Osman Asghar Mirza
Associate Professor
Biopharmaceuticals
Jagtvej 162, 2100 København Ø
- Published
Activation of ERK, JNK, Akt, and G-protein coupled signaling by hybrid angiotensin II AT1/bradykinin B2 receptors expressed in HEK-293 cells
Yu, J., Lubinsky, D., Tsomaia, N., Huang, Z., Taylor, L., Mierke, D., Navarro, J., Mirza, Osman Asghar & Polgar, P., 2007, In: Journal of Cellular Biochemistry. 101, 1, p. 192-204Research output: Contribution to journal › Journal article › Research › peer-review
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An Optimized Screen Reduces the Number of GA Transporters and provides Insights into NPF Substrate Determinants
Wulff, N., Ernst, H. A., Jørgensen, M. E., Lambertz, S., Maierhofer, T., Belew, Zeinu Mussa, Crocoll, C., Motawia, M. S., Geiger, D., Jørgensen, Flemming Steen, Mirza, Osman Asghar & Nour-Eldin, Hussam Hassan, 2019, bioRxiv.Research output: Working paper › Preprint › Research
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An Optimized Screen Reduces the Number of GA Transporters and Provides Insights Into Nitrate Transporter 1/Peptide Transporter Family Substrate Determinants
Wulff, N., Ernst, H. A., Jørgensen, M. E., Lambertz, S., Maierhofer, T., Belew, Zeinu Mussa, Crocoll, C., Motawie, Mohammed Saddik, Geiger, D., Jørgensen, Flemming Steen, Mirza, Osman Asghar & Nour-Eldin, Hussam Hassan, 3 Oct 2019, In: Frontiers in Plant Science. 10, 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure and molecular mechanism of a nucleobase-cation-symport-1 family transporter
Weyand, S., Shimamura, T., Yajima, S., Suzuki, S., Mirza, Osman Asghar, Krusong, K., Carpenter, E. P., Rutherford, N. G., Hadden, J. M., O'Reilly, J., Ma, P., Saidijam, M., Patching, S. G., Hope, R. J., Norbertczak, H. T., Roach, P. C. J., Iwata, S., Henderson, P. J. F. & Cameron, A. D., 2008, In: Science. 322, 5902, p. 709-713Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Over-expression, purification and characterization of an Asc-1 homologue from Gloeobacter violaceus
Wang, X., Hald, H., Ernst, H. A., Egebjerg, J., Christensen, K. V., Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Mirza, Osman Asghar, 2010, In: Protein Expression and Purification. 71, 2, p. 179-183Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Activity of the Human Rhinovirus 3C Protease Studied in Various Buffers, Additives and Detergents Solutions for Recombinant Protein Production
Ullah, R., Shah, M. A., Tufail, S., Ismat, F., Imran, M., Iqbal, M., Mirza, Osman Asghar & Rhaman, M., 2016, In: PloS one. 11, 4, 13 p., e0153436.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of potent epitopes on hexon capsid protein and their evaluation as vaccine candidates against infections caused by members of Adenoviridae family
Tufail, S., Shah, M. A., Zafar, M., Asif, T. A., Shehzad, A., Shah, M. S., Habib, M., Saleemi, M. K., Muddassar, M., Mirza, Osman Asghar, Iqbal, M. & Rahman, M., 2021, In: Vaccine. 39, 27, p. 3560-3564 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Highly soluble and stable ‘insertion domain’ of the capsid penton base protein provides complete protection against infections caused by fowl adenoviruses
Tufail, S., Shah, M. A., Asif, T. A., Ullah, R., Shehzad, A., Ismat, F., Shah, M. S., Habib, M., Calisto, B. M., Mirza, Osman Asghar, Iqbal, M. & Rahman, M., 2022, In: Microbial Pathogenesis. 173, Part A, 6 p., 105835.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Restraining the multidrug efflux transporter STY4874 of Salmonella Typhi by reserpine and plant extracts
Tariq, A., Sana, M., Shaheen, A., Ismat, F., Mahboob, S., Rauf, W., Mirza, Osman Asghar, Iqbal, M. & Rahman, M., 2019, In: Letters in Applied Microbiology. 69, 3, p. 161-167Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structures of OppA and PstS from Yersinia pestis indicate variability of interactions with transmembrane domains
