Ligands for the GABAA receptor complex
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
The neutral amino acid, 4-aminobutanoic acid (GABA), is an inhibitory transmitter in the central nervous system (CNS). Furthermore, GABA is involved as a neurotransmitter and/or a paracrine effector in the regulation of a variety of physiological mechanisms in the periphery. Some of these latter functions may be under central GABA control, whereas others are managed by local GABA neurons. A large percentage, perhaps the majority, of central neurons are under GABA control. The complex mechanisms underlying the GABA-mediated neurotransmission have been extensively studied using a broad spectrum of electrophysiological, neurochemical, pharmacological, and, in recent years, molecular biological techniques (Curtis and Johnston, 1974; Krnjevic, 1974; Olsen and Venter, 1986; Redburn and Schousboe, 1987; Bowery and Nistico, 1989; Biggio and Costa, 1990; Bowery et al., 1990; Schousboe et al., 1992a; Doble and Martin, 1996; Krogsgaard-Larsen et al., 1997).
Original language | English |
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Title of host publication | Glutamate and GABA Receptors and Transporters : Structure, Function and Pharmacology |
Number of pages | 39 |
Publisher | CRC Press |
Publication date | 1 Jan 2001 |
Pages | 236-274 |
ISBN (Print) | 9780748408818 |
ISBN (Electronic) | 9780203299388 |
Publication status | Published - 1 Jan 2001 |
Bibliographical note
Publisher Copyright:
© 2001 by Taylor & Francis Group, LLC.
ID: 312029340