Dan Stærk

Dan Stærk

Head of Department, Visiting professor

ORCID: 0000-0003-0074-298X

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  1. Published

    HPLC-HRMS-SPE-NMR for accelerated identification of compounds in complex plant extracts: New coumarine derivatives from Coleonema album (Thunb.) Bartl. & Wendl

    de Cássia Lemos Lima, R., Gramsbergen, S. M., Van Staden, J., Jäger, A. K., Kongstad, Kenneth Thermann & Stærk, Dan, Dec 2016, In: Planta Medica. 82, S 01

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  2. Published

    Possible artefacts in the in vitro determination of antimalarial activity of natural products that incorporate into lipid bilayer: apparent antiplasmodial activity of dehydroabietinol, a constituent of Hyptis suaveolens

    Ziegler, H. L., Jensen, T. H., Christensen, J., Stærk, Dan, Hägerstrand, H., Sittie, A. A., Olsen, C. E., Staalsø, Trine, Ekpe, P. & Jaroszewski, J. W., 2002, In: Planta Medica. 68, p. 547-549 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    The antiparasitic compound Licochalcon A is a potent echinocytogenic agent that modifies erythrocyte membrane in the concentration region where the antiplasmodial activity is observed

    Ziegler, H. L., Hansen, Harald S., Stærk, Dan, Christensen, Søren Brøgger, Hägerstrand, H. & Jaroszewski, J. W., 2004, In: Antimicrobial Agents and Chemotherapy. 48, p. 4067-4071

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    New dammarane and malabaricane triterpenes from Caloncoba echinata

    Ziegler, H. L., Stærk, Dan, Christensen, J., Olsen, C. E., Sittie, A. A. & Jaroszewski, J. W., 2002, In: Journal of Natural Products. 65, p. 1764-1768

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Erythrocyte membrane modifying agents and the inhibition of Plasmodium falciparum growth: structure-activity relationships for betulinic acid analogues

    Ziegler, H. L., Franzyk, Henrik, Sairafianpour, M., Tabatabai, M., Tehrani, M. D., Bagherzadeh, K., Hägerstrand, H., Stærk, Dan & Jaroszewski, J. W., 2004, In: Bioorganic & Medicinal Chemistry. 12, p. 119-127

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    In vitro Plasmodium falciparum drug sensitivity assay: inhibition of parasite growth by incorporation of stomatocytogenic amphiphiles into the erythrocyte membrane

    Ziegler, H. L., Stærk, Dan, Christensen, J., Hviid, Lars, Hägerstrand, H. & Jaroszewski, J. W., 2002, In: Antimicrobial Agents and Chemotherapy. 46, 5, p. 1441-6 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Oxetane ring formation in taxol biosynthesis is catalyzed by a bifunctional cytochrome P450 enzyme

    Zhao, Yong, zpm303, zpm303, Xie, Yuman, Duan, Y. T., Andeadelli, A., Pateraki, Irini, Makris, A. M., Pomorski, Thomas Guenther, Stærk, Dan & Kampranis, Sotirios, 2024, In: Journal of the American Chemical Society. 146, p. 801-810

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Quadruple high-resolution α-glucosidase/α-amylase/PTP1B/radical scavenging profiling combined with high-performance liquid chromatography – high-resolution mass spectrometry – solid-phase extraction – nuclear magnetic resonance spectroscopy for identification of antidiabetic constituents in crude root bark of Morus alba L.

    Zhao, Yong, Kongstad, Kenneth Thermann, Jäger, A. K., Nielsen, J. & Stærk, Dan, 2018, In: Journal of Chromatography A. 1556, p. 55-63

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Potential of Polygonum cuspidatum root as an antidiabetic food: Dual high-resolution α-glucosidase and PTP1B inhibition profiling combined with HPLC-HRMS and NMR for identification of antidiabetic constituents

    Zhao, Yong, Chen, M. X., Kongstad, Kenneth Thermann, Jäger, A. K. & Stærk, Dan, 2017, In: Journal of Agricultural and Food Chemistry. 65, p. 4421-4427

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Biosynthesis and biotechnological production of the anti-obesity agent celastrol

    Zhao, Yong, Hansen, N. L., Duan, Yaotao, Prasad, M., Motawie, Mohammed Saddik, Møller, Birger Lindberg, Pateraki, Irini, Stærk, Dan, Bak, Søren, Miettinen, Karel & Kampranis, Sotirios, 2023, In: Nature Chemistry. 15, p. 1236–1246