Tanabe, M., Mirza, Osman Asghar, Bertrand, T., Atkins, H. S., Titball, R. W., Iwata, S., Brown, K. A. & Byrne, B., 2007, In: Acta Crystallographica. Section D: Biological Crystallography. 63, 11, p. 1185-1193Research output: Contribution to journal › Journal article › Research › peer-review
The ABC transporter protein OppA provides protection against experimental Yersinia pestis infection
Tanabe, M., Atkins, H. S., Harland, D. N., Elvin, S. J., Stagg, A. J., Mirza, Osman Asghar, Titball, R. W., Byrne, B. & Brown, K. A., Jun 2006, In: Infection and Immunity. 74, 6, p. 3687-91 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Crystal structure of sucrose phosphorylase from Bifidobacterium adolescentis
Sprogøe, D., van den Broek, L. A. M., Mirza, Osman Asghar, Kastrup, Jette Sandholm Jensen, Voragen, A. G. J., Gajhede, Michael & Skov, L., 10 Feb 2004, In: Biochemistry. 43, 5, p. 1156-62 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dominating IgE-binding epitope of Bet v 1, the major allergen of birch pollen, characterized by X-ray crystallography and site-directed mutagenesis
Spangfort, M. D., Mirza, Osman Asghar, Ipsen, H., Van Neerven, R. J. J., Gajhede, Michael & Larsen, J., 2003, In: Journal of Immunology. 171, 6, p. 3084-90 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Crystallization and preliminary X-ray analysis of birch-pollen allergen Bet v 1 in complex with a murine monoclonal IgG Fab' fragment
Spangfort, M. D., Mirza, Osman Asghar & Gajhede, Michael, Dec 1999, In: Acta Crystallographica. Section D: Biological Crystallography. 55, Pt 12, p. 2035-6 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Anandamide and 2-AG Are Endogenously Present within the Laterodorsal Tegmental Nucleus: Functional Implications for a role of eCBs in arousal
Soni, N., Prabhala, B. K., Mehta, V., Mirza, Osman Asghar & Kohlmeier, Kristi Anne, Jun 2017, In: Brain Research. 1665, p. 74-79 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Crystal structure of the Glu328Gln mutant of Neisseria polysaccharea amylosucrase in complex with sucrose and maltoheptaose
Skov, L. K., Mirza, Osman Asghar, Sprogøe, D., van der Veen, B., Remaud-Simeon, M., Albenne, C., Monsan, P. & Gajhede, Michael, 1 Jan 2006, In: Biocatalysis and Biotransformation. 24, 1-2, p. 99-105 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Oligosaccharide and sucrose complexes of amylosucrase. Structural implications for the polymerase activity
Skov, L. K., Mirza, Osman Asghar, Sprogøe, D., Dar, I., Remaud-Simeon, M., Albenne, C., Monsan, P. & Gajhede, Michael, 6 Dec 2002, In: Journal of Biological Chemistry. 277, 49, p. 47741-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The structure of amylosucrase from Deinococcus radiodurans has an unusual open active-site topology
Skov, L. K., Pizzut-Serin, S., Remaud-Simeon, M., Ernst, H. A., Gajhede, Michael & Mirza, Osman Asghar, Sep 2013, In: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online. 69, Pt 9, p. 973-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystallization and preliminary X-ray studies of recombinant amylosucrase from Neisseria polysaccharea
Skov, L. K., Mirza, Osman Asghar, Henriksen, A., Potocki de Montalk, G., Remaud-Simeon, M., Sarcabal, P., Willemot, R. M., Monsan, P. & Gajhede, M., Feb 2000, In: Acta Crystallographica. Section D: Biological Crystallography. 56, Pt 2, p. 203-5 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Amylosucrase, a glucan-synthesizing enzyme from the alpha-amylase family
Skov, L. K., Mirza, Osman Asghar, Henriksen, A., De Montalk, G. P., Remaud-Simeon, M., Sarçabal, P., Willemot, R. M., Monsan, P. & Gajhede, Michael, 6 Jul 2001, In: Journal of Biological Chemistry. 276, 27, p. 25273-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Peptide Selectivity of the Proton-Coupled Oligopeptide Transporter from Neisseria meningitidis
Sharma, N., Aduri, N. G., Iqbal, A., Prabhala, B. K. & Mirza, Osman Asghar, 2016, In: Journal of Molecular Microbiology and Biotechnology. 26, 5, p. 312-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutational Diversity in the Quinolone Resistance-Determining Regions of Type-II Topoisomerases of Salmonella Serovars
