Greenwood, J., Johansen, Tommy Nørskov, Krogsgaard-Larsen, Povl, Liljefors, T., Nielsen, M. & Frølund, Bente, 2005, Drug Discovery Handbook. Wiley, p. 797–907Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Differential effects of two GABA transport inhibitors, tiagabine and EF-1502, on phenytoin-resistant spontaneous bursting in the entorhinal cortex of slices from kainic acid treated rats
Smith-Yockman, M., Saunders, G., Wilcox, K., Clausen, Rasmus Prætorius, Frølund, Bente, Larsson, O., Schousboe, Arne & White, H., 2005, In: Epilepsia. 46, p. 188-188Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Effect of tiagabine and EF1502 on phenytoin-resistant spontaneous bursts in the entorhinal cortex of slices from kainic acid-treated rats
Smith-Yockman, M., Saunders, G., Wilcox, K., Larsson, O., Clausen, Rasmus Prætorius, Frølund, Bente, Schousboe, Arne & White, H., Aug 2005, In: Journal of Neurochemistry. 94, p. 256-256Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Novel cyclic gamma-hydroxybutyrate (GHB) analogs with high affinity and stereoselectivity of binding to GHB sites in rat brain
Wellendorph, Petrine, Høg, S., Greenwood, J. R., de Lichtenberg, A., Nielsen, Birgitte, Frølund, Bente, Brehm, L., Clausen, Rasmus Prætorius & Bräuner, Hans, Oct 2005, In: Journal of Pharmacology and Experimental Therapeutics. 315, 1, p. 346-51Research output: Contribution to journal › Journal article › Research › peer-review
- Published
First Demonstration of a Functional Role for CNS Betaine/GABA Transporter (mGAT2) Based on Synergistic Anticonvulsant Action Among Inhibitors of mGAT1 and mGAT2
White, S., Watson, W. P., Hansen, S. L., Slough, S., Perregård, J., Sarup, A., Bolvig, T., Petersen, G., Larsson, O. M., Clausen, Rasmus Prætorius, Frølund, Bente, Falch, E., Krogsgaard-Larsen, Povl & Schousboe, Arne, 2005, In: The Journal of Pharmacology and Experimental Therapeutics. 312, p. 866–874Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
- Published
Characterization of the GABAA Receptor Recognition Site Through Ligand Design and Pharmacophore Modeling
Frølund, Bente, Jørgensen, A. T., Liljefors, T., Mortensen, M. & Krogsgaard-Larsen, Povl, 2004, Molecular Neuropharmacology: Strategies and Methods. Schousboe, A. & Bräuner-Osborne, H. (eds.). Humana PressResearch output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Carbamoylcholine homologs: synthesis and pharmacology at nicotinic acetylcholine receptors
Jensen, Anders A., Mikkelsen, I. B., Frølund, Bente, Frydenvang, Karla Andrea, Brehm, L., Jaroszewski, J. W., Bräuner, Hans, Falch, E. & Krogsgaard-Larsen, Povl, 2004, In: European Journal of Pharmacology. 497, 2, p. 125-37 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GABA A agonists and partial agonists: THIP (Gaboxadol) as a non-opioid analgesic and a novel type of hypnotic
Krogsgaard-Larsen, Povl, Frølund, Bente, Liljefors, T. & Ebert, B., 15 Oct 2004, In: Biochemical Pharmacology. 68, 8, p. 1573-1580 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Activation of single heteromeric GABAA receptor ion channels by full and partial agonists
Mortensen, M., Kristiansen, Uffe, Ebert, B., Frølund, Bente, Krogsgaard-Larsen, Povl & Smart, T. G., 1 Jun 2004, In: Journal of Physiology. 557, 2, p. 389-413 25 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Activation on single heteromeric GABAA receptor Ion channels by full and partial agonists
Mortensen, M., Kristiansen, Uffe, Ebert, B., Frølund, Bente, Krogsgaard-Larsen, Povl & Smart, T., 2004, In: Journal of Physiology. p. 393–417Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
- Published
Design and synthesis of a new series of 4-alkylated 3-isoxazolol GABAA antagonists
Frølund, Bente, Tagmose, L., Jørgensen, A. T., Kristiansen, Uffe, Stensbøl, T. B., Liljefors, T. & Krogsgaard-Larsen, Povl, 2003, In: European Journal of Medicinal Chemistry. 38, p. 447–449Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design and synthesis of a new series of 4-alkylated 3-isoxazolol GABAA antagonists