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    2(5H)-Furanone sesquiterpenes from Eremophila bignoniiflora: High-resolution inhibition profiling and PTP1B inhibitory activity

    Zhao, Yong, Kjaerulff, Louise, Kongstad, Kenneth Thermann, Heskes, A. M., Møller, Birger Lindberg & Stærk, Dan, 2019, In: Phytochemistry. 166, p. 1-8 112054.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Unraveling the complexity of complex mixtures by combining high-resolution pharmacological, analytical and spectroscopic techniques: Antidiabetic constituents in Chinese medicinal plants

    Zhao, Yong, Kongstad, Kenneth Thermann, Liu, Y., He, C. & Stærk, Dan, 2019, In: Faraday Discussions. 218, p. 202-218

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Polypharmacology-labeled molecular networking: An analytical technology workflow for accelerated identification of multiple bioactive constituents in complex extracts

    Zhao, Yong, Gericke, Oliver, Li, T., Kjaerulff, Louise, Kongstad, Kenneth Thermann, Heskes, A. M., Møller, Birger Lindberg, Jørgensen, Flemming Steen, Venter, H., Coriani, S., Semple, S. J. & Stærk, Dan, 2023, In: Analytical Chemistry. 95, 9, p. 4381-4389 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Orthogonal reversed-phase C18 and pentafluorophenyl HPLC separation for phytochemical profiling of serrulatanes in Eremophila denticulata

    Zhao, Yong, Li, T., Kjaerulff, Louise, Venter, H., Coriani, S., Møller, Birger Lindberg, Semple, S. & Stærk, Dan, 2023, In: Journal of Natural Products. 86, 12, p. 2638-2650

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin

    Zaharudin, N. B., Stærk, Dan & Dragsted, Lars Ove, 2019, In: Food Chemistry. 270, p. 481-486 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    High-resolution screening combined with HPLC–HRMS–SPE–NMR for identification of potential health-promoting constituents in sea aster and searocket - New nordic food ingredients

    Wubshet, S. G., Schmidt, J. S., Wiese, S. & Stærk, Dan, 2013, In: Journal of Agricultural and Food Chemistry. 61, 36, p. 8616-8623

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    High resolution antioxidant assay guided HPLC-HRMS-SPE-NMR analysis of Penicillium namyslowskii extract

    Wubshet, S. G., Nyberg, N. & Stærk, Dan, 2012.

    Research output: Contribution to conference › Poster › Research

  18. Published

    High-resolution bioactivity profiling combined with HPLC-HRMS-SPE-NMR: α-glucosidase inhibitors and acetylated ellagic acid rhamnosides from Myrcia palustris DC. (Myrtaceae)

    Wubshet, S. G., Moresco, H. H., Tahtah, Y., Brighente, I. M. C. & Stærk, Dan, 2015, In: Phytochemistry. 116, p. 246-252 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Combined magnetic ligand fishing and high-resolution inhibition profiling for identification of α-glucosidase inhibitory ligands: A new screening approach based on complementary inhibition and affinity profiles.

    Wubshet, S. G., Liu, B., Kongstad, Kenneth Thermann, Böcker, U., Petersen, M. J., Li, T., Wang, J. & Stærk, Dan, 2019, In: Talanta. 200, p. 279-287

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Magnetic ligand fishing as a targeting tool for HPLC-HRMS-SPE-NMR: α-glucosidase inhibitory ligands and alkylresorcinol glycosides from Eugenia catharinae.

    Wubshet, S. G., Brighente, I. M. C., Moaddel, R. & Stærk, Dan, 2015, In: Journal of Natural Products. 78, 11, p. 2657-2665 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Identification of PTP1B and α-glucosidase inhibitory serrulatanes from Eremophila spp. by combined use of dual high-resolution PTP1B and α-glucosidase inhibition profiling and HPLC-HRMS-SPE-NMR

    Wubshet, S. G., Tahtah, Y., Heskes, A. M., Kongstad, Kenneth Thermann, Pateraki, Irini, Hamberger, B. R., Møller, Birger Lindberg & Stærk, Dan, 2016, In: Journal of Natural Products. 79, 4, p. 1063-1072 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Targeting high-performance liquid chromatography-high-resolution mass spectrometry-solid-phase extraction-nuclear magnetic resonance analysis with high-resolution radical scavenging profiles - bioactive secondary metabolites from the endophytic fungus Penicillium namyslowskii

    Wubshet, S. G., Nyberg, N., Tejesvi, M. V., Pirttilä, A. M., Kajula, M., Mattila, S. & Stærk, Dan, 2013, In: Journal of Chromatography A. 1302, p. 34-39

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Identification of Fungal H+-ATPase Inhibitors by Microfractionation and HPLC-HRMS-SPE-NMR

    Wubshet, S. G., Kongstad, Kenneth Thermann, Johannesen, A., Nyberg, N., Jäger, A., Kjellerup, L., Vinther, A. & Stærk, Dan, 2014.