Shaheen, A., Tariq, A., Iqbal, M., Mirza, Osman Asghar, Haque, A., Walz, T. & Rahman, M., 2021, In: Antibiotics. 10, 12, 26 p., 1455.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural Biology Meets Drug Resistance: An Overview on Multidrug Resistance Transporters
Shaheen, A., Iqbal, M., Mirza, Osman Asghar & Rahman, M., 1 Jun 2017, In: Journal of the Indian Institute of Science. 97, 2, p. 165-175 11 p.Research output: Contribution to journal › Review › Research › peer-review
- Accepted/In press
Identification of additional mechanistically important residues in the multidrug transporter styMdtM of Salmonella Typhi
Shaheen, A., Tariq, A., Ismat, F., Naveed, H., De Zorzi, R., Iqbal, M., Storici, P., Mirza, Osman Asghar, Walz, T. & Rahman, M., 2023, (Accepted/In press) In: Journal of Biomolecular Structure and Dynamics.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of the multidrug efflux transporter styMdtMfrom Salmonella enterica serovar Typhi
Shaheen, A., Ismat, F., Iqbal, M., Haque, A., Ul-Haq, Z., Mirza, Osman Asghar, De Zorzi, R., Walz, T. & Rahman, M., 2021, In: Proteins: Structure, Function, and Bioinformatics. 89, 9, p. 1193-1204Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transcriptional regulation of drug resistance mechanisms in Salmonella: where we stand and what we need to know
Shaheen, A., Tariq, A., Shehzad, A., Iqbal, M., Mirza, Osman Asghar, Maslov, D. A. & Rahman, M., 2020, In: World journal of microbiology & biotechnology. 36, 6, 8 p., 85.Research output: Contribution to journal › Review › Research › peer-review
- Published
Characterization of putative multidrug resistance transporters of the major facilitator-superfamily expressed in Salmonella Typhi
Shaheen, A., Ismat, F., Iqbal, M., Haque, A., De Zorzi, R., Mirza, Osman Asghar, Walz, T. & Rahman, M., 2015, In: Journal of Infection and Chemotherapy. 21, 5, p. 357–362 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reserpine Is the New Addition into the Repertoire of AcrB Efflux Pump Inhibitors
Shaheen, A., Afridi, W. A., Mahboob, S., Sana, M., Zeeshan, N., Ismat, F., Mirza, Osman Asghar, Iqbal, M. & Rahman, M., 10 Aug 2019, In: Molecular Biology. 53, 4, p. 674-684 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Physiological response in E. coli to YdgR overexpression depends on whether the protein has an intact function
Sajid, Salvia, Salas, L. H., Rafiq, M., Lund, T., Jørgensen, M. G., Honoré, B., Christensen, L. P., Hansen, Paul Robert, Franzyk, Henrik, Mirza, Osman Asghar & Prabhala, B. K., 2023, In: Biochemical and Biophysical Research Communications. 661, p. 42-49Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Substrate space analysis of the bacterial proton-coupled oligopeptide transporter YdgR by cheminformatics
Sajid, Salvia, Nielsen, M. M. K., Khalil, R., Hansen, Paul Robert, Franzyk, Henrik, Jørgensen, M. G., Christensen, L. P., Mirza, Osman Asghar & Prabhala, B. K., 2023, In: FEMS Microbiology Letters. 370, 9 p., fnad052.Research output: Contribution to journal › Journal article › Research › peer-review
- Accepted/In press
The Y-ome Conundrum: Insights into Uncharacterized Genes and Approaches for Functional Annotation
Sajid, Salvia, Mashkoor, M., Jørgensen, M. G., Christensen, L. P., Hansen, Paul Robert, Franzyk, Henrik, Mirza, Osman Asghar & Prabhala, B. K., 2023, (Accepted/In press) In: Molecular and Cellular Biochemistry. 12 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Expression of ESAT-6 antigen from Mycobacterium tuberculosis in broccoli: An edible plant
Saba, K., Sameeullah, M., Asghar, A., Gottschamel, J., Latif, S., Lössl, A. G., Mirza, B., Mirza, Osman Asghar & Waheed, M. T., 2020, In: Biotechnology and Applied Biochemistry. 67, 1, p. 148-157 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Expression, purification and characterization of human proton-coupled oligopeptide transporter 1 hPEPT1
