Ole Jannik Bjerrum
Professor, emeritus
Translational and Clinical Pharmacology
Jagtvej 160
2100 København Ø
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A Paradigm Shift Towards Patient Involvement in Medicines Development and Regulatory Science: Workshop Proceedings and Commentary
Borup, G., Bach, K. F., Schmiegelow, M., Kildemoes, H. W., Bjerrum, Ole Jannik & Westergaard, N., May 2016, In: Therapeutic Innovation & Regulatory Science. 50, 3, p. 304-311 8 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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A novel inhibitor of advanced glycation end- product formation inhibits mesenteric vascular hypertrophy in experimental diabetes
Bjerrum, Ole Jannik, 1999, In: Diabetologica. 42, p. 472-479 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A simple method for the preparation and purification of C1 complement cleaved beta 2-microglobulin from human serum.
Nissen, Mogens Holst, Johansen, B. & Bjerrum, Ole Jannik, 1997, In: Journal of Immunological Methods. 205, 1, p. 29-33 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Alleviation of nociception in rats by treatment with ceftriaxone, a ß-lactam that promote the expression of the excitatory amino acid transporter 2
Bjerrum, Ole Jannik, Abrahamsen, B. & Honoré, P. G. H., Nov 2011.Research output: Contribution to conference › Poster › Communication
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An analysis of the fixed-dose combinations authorized by the European Union, 2009-14: A Focus on benefit-risk and clinial development condition
Sawicki-Wrzask, D., Thomsen, M. & Bjerrum, Ole Jannik, 2015, In: Therapeutic Innovation & Regulatory Science. 49, 4, p. 553-559 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Analysis of the Authorized Target Populations for Fixed Dose Combination Products Between 2000 and 2017 Reveals Discrepancies Between EMA's and FDA's Views on Initial Dual-Therapy
Bjerrum, Ole Jannik, Eichendorff, S. & Alkis, N. B., Mar 2020, In: Therapeutic Innovation & Regulatory Science. 54, 2, p. 297-302 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Analysis of the Authorized Target Populations for Fixed Dose Combination Products Between 2000 and 2017 Reveals Discrepancies Between EMA’s and FDA’s Views on Initial Dual-Therapy
Bjerrum, Ole Jannik, Eichendorff, S. & Alkis, N. B., 2019, In: Therapeutic Innovation & Regulatory Science. 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Beta-lactam antibiotic as dose dependent analgesic treatment of neuropathic pain
Bjerrum, Ole Jannik, Abrahamsen, B. & Honoré, P. G. H., 2011.Research output: Contribution to conference › Poster › Research › peer-review
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Bivirkningsmonitorering af lægemidler: en ny udfordring af apoteksfarmaceuter
Christensen, S. T. & Bjerrum, Ole Jannik, 2009, In: Lægemiddelforskning. p. 49-51Research output: Contribution to journal › Journal article › Communication
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Blå medicin mod smerter
Boulakou, A., Bjerrum, Ole Jannik & Honoré, P. G. H., 2012, In: Lægemiddelforskning. 2012, p. 18-19 2 p.Research output: Contribution to journal › Journal article › Communication
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Body of evidence and approaches applied in the clinical development programme of fixed-dose combinations in the European Union from 2010 to 2016
Nøhr-Nielsen, A., De Bruin, M. L., Thomsen, M., Pipper, C. B., Lange, Theis, Bjerrum, Ole Jannik & Lund, Trine Meldgaard, 2019, In: British Journal of Clinical Pharmacology. 85, 8, p. 1829-1840 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ceftriaxone, an EAAT-2 transporter inducer, shows antinociceptive effects in acute and neuropathic pain models
Bjerrum, Ole Jannik, Abrahamsen, B. & Honoré, P. G. H., 2011.Research output: Contribution to conference › Poster › Research › peer-review
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Centrally mediated anti-noceptive action of GABAA receptor agonists in the spared nerve injury model of neuropathic pain