Frølund, Bente, Tagmose, L., Jørgensen, A. T., Kristiansen, Uffe, Stensbøl, T. B., Liljefors, T. & Krogsgaard-Larsen, Povl, 1 Apr 2003, In: European Journal of Medicinal Chemistry. 38, 4, p. 447-449 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABAC receptor antagonists
Frølund, Bente, Krehan, D., Krogsgaard-Larsen, Povl, Kehler, J., Johnston, G. A. R. & Chebib, M., 2003, In: Neurochemistry International. 42, p. 561–565Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Carbamoylcholine homologs: novel and potent agonists at neuronal nicotinic acetylcholine receptors
Jensen, Anders A., Frølund, Bente, Bräuner, Hans, Falch, E. & Krogsgaard-Larsen, Povl, 2003, In: Molecular Pharmacology. 64, 4, p. 865-75 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Aza-THIP and Related Analogues of THIP as GABAC Antagonists
Krehan, D., Frølund, Bente, Ebert, B., Nielsen, Birgitte, Krogsgaard-Larsen, Povl, Johnston, G. A. R. & Chebib, M., 2003, In: Bioorganic and Medicinal Chemistry. 11, p. 4891–4896Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Aza-THIP and related analogues of THIP as GABAC antagonists
Krehan, D., Frølund, Bente, Ebert, B., Nielsen, Birgitte, Krogsgaard-Larsen, Povl, Johnston, G. A. R. & Chebib, M., 17 Nov 2003, In: Bioorganic and Medicinal Chemistry. 11, 23, p. 4891-4896 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazol (exo-THPO) and its N-substituted analogs on GABA transport in cultured neurons and astrocytes and by the four cloned mouse GABA transporters
sarup, A., Larsson, O. M., Bolvig, T., Frølund, Bente, Krogsgaard-Larsen, Povl & Schousboe, Arne, 2003, In: Neurochemistry International. 43, p. 445–451Research output: Contribution to journal › Journal article › Research › peer-review
- 2002
- Published
Incorporation of the crossfire Beilstein database into the organic chemistry curriculum at the Royal Danish School of Pharmacy
Christensen, Søren Brøgger, Franzyk, Henrik, Frølund, Bente, Jaroszewski, J. W., Stærk, Dan & Vedsø, P., 1 Jun 2002, In: Journal of Chemical Education. 79, 6, 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Incorporation of the Cross Fire Beilstein database in the organic chemistry curriculum at the Royal Danish School of Pharmacy
Christensen, Søren Brøgger, Franzyk, Henrik, Frølund, Bente, Jaroszewski, J. W., Stærk, Dan & Vedsø, P., 2002, In: Journal of Chemical Education. 79, p. 765-768Research output: Contribution to journal › Journal article › Research
- Published
GABA(A) receptor ligands and their therapeutic potentials.
Frølund, Bente, Ebert, B., Kristiansen, Uffe, Liljefors, T. & Krogsgaard-Larsen, Povl, Aug 2002, In: Current Topics in Medicinal Chemistry. 2, 8, p. 817-832 16 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
GABAA receptor ligands and their therapeutic potentials
Frølund, Bente, Ebert, B., Kristiansen, Uffe, Liljefors, T. & Krogsgaard-Larsen, Povl, 2002, In: Current Topics in Medicinal Chemistry. 2Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel Class of Potent 4-Arylalkyl Substituted 3-Isoxazolol GABAA Antagonists:Synthesis, Pharmacology, and Molecular Modeling
Frølund, Bente, Jørgensen, A. T., Tagmose, L., Stensbøl, T. B., Vestergaard, H. T., Engblom, C., Kristiansen, Uffe, Sanchez, C., Krogsgaard-Larsen, Povl & Liljefors, T., 2002, In: Journal of Medicinal Chemistry. 45, p. 2454–2468Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel class of potent 4-arylalkyl substituted 3-isoxazolol GABAA antagonists: Synthesis, pharmacology, and molecular modeling
Frølund, Bente, Jørgensen, A. T., Tagmose, L., Stensbøl, T. B., Vestergaard, H. T., Engblom, C., Kristiansen, Uffe, Sanchez, C., Krogsgaard-Larsen, Povl & Liljefors, T., 6 Jun 2002, In: Journal of Medicinal Chemistry. 45, 12, p. 2454-2468 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GABAA agonists and partial agonists