Rafiq, M., Ernst, H. A., Aduri, N. G., Prabhala, B. K., Tufail, S., Rahman, M., Bloch, Magnus Borup, Mirza, N., Taylor, Nicholas M I, Boesen, T., Gajhede, Michael & Mirza, Osman Asghar, 2022, In: Protein Expression and Purification. 190, 7 p., 105990.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of synthetic peptides by mass spectrometry
Prabhala, B. K., Mirza, Osman Asghar, Højrup, P. & Hansen, Paul Robert, 2015, Methods in Molecular Biology: Peptide Antibiodies. Springer, p. 77-82Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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New insights into the substrate specificities of proton-coupled oligopeptide transporters from E. coli by a pH sensitive assay
Prabhala, B. K., Aduri, N. G., Jensen, J. M., Ernst, H. A., Iram, N., Rahman, M. & Mirza, Osman Asghar, 16 Jan 2014, In: FEBS Letters. 588, 4, p. 560-565Research output: Contribution to journal › Journal article › Research › peer-review
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Investigation of the substrate specificity of the proton coupled peptide transporter PepTSo from Shewanella oneidensis
Prabhala, B. K., Aduri, N. G., Hald, H. & Mirza, Osman Asghar, 2015, In: International Journal of Peptide Research and Therapeutics. 15, 21, p. 1-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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PTR2/POT/NPF transporters: what makes them tick?
Prabhala, B. K., Rahman, M., Nour-Eldin, Hussam Hassan, Jørgensen, Flemming Steen & Mirza, Osman Asghar, 2021, In: Advances in Protein Chemistry and Structural Biology. 123, p. 219-240 22 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR
Prabhala, B. K., Aduri, N. G., Iqbal, M., Rahman, M., Gajhede, Michael, Hansen, Paul Robert & Mirza, Osman Asghar, 16 Feb 2017, In: Research in Microbiology. 168, 5, p. 443-449Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The prototypical proton-coupled oligopeptide transporter YdgR from Escherichia coli facilitates chloramphenicol uptake into bacterial cells
Prabhala, B. K., Aduri, N. G., Sharma, N., Shaheen, A., Sharma, A., Iqbal, M., Hansen, Paul Robert, Brasen, C., Gajhede, Michael, Rahman, M. & Mirza, Osman Asghar, 2018, In: The Journal of Biological Chemistry. 293, p. 1007-1017Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer
Pippione, A. C., Kovachka, S., Vigato, C., Bertarini, L., Mannella, I., Sainas, S., Rolando, B., Denasio, E., Piercy-Mycock, H., Romalho, L., Salladini, E., Adinolfi, S., Zonari, D., Peraldo-Neia, C., Chiorino, G., Passoni, A., Mirza, O. A., Frydenvang, K., Pors, K., Lolli, M. L. & 3 others, , 2024, In: European Journal of Medicinal Chemistry. 268, 20 p., 116193.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural Insights into the Substrate Transport Mechanisms in GTR Transporters through Ensemble Docking
Peña‐Varas, C., Kanstrup, Christa, Vergara‐jaque, A., González‐avendaño, M., Crocoll, C., Mirza, Osman Asghar, Dreyer, I., Nour-Eldin, Hussam Hassan & Ramírez, D., 2022, In: International Journal of Molecular Sciences. 23, 3, 20 p., 1595.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Changing substrate specificity and iteration of amino acid chain elongation in glucosinolate biosynthesis through targeted mutagenesis of Arabidopsis methylthioalkylmalate synthase1
Petersen, A., Gram Hansen, L., Mirza, N., Crocoll, C., Mirza, Osman Asghar & Halkier, Barbara Ann, Jul 2019, In: Bioscience Reports. 39, p. 1-15 BSR20190446.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The structure of the complex between a branched pentasaccharide and Thermobacillus xylanilyticus GH-51 arabinofuranosidase reveals xylan-binding determinants and induced fit
Paës, G., Skov, L. K., O'Donohue, M. J., Rémond, C., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Mirza, Osman Asghar, 2008, In: Biochemistry. 47, 28, p. 7441-7451Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Arabidopsis ATP A2 peroxidase. Expression and high-resolution structure of a plant peroxidase with implications for lignification.