Bjerrum, Ole Jannik, 2005, In: European Journal of Pharmaceutical Sciences. 516, p. 131-138 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of drug combination effects in a rat model of neuropathic pain ny population modelling and simulation of response-time profiles
Bjerrum, Ole Jannik & Honoré, P. G. H., 2011.Research output: Contribution to conference › Poster › Research › peer-review
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Co-administered gabapentin and venlafaxine in nerve injured rats: effect on mechanical hypersensitivity, motor function and pharmacokinetics
Folkesson, A. J. M., Honoré, P. G. H. & Bjerrum, Ole Jannik, 2009, In: Scandinavian Journal of Pain. 1, 2, p. 91-97Research output: Contribution to journal › Journal article › Research › peer-review
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Combination therapy for neuropathic pain: Donepezil improves gabapentins antinoceptive effect in SNI rats
Bjerrum, Ole Jannik & Honoré, P. G. H., 2011.Research output: Contribution to conference › Poster › Research › peer-review
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Community pharmacies as platform for collection of real-world evidence of medicines usage explored through a pilot study: From standard T2D medication to treatment with the injectable combination product Xultophy
Alkis, N., Nørgaard, Lotte Stig & Bjerrum, Ole Jannik, 2019.Research output: Contribution to conference › Poster › Research › peer-review
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Community pharmacy driven pharmacovigilance
Bjerrum, Ole Jannik & Christensen, S. T., 2010.Research output: Contribution to conference › Poster › Communication
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Comparative pharmacokinetics between a microdose and therapeutic dose for clarithromycin, sumatriptan, propafenone, paracetamol (acetaminophen) and phenobarbital in human volunteers
Lappin, G., Shishikura, Y., Jochemsen, R., Weaver, R. J., Gesson, C., Houston, J. B., Oosterhuis, B., Bjerrum, Ole Jannik, Grynkiewicz, G., Alder, J., Rowland, M. & Garner, C., 20 Apr 2011, In: European Journal of Pharmaceutical Sciences. 43, 3, p. 141-150 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Decrease in nocifensive behaviour in rats after treatment with the EAAT-2 transporter inducer cetriaxone
Bjerrum, Ole Jannik, Honoré, P. G. H. & Abrahamsen, B., 2011.Research output: Contribution to conference › Poster › Research › peer-review
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Demonstrating Contribution of Components of Fixed-Dose Drug Combinations Through Longitudinal Exposure-Response Analysis
Nøhr-Nielsen, A., Lange, Theis, Forman, Julie Lyng, Papathanasiou, T., Foster, D. J. R., Upton, R. N., Bjerrum, Ole Jannik & Lund, Trine Meldgaard, 2020, In: The AAPS Journal. 22, 2, 32.Research output: Contribution to journal › Journal article › Research › peer-review
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Development of quantitative Pharmacology Pharmacometrics in Denmark
Bjerrum, Ole Jannik & Honoré, P. G. H., 2011.Research output: Contribution to conference › Poster › Research › peer-review
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Development of quantitative pharmacology-pharmacometrics in Denmark
Honoré, P. G. H., Bjerrum, Ole Jannik, Lund, Trine Meldgaard, Angelo, H., Ingwersen, S. H., Thygesen, P., Kristensen, K. & Larsen, F., 2011.Research output: Contribution to conference › Poster › Research
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Differential effects of repeated low dose treatment with the cannabinoid agonist WIN 55,212-2 in experimental models of bone cancer pain and neuropathic pain
Hald, A., Ding, M., Egerod, Kristoffer Lihme, Hansen, R. R., Konradsen, D., Jørgensen, S. G., Atalay, B., Nasser, A., Bjerrum, Ole Jannik & Heegaard, Anne-Marie, 2008, In: Pharmacology, Biochemistry and Behavior. 91, 1, p. 38-46 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Donepezil anvendt ved neuropatisk smerte
Bjerrum, Ole Jannik & Bjerrum, H. J., 2013, In: Ugesskrift for læger. 175, 42, p. 2493-2494 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Donepezil as add-on to gabapentin for post-traumatic neuropathic pain: an exploratory study