Krogsgaard-Larsen, Povl, Frølund, Bente & Liljefors, T., 2002, In: The Chemical Record. 2, p. 419–430Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ligands for the GABAA receptor complex
Krogsgaard-Larsen, Povl, Frølund, Bente, Kristiansen, Uffe & Ebert, B., 2002, Glutamate and GABA receptors of AMPA/kainate receptors and transporters. Taylor & Francis, p. 236–274Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Specific GABAA agonists and partial agonists
Krogsgaard-Larsen, Povl, Frølund, Bente & Liljefors, T., 1 Nov 2002, In: Chemical Record. 2, 6, p. 419-430 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Activity of novel 4-PIOL analogues at human α1β2γ2S GABAAreceptors—correlation with hydrophobicity
Mortensen, M., Frølund, Bente, Jørgensen, A. T., Liljefors, T., Krogsgaard-Larsen, Povl & Ebert, B., 2002, In: European Journal of Medicinal Chemistry. 451, p. 125–132Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Activity of novel 4-PIOL analogues at human α1β2γ2S GABAA receptors - Correlation with hydrophobicity
Mortensen, M., Frølund, Bente, Jorgensen, A. T., Liljefors, T., Krogsgaard-Larsen, Povl & Ebert, B., 13 Sep 2002, In: European Journal of Pharmacology. 451, 2, p. 125-132 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Erratum: Activity of novel 4-PIOL analogues at human α1β2γ2S GABAA receptors - Correlation with hydrophobicity (European Journal of Pharmacology (2000) 451 (125-132))
Mortensen, M., Frølund, Bente, Jorgensen, A. T., Liljefors, T., Krogsgaard-Larsen, Povl & Ebert, B., 25 Oct 2002, In: European Journal of Pharmacology. 453, 2-3, p. 345-346 2 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Correlation between Anticonvulsant Activity and Inhibitory Action on Glial -Aminobutyric Acid Uptake of the Highly Selective Mouse -Aminobutyric Acid Transporter 1 Inhibitor 3-Hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and Its N-Alkylated Analogs
White, S., Sarup, A., Bolvig, T., Petersen, G., Nelson, N., Pickering, Darryl S, Larsson, O. M., Frølund, Bente, Falch, E., Krogsgaard-Larsen, Povl & Schousboe, Arne, 2002, In: Journal of Pharmacology and Experimental Therapeutics. 302, p. 636–644Research output: Contribution to journal › Journal article › Research › peer-review
- 2001
- Published
Ligands for the GABAA receptor complex
Krogsgaard-Larsen, Povl, Frølund, Bente, Kristiansen, Uffe & Ebert, B., 1 Jan 2001, Glutamate and GABA Receptors and Transporters: Structure, Function and Pharmacology. CRC Press, p. 236-274 39 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 2000
- Published
A novel class of potent 3-isoxazolol GABAA antagonists: Design, systhesis, and pharmacology [3]
Frølund, Bente, Tagmose, L., Liljefors, T., Stensbøl, T. B., Engblom, C., Kristiansen, Uffe & Krogsgaard-Larsen, Povl, 28 Dec 2000, In: Journal of Medicinal Chemistry. 43, 26, p. 4930-4933 4 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
A Novel Class of Potent 3-Isoxazolol GABAA Antagonists: Design, Synthesis, and Pharmacology
Frølund, Bente, Tagmose, L., Liljefors, T., Stensbøl, T. B., Engblom, C., Kristiansen, Uffe & Krogsgaard-Larsen, Povl, 2000, In: Journal of Medicinal Chemistry. 43, p. 4930–4933Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects
Krogsgaard-Larsen, Povl, Frølund, Bente & Frydenvang, Karla Andrea, 2000, In: Current Pharmaceutical Design. 6, 12, p. 1193-209 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1999
- Published
Equilibrium binding characteristics of [3H]thiomuscimol
Ebert, B., Frølund, Bente, Diemer, N. & Krogsgaard-Larsen, Povl, 1999, In: Neurochemistry International. 34, p. 427–434Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Selective Inhibitors of Glial GABA Uptake: Synthesis, Absolute Stereochemistry, and Pharmacology of the Enantiomers of 3-Hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole (exo-THPO) and Analogues