    Research output: Contribution to conference › Poster › Research

  24. Published

    Coupling HPLC-SPE-NMR with a microplate-based high-resolution antioxidant assay for efficient analysis of antioxidants in food – Validation and proof-of-concept study with caper buds

    Wiese, S., Wubshet, S. G., Nielsen, J. & Stærk, Dan, 2013, In: Food Chemistry. 141, 4, p. 4010-4018

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Prolonged Shelf Life in Fermented Milk Products Investigated by Bioassay-Guided Chemometrics

    Vinther, J. M., Garrigues, C., Nyberg, N., Jäger, A., Franzyk, Henrik & Stærk, Dan, 2014.

    Research output: Contribution to conference › Poster › Research

  26. Published

    NMR-based metabolomics and hyphenated NMR techniques – a perfect match in natural products research

    Vinther, J. M., Wubshet, S. G. & Stærk, Dan, Aug 2015, Ethnopharmacology - a Reader. Heinrich, M. & Jäger, A. K. (eds.). Chichester: Wiley, p. 63-74

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  27. Published

    Isolation and structure elucidation of cyclopeptide alkaloids from Ziziphus nummularia and Ziziphus spina-christi by HPLC-DAD-MS and HPLC-PDA-HRMS-SPE-NMR

    Tuenter, E., Foubert, K., Stærk, Dan, Apers, S. & Pieters, L., 2017, In: Phytochemistry. 138, p. 163-169

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    High-resolution inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of PTP1B inhibitors from Vietnamese plants

    Trinh, T. D. B., Jäger, A. K. & Stærk, Dan, 2017, In: Molecules. 22, 7, 12 p., 1228.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Screening selected Vietnamese plants used to treat diabetes for PTP1B inhibitory activity

    Trinh, T. D. B., Stærk, Dan & Jäger, A. K., Dec 2016, In: Planta Medica. 81, S 01, p. 1 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  30. Published

    High-resolution assays combined with HPLC for identification of antidiabetic constituents in Vietnamese plants

    Trinh, T. D. B., Stærk, Dan & Jäger, A. K., 26 Aug 2015.

    Research output: Contribution to conference › Poster › Research

  31. Published

    α-Glucosidase inhibitors from Phyllanthus amarus and Phyllanthus urinaria

    Trinh, T. D. B., Stærk, Dan & Jäger, A. K., Dec 2016, In: Planta Medica. 81, S 01, p. 1 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  32. Published

    Screening for potential α-glucosidase and α-amylase inhibitory constituents from selected Vietnamese plants used to treat type 2 diabetes

    Trinh, T. D. B., Stærk, Dan & Jäger, A. K., 2016, In: Journal of Ethnopharmacology. 186, p. 189-195 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Xanthones from the twigs of Garcinia oblongifolia and their antidiabetic activity

    Trinh, T. D. B., Quach, T. T. T., Bui, D. N., Stærk, Dan, Nguyen, L. D. & Jäger, A. K., 2017, In: Fitoterapia. 118, p. 126-131

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    High-resolution Assays Combined with HPLC-HRMS-SPE-ttNMR for Identification of Antidiabetic Compounds in root of Scutellaria Baicalensis

    Tahtah, Y., Jønsson, L. H., Nyberg, N., Jäger, A. & Stærk, Dan, 2014.

    Research output: Contribution to conference › Poster › Research

  35. Published

    High-resolution PTP1B inhibition profiling combined with high-performance liquid chromatography - high-resolution mass spectrometry - solid-phase extraction - nuclear magnetic resonance spectroscopy: Proof-of-concept and antidiabetic constituents in crude extract of Eremophila lucida

    Tahtah, Y., Wubshet, S. G., Kongstad, Kenneth Thermann, Heskes, A. M., Pateraki, Irini, Møller, Birger Lindberg, Jäger, A. & Stærk, Dan, 2016, In: Fitoterapia. 110, p. 52-58 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Triple aldose reductase/α-glucosidase/radical scavenging high-resolution profiling combined with high-performance liquid chromatography – high-resolution mass spectrometry – solid-phase extraction – nuclear magnetic resonance spectroscopy for identification of antidiabetic constituents in crude extract of Radix Scutellariae