Basnet, A., Butler, S., Honoré, P. G. H., Butler, M., Gordh, T. E., Kristensen, K. K. & Bjerrum, Ole Jannik, 2013, In: Acta Anaesthesiologica Scandinavica. 58, 1, p. 61-73 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dorsal horn volume loss and pain pathway changes in Cavalier King Charles Spaniels with syringomyelia, signs of pain, and phantom scratching
Mortensen, D., Thoefner, M. S., Agerholm, Jørgen Steen, Slumstrup, L., Jensen, T. S., Bjerrum, Ole Jannik, Berendt, Mette & Nyengaard, J. R., 2022, In: Pain. 163, 12, p. 2365-2379Research output: Contribution to journal › Journal article › Research › peer-review
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Dose and administration-period play a key role in the effect of ceftriaxone on neuropathic pain in CCi-operated rats
Bjerrum, Ole Jannik, Honoré, P. G. H., Frederiksen, K. K., Kristensen, P., Abrahamsen, B. & Gegelashvili, G., 2013.Research output: Contribution to conference › Poster › Research › peer-review
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Dose-dependent effect of ceftriaxone (A beta-lactam) on mechanical pain hypersensitivity in the CCI nerve rat model
Bjerrum, Ole Jannik, Frederiksen, K. K., Kristensen, P., Abrahamsen, B. & Honoré, P. G. H., 2013.Research output: Contribution to conference › Poster › Research › peer-review
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Drug-drug combinations revisited
Bjerrum, Ole Jannik, Gautam, Y., Honoré, P. G. H. & Vana, V., 15 Jan 2014, In: European Journal of Hospital Pharmacy - Science and Practice. 21, 1, p. 8-12 5 p.Research output: Contribution to journal › Review › Research › peer-review
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Effect of GTP-cyclohydrolase deficiency in the HPH-1mouse on acute and inflammatory pain
Nasser, A., Bjerrum, Ole Jannik & Heegaard, Anne-Marie, 2010.Research output: Contribution to conference › Conference abstract for conference › Communication
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Effective integration of systems biology, biomarkers, biosimulation and modelling in streamlining drug development
Krishna, R., Schaefer, H. G. & Bjerrum, Ole Jannik, 2007, In: European Journal of Pharmaceutical Sciences. 31, 1, p. 62-67Research output: Contribution to journal › Letter › Research
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Effects of the excitatory amino acid transporter subtype 2(EAAT-2) inducer ceftriaxone on different pain modalities in rat
Eljaja, L., Bjerrum, Ole Jannik, Honoré, P. G. H. & Abrahamsen, B., 2011, In: Scandinavian Journal of Pain. 2, 3, p. 132-136 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Electrophoretic and chromatographic differentiation of two forms of albumin in equilibrium at neutral pH. New screening technique of ligand binding to albumin
Bjerrum, Ole Jannik, 1995, In: Electrophoresis. 16, 8, p. 1401-1407 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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European new safe and innovative medicines initiatives: history and progress (through December 2009)
Bjerrum, Ole Jannik & H. Linden, H., Mar 2011, Translational medicine and drug discovery. Cambridge: Cambridge University Press, p. 265-288 23 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication
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Excellence in education and training advances competitiveness of the pharmaceutical industry in Europe
Bjerrum, Ole Jannik, 2011, In: European Journal of Pharmaceutical Sciences. 44, 2, p. 174-175 2 p.Research output: Contribution to journal › Comment/debate › Research
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Fast detection of adverse drug reactions of new drugs by community pharmacists
Christensen, S. T. & Bjerrum, Ole Jannik, 2010, In: Drug Safety. 33, 10, p. 928Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Fixed Dose Combinations. The Physician attitude to the wider use. A pilot study
Bjerrum, Ole Jannik & Vana, V., 2013.Research output: Contribution to conference › Poster › Research › peer-review
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Fixed drug combinations: are current regulatory guidelines in the EU and US adequate for effectively guiding Development?