Falch, E., Frølund, Bente, Perregaard, Sanchez, C., Søkilde, B., Buur, A., Hansen, A., Frydenvang, Karla Andrea, Brehm, L., Bolvig, T., Larsson, O. M., Schousboe, Arne & Krogsgaard-Larsen, Povl, 1999, In: Journal of Medicinal Chemistry. 42, p. 5402–5414Research output: Contribution to journal › Journal article › Research › peer-review
- 1998
- Published
Inhibitors of γ-aminobutyric acid transport as experimental tools and therapeutic agents
Krogsgaard-Larsen, Povl, Frølund, Bente & Falch, E., 1998, Methods in enzymology. p. 165–175 (Methods in Enzymology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- 1997
- Published
AMPA Receptor Agonists. Synthesis, Protolytic Properties and Pharmacology of 3-Isothiazolol Bioisosteres of Glutamic Acid
Frølund, Bente, Matzen, L., Engesgaard, A., Ebert, B., Didriksen, M., Krogsgaard-Larsen, Povl & Jaroszewski, J., 1997, In: Journal of Medicinal Chemistry. 40, p. 520–527Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GABA-A and GABA-B receptor Agonists, Partial Agonists and Modulators. design and Therapeutic Prospects
Frølund, Bente, Krogsgaard-Larsen, Povl, Kristiansen, Uffe, Frydenvang, Karla Andrea & Ebert, B., 1997, In: European Journal of Pharmaceutical Sciences. 4, p. 355–384Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GABA(A) and GABA(B) receptor agonists, partial agonists, antagonists and modulators: Design and therapeutic prospects
Krogsgaard-Larsen, Povl, Frølund, Bente, Kristiansen, Uffe, Frydenvang, Karla Andrea & Ebert, B., Nov 1997, In: European Journal of Pharmaceutical Sciences. 5, 6, p. 355-384 30 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bioisosterically Modified Dipeptide Excitatory Amino Acid Receptor Antagonists Containing 3-Oxygenated Isothiazole Ring Systems
Matzen, L., Ebert, B., Stensbøl, T. B., Frølund, Bente, Jaroszewski, J. & Krogsgaard-Larsen, Povl, 1997, In: Bioorganic and Medicinal Chemistry. 5, p. 1569–1575Research output: Contribution to journal › Journal article › Research › peer-review
- 1996
- Published
Stereospecific GABA-B receptor antagonism
Frydenvang, Karla Andrea, Frølund, Bente, Kristiansen, Uffe & Krogsgaard-Larsen, Povl, 1996, GABA, receptors, transporters and metabolism. Tanaka, C. & Bowery, N. G. (eds.). Basel: Birkhäuser VerlagResearch output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
GABA-A Receptor Agonists, Partial Agonists and Antagonists
Frølund, Bente, Krogsgaard-Larsen, Povl & Ebert, B., 1996, The GABA Receptors. 2nd ed. Humana PressResearch output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Neuroactive Polyamine Wasp Toxins: Nuclear Magnetic Resonance Spectroscopic Analysis of the Proteolytic Properties of Philantotoxin-343
Jaroszewski, J., Matzen, L., Frølund, Bente & Krogsgaard-Larsen, Povl, 1996, In: Journal of Medicinal Chemistry. 39, p. 515–521Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neuroactive polyamine wasp toxins: Nuclear magnetic resonance spectroscopic analysis of the protolytic properties of philanthotoxin-343
Jaroszewski, J. W., Matzen, L., Frølund, Bente & Krogsgaard-Larsen, Povl, 19 Jan 1996, In: Journal of Medicinal Chemistry. 39, 2, p. 515-521 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1995
- Published
GABA-B Antagonists: Enantiopharmacology of 5-Amino-4-hydroxy-2-methylvaleric Acid and X-Ray Structure of the Eutomer
Frydenvang, Karla Andrea, Kristiansen, Uffe, Frølund, Bente, Herdeis, C. & Krogsgaard-Larsen, Povl, 1995, In: Chirality. 7, p. 526–533Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GABAA Agonists: Resolution and Pharmacology of (+)- and (-)-Isoguvacine Oxide
Frølund, Bente, Jeppesen, L., Krogsgaard-Larsen, Povl & Hansen, J. J., 1995, In: Chirality. 7, p. 434–438Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GABAA agonists: Resolution and pharmacology of (+)‐ and (−)‐isoguvacine oxide