    Tahtah, Y., Kongstad, Kenneth Thermann, Wubshet, S. G., Nyberg, N., Jønsson, L. H., Jäger, A. K., Qinglei, S. & Stærk, Dan, 2015, In: Journal of Chromatography A. 1408, p. 125-132 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Production of novel fusarielins by ectopic activation of the polyketide synthase 9 cluster in Fusarium graminearum

    Sørensen, J. L., Hansen, F. T., Søndergaard, T. E., Stærk, Dan, Lee, T. V., Wimmer, R., Klitgaard, L. G., Purup, S., Giese, H. & Frandsen, R. J. N., 2012, In: Environmental Microbiology. 14, 5, p. 1159-1170 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    NMR-spectroscopic studies, and pharmacological evaluation of alkaloids from some medicinal plants

    Stærk, Dan, 2000, Royal Danish school of Pharmacy.

    Research output: Book/Report › Ph.D. thesis

  39. Published

    A new class of spermidine-derived alkaloids

    Stærk, Dan, Witt, M., Oketch-Rabah, H. A. & Jaroszewski, J. W., 2003, In: Organic Letters. 5, p. 2793-2796

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Spektroskopi – Strukturopklaring vha NMR og IR: Kompendium med forelæsningsslides, tabeller og opgavesamling til en undervisningsdag i spektroskopi ved Institut for Lægemiddeldesign og Farmakologi på Det Sundhedsvidenskabelige Fakultet, Københavns Universitet.

    Stærk, Dan, 2016, 74 p.

    Research output: Book/Report › Compendium/lecture notes

  41. Published

    Vejledning til laboratorieøvelser i 'Organisk Kemi for Biovidenskab'

    Stærk, Dan, 2012, Institut for Grundvidenskab og Miljø, Københavns Universitet. 74 p.

    Research output: Book/Report › Compendium/lecture notes

  42. Published

    Når filmens fiktion bliver virkelighed

    Stærk, Dan, Lambert, M., Sairafianpour, M., Clarkson, C. & Jaroszewski, J. W., 2004, In: Lægemiddelforskning. p. 12-13

    Research output: Contribution to journal › Journal article › Communication

  43. Published

    High-resolution bioactivity profiling combined with HPLC-HRMS-SPE-NMR: accelerated identification of bioactive constituents in food and medicinal plants

    Stærk, Dan, 2015.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  44. Published

    Cytotoxic activity of some phenanthroindolizidine N-Oxide alkaloids from Cynanchum vincetoxicum

    Stærk, Dan, Christensen, J., Lemmich, E., Duus, J. Ø., Olsen, C. E. & Jaroszewski, J. W., 2000, In: Journal of Natural Products. 63, 11, p. 1584-1586

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Bis-intercalation of homodimeric thiazole orange dyes in DNA: effect of modifying the linker

    Stærk, Dan, Hamed, A. A., Pedersen, E. B. & Jacobsen, J. P., 1997, In: Bioconjugate Chemistry. 8, p. 869-877

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Phenanthroindolizidine alkaloids from Vincetoxicum pumilum

    Stærk, Dan, Nezhad, K. B., Asili, J., Emami, S. A., Ahi, A., Sairafianpour, M. & Jaroszewski, J. W., 2005, In: Biochemical Systematics and Ecology. 33, p. 957-960

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    High-resolution bioactivity profiling combined with hyphenated HPLC-SPE-NMR – Investigation of functional food and plants with antifungal constituents

    Stærk, Dan, 2014.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  48. Published

    Structural analysis of complex saponins of Balanites aegyptiaca by 800 MHz 1H NMR spectroscopy

    Stærk, Dan, Chapagain, B. P., lindin, T., Wiesman, Z. & Jaroszewski, J. W., 2006, In: Magnetic Resonance in Chemistry. 44, p. 923-928

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Conformational studies of indole alkaloids corynantheine and dihydrocorynantheine by dynamic 1H NMR spectroscopy and computational methods: steric effects of ethyl vs. vinyl group

    Stærk, Dan, Norrby, P. & Jaroszewski, J. W., 2001, In: Journal of Organic Chemistry. 66, p. 2217-2221

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Fremtidens bæredygtige medicin fra naturen: Nye teknologier hjælper med at finde nålen i høstakken

    Stærk, Dan, 2022, In: Pharma. 2022, 2, p. 20-22

    Research output: Contribution to journal › Contribution to newspaper - Newspaper article › Communication

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ID: 1299056