Bjerrum, Ole Jannik, Gautam, Y. & Schmiegelow, M., 2013.Research output: Contribution to conference › Poster › Research › peer-review
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From Face-to-fase training to blended learning in the postgraduate program SafeSciMet - a case study
Bjerrum, Ole Jannik, Vos, C., Dragovic, S., Jochimsen, M., Dirac, J., Foth, H. & Wiese, J., 2017, In: European Journal of Pharmaceutical Sciences. 96, p. III-VIII 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetik kan forudsige følsomhed for smerte
Nasser, A., Bjerrum, Ole Jannik, Heegaard, Anne-Marie & Møller, L. B., 2010, In: Lægemiddelforskning. 2010, p. 34-36Research output: Contribution to journal › Journal article › Research
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Glutamate Transport System as a Novel Therapeutic Target in Chronic Pain: Molecular Mechanisms and Pharmacology
Gegelashvili, G. & Bjerrum, Ole Jannik, 2017, Glial Amino Acid Transporters. Springer, Vol. 16. p. 225-253 29 p. (Advances in Neurobiology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Glutamate transport system as a key constituent of glutamosome: Molecular pathology and pharmacological modulation in chronic pain
Gegelashvili, G. & Bjerrum, Ole Jannik, 2019, In: Neuropharmacology. 161, 107623.Research output: Contribution to journal › Review › Research › peer-review
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Growth hormone releasing hexapeptide (GHRP-6)-activates the inositol (1,4,5)-Triphosphate/diacylglycerol pathway
Bjerrum, Ole Jannik, 1995, In: Journal of Receptors and Signal Transduction. 15, 1-4, p. 311-323 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Heterozygous mutations in GTP-cyclohydrolase-1 reduce BH4 biosynthesis but not pain sensitivity
Nasser, A., Møller, A. T., Hellmund, V., Thorborg, S. S., Jespersgaard, C., Bjerrum, Ole Jannik, Dupontd, E., Nachman, G., Lykkesfeldt, Jens, Jensen, T. S. & Møller, L. B., 2018, In: Pain. 159, 6, p. 1012-1024 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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High-affinity Glutamate Transporters in Pain: An Emerging and Therapeutic Target
Gegelashvili, G. & Bjerrum, Ole Jannik, 2015, In: Journal of Neurochemistry. 6, p. 712-30 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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How first time-in human studies are being performed; A survey of phase 1 dose escalation trials in healthy volunteers published between 1995-2004
Bjerrum, Ole Jannik, 2005, In: Journal of Clinical Pharmacology. 45, p. 1123-1136 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Identifying Off-label Prescriptions trough Data Mining in Danish Community Pharmacy Servers: An exploratory Study on Desmopressin, Diclofenac, Fucidin, Mirtazapine and Quetiapine
Bjerrum, Ole Jannik & Androlyte, M., Aug 2018, In: Basic & Clinical Pharmacology & Toxicology. 123 , 2, p. 155–160 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Immunochemically identical hydrophilic and amphiphilic forms of the bovine adrenomedullary dopamine beta-hydroxylase
Bjerrum, Ole Jannik, Helle, K. B. & Bock, E. M., 1979, In: Biochemical Journal. 181, 1, p. 231-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Impaired behavioural pain responses in hph-1 mice with inherited deficiency in GTP cyclohydrolase 1 in models of inflammatory pain
Nasser, A., Bjerrum, Ole Jannik, Heegaard, Anne-Marie, Møller, A. T., Larsen, M., Dalbøge, L. S., Dupont, E., Jensen, T. S. & Møller, L. B., 19 Feb 2013, In: Molecular Pain. 9, p. 5Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1302721
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Genetik kan forudsige følsomhed for smerte
Research output: Contribution to journal › Journal article › Research
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217
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Pregabalin alleviates clinical signs of syringomyelia-related central neuropathic pain in Cavalier King Charles Spaniel dogs: a randomized controlled trial
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Mechanical sensory threshold in Cavalier King Charles spaniels with syringomyelia-associated scratching and control dogs
Research output: Contribution to journal › Journal article › Research › peer-review
Published