Frølund, Bente, Jeppesen, L., Krogsgaard-Larsen, Povl & Hansen, J. J., 1995, In: Chirality. 7, 6, p. 434-438 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Partial GABAA Receptor Agonists. Synthesis and in Vitro Pharmacology of a Series of Nonannulated Analogs of 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol
Frølund, Bente, Kristiansen, Uffe, Brehm, L., Hansen, A. B., Krogsgaard-Larsen, Povl & Falch, E., 1 Aug 1995, In: Journal of Medicinal Chemistry. 38, 17, p. 3287-3296 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Partial GABAA Receptor agonists. Synthesis and in vitro Pharmacology
Frølund, Bente, Kristiansen, Uffe, Brehm, L., Hansen, A. B., Krogsgaard-Larsen, Povl & Falch, E., 1995, In: Journal of Medicinal Chemistry. 38, p. 3287–3296Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and receptor binding of 5-amino[3H]2methyl-3-isothiazolol ([3H]thiomuscimol), a specific GABAa agonist photoaffinity label
Frølund, Bente, Ebert, B., Lawrence, L. W., Hurt, S. D. & Krogsgaard-Larsen, Povl, 1995, In: Journal of Labelled Compounds and Radiopharmaceuticals. 36, p. 877–889Research output: Contribution to journal › Journal article › Research › peer-review
- 1994
- Published
GABAA receptor agonists, partial agonists, and antagonists. Design and therapeutic prospects
Krogsgaard-Larsen, Povl, Frølund, Bente, Jørgensen, Flemming Steen & Schousboe, Arne, 1994, In: Journal of Medicinal Chemistry. 37, 16, p. 2489-505 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1993
- Published
Design, synthesis and pharmacology of model compounds for indirect elucidation of the topography of AMPA receptor sites
Madsen, Ulf, Frølund, Bente, Lund, Trine Meldgaard, Ebert, B. & Krogsgaard-Larsen, Povl, 1993, In: European Journal of Medicinal Chemistry. 28, p. 791–800Research output: Contribution to journal › Journal article › Research › peer-review
- 1992
- Published
3-hydroxyisoxazole bioiosteres of gaba - synthesis of a series of 4-substituted muscimol analogs and identification of a bicyclic 2-isoxazoline rearrangement product
Hjeds, H., Christensen, I. T., Cornett, Claus, Frølund, Bente, Falch, E., Pedersen, J. B. & Krogsgaardlarsen, P., 1992, In: Acta Chemica Scandinavica. Supplementum. 46, 8, p. 772-777 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1991
- Published
Analogues of the low-efficacy partial GABAA agonist 4-PIOL. Syntheses and in vitro pharmacological studies
De Amici, M., Frølund, Bente, Hjeds, H. & Krogsgaard-Larsen, Povl, Sep 1991, In: European Journal of Medicinal Chemistry. 26, 6, p. 625-631 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Analogues of the Low-efficacy Partial GABA-A Agonist 4-PIOL. Synthesis and in vitro Pharmacological Studies
De Amici, M., Frølund, Bente, Hjeds, H. & Krogsgaard-Larsen, Povl, 1991, In: European Journal of Medicinal Chemistry. 26, p. 625–631Research output: Contribution to journal › Journal article › Research › peer-review
- Published
4-PIOL, a low-efficacy partial GABA-A agonist
Frølund, Bente, Kristiansen, Uffe, Nathan, T., Falch, E., Lambert, J. D. C. & Krogsgaard-Larsen, Povl, 1991, Drug Research related to Neuroactive Amino Acids. MunksgaardResearch output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Novel (Gamma-Aminobutyric Acid)A Agonists and Partial Agonists
Krogsgaard-Larsen, Povl, Frølund, Bente, Kristiansen, Uffe, Lambert, J. D. C., Falch, E. & Curtis, D. R., 1991, Transmitter Amino Acid Receptors. Barnard, E. A. & Costa, E. (eds.). Raven Press, p. 237–249Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
ID: 1302625
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5-(Piperidine-4-yl)-3-hydroxypyrazole: a novel scaffold forprobing the orthosteric GABAA receptor binding site
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Functional characterization of GABAA receptor-mediated modulation of cortical neuron network activity in microelectrode array recordings
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Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABAA receptors
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