Ostergaard, L., Teilum, Kaare, Mirza, Osman Asghar, Mattsson, O., Petersen, M., Welinder, K. G., Mundy, J., Gajhede, Michael & Henriksen, A., 2000, In: Plant Molecular Biology. 44, 2, p. 231-43 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sulpiride Serves, a Substrate for the Gut Microbiome
Mukhtar, I., Anwar, H., Mirza, Osman Asghar, Ali, Q., Ijaz, M. U., Hume, M., Prabhala, B. K., Iftikhar, A., Hussain, G., Sohail, M. U. & Khan, K. U. R., 2021, In: Dose-Response. 19, 1, 7 p., 1559325820987943.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Detection of Paracetamol as substrate of the gut microbiome
Mukhtar, I., Anwar, H., Hussain, G., Rasul, A., Naqvi, S. A. R., Faisal, M. N., Mustafa, I., Malik, S., Shaukat, A., Mirza, Osman Asghar & Sohail, M. U., Mar 2019, In: Pakistan Journal of Pharmaceutical Sciences. 32, 2 (Supplementary), p. 751-757 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural evidence for induced fit and a mechanism for sugar/H+ symport in LacY
Mirza, Osman Asghar, Guan, L., Verner, G., Iwata, S. & Kaback, H. R., 22 Mar 2006, In: E M B O Journal. 25, 6, p. 1177-83 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dominant epitopes and allergic cross-reactivity: complex formation between a Fab fragment of a monoclonal murine IgG antibody and the major allergen from birch pollen Bet v 1
Mirza, Osman Asghar, Henriksen, A., Ipsen, H., Larsen, J. N., Wissenbach, M., Spangfort, M. D. & Gajhede, Michael, 1 Jul 2000, In: Journal of Immunology. 165, 1, p. 331-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Arabidopsis thaliana peroxidase N: structure of a novel neutral peroxidase
Mirza, Osman Asghar, Henriksen, A., Ostergaard, L., Welinder, K. G. & Gajhede, Michael, Mar 2000, In: Acta Crystallographica. Section D: Biological Crystallography. 56, Pt 3, p. 372-5 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Crystal structures of amylosucrase from Neisseria polysaccharea in complex with D-glucose and the active site mutant Glu328Gln in complex with the natural substrate sucrose
Mirza, Osman Asghar, Skov, L. K., Remaud-Simeon, M., Potocki de Montalk, G., Albenne, C., Monsan, P. & Gajhede, M., 31 Jul 2001, In: Biochemistry. 40, 30, p. 9032-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1302772
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Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol
Research output: Contribution to journal › Journal article › Research › peer-review
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275
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Origin and evolution of transporter substrate specificity within the NPF family: [with Correction]
Research output: Contribution to journal › Journal article › Research › peer-review
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243
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Activity of the Human Rhinovirus 3C Protease Studied in Various Buffers, Additives and Detergents Solutions for Recombinant Protein Production
Research output: Contribution to journal › Journal article › Research › peer-review
Published